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Mosquito immune system examined

ria in humans and another that only infects rodents. The study revealed that mosquitoes mostly employ the same immune factors in defending against the two different Plasmodium species. Only a few immune genes were more important in the defense against either one of the two species.

"The mosquito's immune system appears to employ a variety of antimicrobial defense factors (genes) against the malaria parasite, and can therefore significantly limit infection. The parasite, on the other hand, is capable of evading these defenses to a degree that allows its transmission by the mosquito. Now we have to figure out how to make the mosquito's immune system more effective in killing malaria parasites at multiple stages that would render the development of evasive mechanisms impossible for the parasite," said Dimopoulos.


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Contact: Tim Parsons
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
8-Jun-2006


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