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Molecule that helps DNA replicate may make good target for cancer therapy

es the polymerase alpha complex. In cells lacking Mcm10, the catalytic subunit of the complex--the part that attaches to DNA--was degraded so it could not attach." If the complex cannot attach to DNA, cell division is stopped cold.

The proteins that bring about DNA replication have been highly conserved during evolution; that is, the proteins are virtually identical whether the organism is yeast, an invertebrate or a human. Therefore, whatever is learned from yeast--which are much easier to work with than are human cells--is likely applicable to humans, Bielinsky said. Among the next steps for her lab is to find exactly how Mcm10 interacts with the polymerase alpha complex, because disrupting this interaction in a cancer cell might prevent it from multiplying. Also, the researchers want to know what it is in the cell that causes the degradation of the polymerase alpha complex when no Mcm10 is around to protect it. Bielinsky and her group are now beginning to work with chicken blood cells to confirm that Mcm10 works the same way in vertebrates as in yeast.


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Contact: Deane Morrison
morri029@umn.edu
612-624-2346
University of Minnesota
21-Oct-2004


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