HOME >> BIOLOGY >> NEWS
Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

adually thicken into a plaque. As plaque grows, it narrows the artery more and more. When the plaque ruptures, blood clots form that can block the artery entirely.

Low-density lipoprotein is transported inside arteries by macrophages, which engulf the cholesterol through a process called oxidation. Macrophages produce pro-inflammatory substances, which cause a secondary effect, encouraging other cells to accumulate and worsen plaque buildup in arteries.

"The oxidized lipids are cleared out by macrophage cells, but the lipids themselves are very toxic to cells and promote apoptosis (cell death)," Dr. Miyazaki said. "Therefore AIM production is a self-defense mechanism for macrophage cells, but interestingly, is in turn detrimental for the body."

Atherosclerosis is a contributing factor to a number of cardiovascular diseases the No. 1 cause of death among people in the United States. It is also highly associated with other risk factors such as smoking, obesity and diets high in fat and cholesterol.


'"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Mar-2005


Page: 1 2

Related biology news :

1. Molecule blocks gene, sheds light on liver cancer
2. Molecule that destroys bone also protects it, new research shows
3. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award
4. Molecule discovered to be key to pain sensitivity
5. Molecules in blood foretell development of preeclampsia
6. Molecule by molecule, new assay shows real-time gene activity
7. Molecule does more than slice and dice RNA
8. Molecule links Down syndrome to Alzheimers
9. Molecule crucial for processing non-coding RNA identified
10. Molecule on immune cells linked to sexual transmission of HIV
11. Molecule that helps DNA replicate may make good target for cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... ... January 31, 2019 , ... ... NC, providing full, customizable clinical research services across multiple therapeutic areas, announced ... for early stage life science entrepreneurs in the Research Triangle region of ...
(Date:1/25/2019)... ... January 24, 2019 , ... GrowthZone, Inc., ... Survey. The report indicates membership growth in some sectors and decreasing membership among ... received responses from over 500 association professionals across North America. , “This ...
(Date:1/20/2019)... , ... January 16, 2019 , ... As the leader ... through the introduction of its own liver 3D cell culture models. In an effort ... models, protocols and validation criteria so that any researcher can replicate these models for ...
Breaking Biology News(10 mins):
(Date:2/6/2019)... ... February 05, 2019 , ... Firmex announced today that ... to acquire Firmex, one of the fastest-growing and most widely-used providers of virtual ... firm. Debt financing was provided by the Bank of Montreal. , Headquartered in ...
(Date:2/2/2019)... ... January 31, 2019 , ... Dust off your Doc Martens, Virun ... the Nuriv 2019 Expo West Music and Tech Festival at the ESports Arena in ... in the natural foods, beverages, and dietary supplement industries, the Nuriv Music and Tech ...
(Date:2/2/2019)... ... February 01, 2019 , ... Biomatlante, a world ... its new CEO, Julien Dert, being effective on February 1st, 2019. , Graduated ... and management, in which more than 12 years in the Medical Device industry. ...
(Date:1/30/2019)... ... January 29, 2019 , ... ... Manufacturing Organization (CDMO) serving the global biopharmaceutical and biotechnology industries with sites in ... million backed by multiple global investors lead by China's State Development & Investment ...
Breaking Biology Technology:
Cached News: