HOME >> BIOLOGY >> NEWS
Molecule crucial for processing non-coding RNA identified

PHILADELPHIA The discovery in 1977 that the coding regions of a gene could appear in separate segments along the DNA won the 1993 Nobel Prize in Physiology or Medicine for Richard J. Roberts and Phillip A. Sharp. The active segments of a gene were termed exons, separated from each other within the gene by inactive introns.

The research suggested the necessary existence of a number of biological processes and active entities, many of which have since been tracked down by other scientists. Some, however, have resisted intensive inquiry. Now, researchers at The Wistar Institute and colleagues have resolved one of the important biological questions to which this earlier research pointed. A report on their findings appears in the October 21 issue of Cell.

Researchers who followed Roberts and Sharp discovered a molecular machine called a spliceosome, which was responsible for processing messenger RNA, or mRNA, the gene transcript from which proteins are produced. The spliceosome does this by snipping out the introns from the mRNA and then stitching together the exons into the finished mRNA. The activity takes place in the nucleus of the cell.

The spliceosome itself is composed of proteins and so-called small nuclear RNAs, or snRNAs. These snRNAs, as is the case with other forms of non-coding RNA in the nucleus, never produce proteins but play important roles in facilitating and regulating genetic activity. How these snRNAs were processed, however, remained a mystery for over twenty years. And because the spliceosome underlies the successful transcription of every single gene in the body, the question has been a vital one to answer.

In the new study, the Wistar-led research team identifies an entirely novel multi-protein complex called the Integrator that plays a central role in the processing of snRNAs. The Integrator appears to perform two important duties simultaneously. It binds a molecule called CTD, which is a component of the polym
'"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
20-Oct-2005


Page: 1 2

Related biology news :

1. Molecule blocks gene, sheds light on liver cancer
2. Molecule that destroys bone also protects it, new research shows
3. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award
4. Molecule discovered to be key to pain sensitivity
5. Molecules in blood foretell development of preeclampsia
6. Molecule by molecule, new assay shows real-time gene activity
7. Molecule does more than slice and dice RNA
8. Molecule links Down syndrome to Alzheimers
9. Molecule on immune cells linked to sexual transmission of HIV
10. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
11. Molecule that helps DNA replicate may make good target for cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/29/2018)... ... November 29, 2018 , ... ... to collaborate with the new NSF Engineering Research Center for Cell Manufacturing ... brought together to develop transformative tools and technologies for the consistent, scalable and ...
(Date:11/27/2018)... , ... November 27, 2018 , ... ... cryogenics industry a sealing solution with a broader range of usage temperature compared ... PEEK expert will introduce its new VICTREX CTâ„¢ 200 for dynamic sealing applications ...
(Date:11/20/2018)... , ... November 19, 2018 , ... ... Applications (academic research tools, drug development, agriculture, human clinical therapeutics, and animal and ... products), by Technology (drug compound and target screening, and agriculture and industrial use), ...
Breaking Biology News(10 mins):
(Date:11/20/2018)... ... 2018 , ... Each year Forbes receives thousands of nominations for candidates wishing ... by individuals under 30 years of age. The Forbes 30 Under 30 list showcases ... to Venture Capital and Science. , In 2017, Visikol CEO Dr. Michael Johnson ...
(Date:11/13/2018)... ... 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun offering ... Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a skilled surgeon ... to the island of Kauai on an almost weekly basis to perform surgery at ...
(Date:11/13/2018)... ... 2018 , ... Aditya Humad, Managing Partner of KICVentures ... it is still trending upward with growing valuations based on a largely under-served ... pricing pressure and increased competition as reasons often cited by institutional investors to ...
(Date:11/11/2018)... ... November 09, 2018 , ... Triple W, an innovator of connected health ... Honoree for DFree ®, the first health tech wearable device for incontinence ... go to the bathroom. The announcement was made during CES Unveiled New York, an ...
Breaking Biology Technology:
Cached News: