HOME >> BIOLOGY >> NEWS
Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

DALLAS March 15, 2005 A molecule that usually protects the body's infection-fighting cells might also contribute to fatty buildups that coat arteries and lead to heart disease, UT Southwestern Medical Center researchers have found.

The molecule, called apoptosis inhibitor of macrophage or AIM, inhibits cell death in macrophages, which circulate in the bloodstream and help the body fend off infection and foreign substances. The AIM-protected macrophages go on to encourage buildup of fats on the interior walls of arteries, according to Dr. Toru Miyazaki, senior author of a study that appears in the March issue of the journal Cell Metabolism.

"We found that AIM is highly expressed in certain macrophages and that lack of AIM dramatically decreased early atherosclerotic lesion development in mice," Dr. Miyazaki said. "These results may imply a novel therapeutic application of AIM regulation for prevention of atherosclerosis in the future. Most importantly and attractively for patients, this approach may not need dietary restriction."

Dr. Miyazaki, associate professor in the Center for Immunology and of pathology, and his colleagues first discovered the protective role of AIM six years ago. In the current study, scientists exposed mice lacking AIM to a fatty diet that would normally induce atherosclerosis.

After several weeks, researchers found little to no atherosclerotic lesions. Comparatively, in mice that had normal AIM function, there was marked presence of plaque deposits in the arteries following a diet of high-fat food.

"This was dramatic evidence that showed suppressing AIM function translates into prevention of atherosclerosis," Dr. Miyazaki said.

Atherosclerosis, known as "hardening of the arteries," occurs when the inside walls of an artery become thicker and less elastic.

This narrows the space for blood flow and can lead to angina and heart attacks in some people. Fatty buildups occur on the inner lining of an artery and gr
'"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Mar-2005


Page: 1 2

Related biology news :

1. Molecule blocks gene, sheds light on liver cancer
2. Molecule that destroys bone also protects it, new research shows
3. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award
4. Molecule discovered to be key to pain sensitivity
5. Molecules in blood foretell development of preeclampsia
6. Molecule by molecule, new assay shows real-time gene activity
7. Molecule does more than slice and dice RNA
8. Molecule links Down syndrome to Alzheimers
9. Molecule crucial for processing non-coding RNA identified
10. Molecule on immune cells linked to sexual transmission of HIV
11. Molecule that helps DNA replicate may make good target for cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/14/2018)... ... December 14, 2018 , ... uBiome, the leader in ... for Microbiome-Derived Diagnostics and Therapeutics” by the US Patent and Trademark Office on ... is an invention by uBiome collaborators Dr. Zachary Apte, Dr. Daniel Almonacid, Dr. ...
(Date:12/13/2018)... ... 2018 , ... Illumina, Kaiser Permanente, ResMed and Aetna were just a few ... and cooking events company has hosted an impressive guest list of Fortune 500 businesses, ... Each group who visits receives a completely customized experience, right down to the menu ...
(Date:12/10/2018)... , ... December 10, 2018 , ... ... strategic alliance to advance their shared goal of accelerating the development of the ... scale-up bioprocess systems to TRT’s core technology around human umbilical cord perivascular cells ...
Breaking Biology News(10 mins):
(Date:1/10/2019)... ... January 08, 2019 , ... ... announced today that SAGICO will be represented at the 37th Annual J.P. ... Healthcare Conference is the largest and most informative healthcare investment symposium in ...
(Date:1/8/2019)... ... January 07, 2019 , ... ... members into Noninvasix. This represents the second investment AngelMD has made into Noninvasix ... morbidity, Noninvasix is developing a patient monitor to directly, accurately, and noninvasively measure ...
(Date:1/7/2019)... ... January 07, 2019 , ... Kainos Medicine Inc. today ... drug candidate, code-named "KM-819." KM-819 is an orally active small molecule that ... South Korea. , This Phase 1 randomized, double-blind, placebo-controlled dose-escalation study was ...
(Date:1/4/2019)... ... January 01, 2019 , ... uBiome, the ... World Economic Forum Annual Meeting January 22-25, 2019 held in Davos-Klosters, Switzerland following ... World Economic Forum Annual Meeting brings together leaders of global society–the heads and ...
Breaking Biology Technology:
Cached News: