HOME >> BIOLOGY >> NEWS
Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

DALLAS March 15, 2005 A molecule that usually protects the body's infection-fighting cells might also contribute to fatty buildups that coat arteries and lead to heart disease, UT Southwestern Medical Center researchers have found.

The molecule, called apoptosis inhibitor of macrophage or AIM, inhibits cell death in macrophages, which circulate in the bloodstream and help the body fend off infection and foreign substances. The AIM-protected macrophages go on to encourage buildup of fats on the interior walls of arteries, according to Dr. Toru Miyazaki, senior author of a study that appears in the March issue of the journal Cell Metabolism.

"We found that AIM is highly expressed in certain macrophages and that lack of AIM dramatically decreased early atherosclerotic lesion development in mice," Dr. Miyazaki said. "These results may imply a novel therapeutic application of AIM regulation for prevention of atherosclerosis in the future. Most importantly and attractively for patients, this approach may not need dietary restriction."

Dr. Miyazaki, associate professor in the Center for Immunology and of pathology, and his colleagues first discovered the protective role of AIM six years ago. In the current study, scientists exposed mice lacking AIM to a fatty diet that would normally induce atherosclerosis.

After several weeks, researchers found little to no atherosclerotic lesions. Comparatively, in mice that had normal AIM function, there was marked presence of plaque deposits in the arteries following a diet of high-fat food.

"This was dramatic evidence that showed suppressing AIM function translates into prevention of atherosclerosis," Dr. Miyazaki said.

Atherosclerosis, known as "hardening of the arteries," occurs when the inside walls of an artery become thicker and less elastic.

This narrows the space for blood flow and can lead to angina and heart attacks in some people. Fatty buildups occur on the inner lining of an artery and gr
'"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Mar-2005


Page: 1 2

Related biology news :

1. Molecule blocks gene, sheds light on liver cancer
2. Molecule that destroys bone also protects it, new research shows
3. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award
4. Molecule discovered to be key to pain sensitivity
5. Molecules in blood foretell development of preeclampsia
6. Molecule by molecule, new assay shows real-time gene activity
7. Molecule does more than slice and dice RNA
8. Molecule links Down syndrome to Alzheimers
9. Molecule crucial for processing non-coding RNA identified
10. Molecule on immune cells linked to sexual transmission of HIV
11. Molecule that helps DNA replicate may make good target for cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/10/2018)... (PRWEB) , ... December 10, 2018 , ... ... a strategic alliance to advance their shared goal of accelerating the development of ... unique scale-up bioprocess systems to TRT’s core technology around human umbilical cord perivascular ...
(Date:12/5/2018)... ... December 03, 2018 , ... uBiome, the leader ... professor in the Division of Gastroenterology and Hepatology at UC San Diego and ... Board. Joining the board of leading scientists and doctors from around the world, ...
(Date:12/5/2018)... ... December 04, 2018 , ... ... the much-anticipated launch of their 100-liter (26 gallon) SAFEthread Drum. The 100-liter ... in 2017, which brought a much-needed modern redesign to the plastic drums being ...
Breaking Biology News(10 mins):
(Date:11/20/2018)... SPRINGS, Ga. (PRWEB) , ... November 19, 2018 , ... ... now receive custom dental implants from Dr. Dan Myers at THE DENTIST ... offering dental implant placement and restorations for the last 20 years. He now offers ...
(Date:11/20/2018)... , ... November 20, 2018 , ... Dr. Steven White ... for gingivitis at their office in Cornelius, NC. This common infection, left untreated, can ... in practice, along with special training and certification in laser dentistry, Drs. White and ...
(Date:11/13/2018)... ... November 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has ... Kauai. Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a ... began traveling to the island of Kauai on an almost weekly basis to perform ...
(Date:11/13/2018)... Sandy Springs, GA (PRWEB) , ... November 12, ... ... cosmetic dentist with state-of-the-art practices in Alpharetta and Sandy Springs, now welcomes ... clear aligners provide a discreet and comfortable alternative to traditional braces in the ...
Breaking Biology Technology:
Cached News: