HOME >> BIOLOGY >> NEWS
Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

adually thicken into a plaque. As plaque grows, it narrows the artery more and more. When the plaque ruptures, blood clots form that can block the artery entirely.

Low-density lipoprotein is transported inside arteries by macrophages, which engulf the cholesterol through a process called oxidation. Macrophages produce pro-inflammatory substances, which cause a secondary effect, encouraging other cells to accumulate and worsen plaque buildup in arteries.

"The oxidized lipids are cleared out by macrophage cells, but the lipids themselves are very toxic to cells and promote apoptosis (cell death)," Dr. Miyazaki said. "Therefore AIM production is a self-defense mechanism for macrophage cells, but interestingly, is in turn detrimental for the body."

Atherosclerosis is a contributing factor to a number of cardiovascular diseases the No. 1 cause of death among people in the United States. It is also highly associated with other risk factors such as smoking, obesity and diets high in fat and cholesterol.


'"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Mar-2005


Page: 1 2

Related biology news :

1. Molecule blocks gene, sheds light on liver cancer
2. Molecule that destroys bone also protects it, new research shows
3. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award
4. Molecule discovered to be key to pain sensitivity
5. Molecules in blood foretell development of preeclampsia
6. Molecule by molecule, new assay shows real-time gene activity
7. Molecule does more than slice and dice RNA
8. Molecule links Down syndrome to Alzheimers
9. Molecule crucial for processing non-coding RNA identified
10. Molecule on immune cells linked to sexual transmission of HIV
11. Molecule that helps DNA replicate may make good target for cancer therapy

Post Your Comments:
(Date:8/19/2014)... rating systems be used in supermarkets to encourage healthier ... sought to answer that very question by tracking the ... Guiding Stars System to rate the nutritional value of ... and Brand Lab,s David Just, PhD, and Brian Wansink ... sales records of over 150 Hannaford Supermarkets in the ...
(Date:8/19/2014)... this week,s Eos: Long-Term Ecological Research and Network-Level Science, ... how a wide range of ecosystems was responding to ... be particularly powerful if it coupled multiple decades of ... long-term experiments and models from dozens of different ecosystem ... is the Long-Term Ecological Research (LTER) Network, which will ...
(Date:8/19/2014)... many parts of the world, leprosy and tuberculosis ... cases of leprosy per year, with nearly all ... currently available century-old vaccine Bacille Calmette-Guerin, or BCG, ... leprosy, so a more potent vaccine is needed ... found a stronger weapon against both diseases., In ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2
(Date:8/20/2014)... measuring vibrational motion of a single molecule with a ... a single molecule differs from the behaviour of larger ... the University of California, Irvine, where post-doctoral researcher Eero ... visiting fellow under professor Vartkess A. Apkarian, whose team ... by Professor Eric O. Potma. The results of the ...
(Date:8/20/2014)... -- PAREXEL International Corporation (NASDAQ: PRXL ) announced ... Healthcare Conference in New York.  Ingo Bank , ... making a presentation on PAREXEL and discussing business developments ... A live webcast of the discussion will ... at www.PAREXEL.com in the Upcoming Events portion ...
(Date:8/20/2014)... nerves in your ear could improve the health of ... the University of Leeds used a standard TENS machine ... electrical pulses to the tragus, the small raised flap ... of the ear canal. , The stimulation changed the ... reducing the nervous signals that can drive failing hearts ...
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced ... Nexera-i, adding to the company’s extensive line-up of ... intuitive operating environment, and full automation, the i-Series ... for conventional to ultra-high-speed analysis. , ... design so users can begin building the lab ...
Breaking Biology Technology:Seeing a molecule breathe 2PAREXEL International To Present At Baird Healthcare Conference 2'Tickling' your ear could be good for your heart 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
Cached News: