HOME >> BIOLOGY >> NEWS
Molecule links Down syndrome to Alzheimer's

Researchers from the Institute of Psychiatry at King's College London have identified a molecule that could be targeted to treat the cognitive impairment in people with Down syndrome. The study, published in Archives of General Psychiatry found that people with Down syndrome have higher levels of myo-inositol in their brains than people without the condition, and that increased levels of this molecule are associated with reduced intellectual ability.

The researchers also suspect that high levels of myo-inositol could play a role in predisposing people with Down syndrome to early-onset Alzheimer's disease. The molecule is known to promote the formation of amyloid plaques - a hallmark of Alzheimer's.

Once they reach 40 years old, almost all people with Down syndrome show the characteristic brain formations of Alzheimer's disease, though they don't all go on to get dementia. The combination of pre-existing mental retardation with an increasing overlying dementia is difficult to treat, and expensive to manage.

Professor Declan Murphy, who led the research said: 'We have shown in this study that adults with Down syndrome have a significantly higher concentration of myo-inositol in the hippocampal region of their brains, and this increase is associated with a reduced cognitive ability. We are now carrying out more studies to see if we can reduce the concentration of myo-inositol in the brains of people with Down's. We hope that if we can do this, it will be a new way of treating this disorder.'

Down syndrome is the most common genetic cause of mental retardation. It is caused when a child has three copies of chromosome 21, rather than the usual two.

One of the genes on chromosome 21 encodes a transporter that pumps the molecule myo-inositol into the brain. The increased levels of myo-inositol in the brains of people with Down syndrome could be explained by the fact that these people have an extra copy of the gene that makes this
'"/>

Contact: Gemma Bradley
pr@kcl.ac.uk
44-208-484-334
King's College London
5-Dec-2005


Page: 1 2

Related biology news :

1. Molecule blocks gene, sheds light on liver cancer
2. Molecule that destroys bone also protects it, new research shows
3. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award
4. Molecule discovered to be key to pain sensitivity
5. Molecules in blood foretell development of preeclampsia
6. Molecule by molecule, new assay shows real-time gene activity
7. Molecule does more than slice and dice RNA
8. Molecule crucial for processing non-coding RNA identified
9. Molecule on immune cells linked to sexual transmission of HIV
10. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
11. Molecule that helps DNA replicate may make good target for cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... ... December 04, 2018 , ... Slone Partners, North America’s leading ... Michael Mercer at Karius, Inc. as Chief Commercial Officer. Now responsible for developing, ... Karius' headquarters in Redwood City, California and report to CEO Mickey Kertesz Ph.D. ...
(Date:12/5/2018)... Texas (PRWEB) , ... December 04, 2018 , ... ... supplier, has announced the much-anticipated launch of their 100-liter (26 gallon) SAFEthread Drum. ... SAFEthread Drum in 2017, which brought a much-needed modern redesign to the ...
(Date:12/5/2018)... ... December 04, 2018 , ... ... expertise and existing IP in the development of innovative solutions for which high-speed ... into diverse systems from microfluidics to industrial machinery and instrumentation, allowing partner companies ...
Breaking Biology News(10 mins):
(Date:11/26/2018)... , ... November 26, 2018 , ... ... backed by Siemens Healthineers and Omphalos Venture Partners (Virtual Radiologic founders) among other ... Meeting from Nov. 25-29 at McCormick Place in Chicago. The company is proud ...
(Date:11/20/2018)... ... November 19, 2018 , ... Patients with missing teeth in Sandy ... from Dr. Dan Myers at THE DENTIST Centers without a referral. Dr. Myers ... for the last 20 years. He now offers skilled dental care in two practice ...
(Date:11/20/2018)... ... November 20, 2018 , ... Dr. Steven White and Dr. Brad Haines invite ... in Cornelius, NC. This common infection, left untreated, can be destructive to oral and ... training and certification in laser dentistry, Drs. White and Haines are uniquely qualified to ...
(Date:11/13/2018)... ... 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun offering ... Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a skilled surgeon ... to the island of Kauai on an almost weekly basis to perform surgery at ...
Breaking Biology Technology:
Cached News: