adually thicken into a plaque. As plaque grows, it narrows the artery more and more. When the plaque ruptures, blood clots form that can block the artery entirely.
Low-density lipoprotein is transported inside arteries by macrophages, which engulf the cholesterol through a process called oxidation. Macrophages produce pro-inflammatory substances, which cause a secondary effect, encouraging other cells to accumulate and worsen plaque buildup in arteries.
"The oxidized lipids are cleared out by macrophage cells, but the lipids themselves are very toxic to cells and promote apoptosis (cell death)," Dr. Miyazaki said. "Therefore AIM production is a self-defense mechanism for macrophage cells, but interestingly, is in turn detrimental for the body."
Atherosclerosis is a contributing factor to a number of cardiovascular diseases the No. 1 cause of death among people in the United States. It is also highly associated with other risk factors such as smoking, obesity and diets high in fat and cholesterol.
Page: 1 2 Related biology news :1
Contact: Katherine Morales
UT Southwestern Medical Center
. Molecule blocks gene, sheds light on liver cancer2
. Molecule that destroys bone also protects it, new research shows3
. Howard C. Berg honored with Outstanding Investigator in Single Molecule Biology Award4
. Molecule discovered to be key to pain sensitivity5
. Molecules in blood foretell development of preeclampsia6
. Molecule by molecule, new assay shows real-time gene activity7
. Molecule does more than slice and dice RNA8
. Molecule links Down syndrome to Alzheimers9
. Molecule crucial for processing non-coding RNA identified10
. Molecule on immune cells linked to sexual transmission of HIV11
. Molecule that helps DNA replicate may make good target for cancer therapy