HOME >> BIOLOGY >> NEWS
Most common lung cancers may begin in newly discovered cells

The most common form of lung cancer may begin in a group of newly isolated lung stem cells, according to researchers from the Howard Hughes Medical Institute.

Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung. Their experiments show that at the earliest stage of tumor development, the stem cell appears to be the first lung cells that respond to a cancer-causing mutation. The newly identified cell type fulfills all but one of the strictest criteria that scientists look for in defining adult stem cells.

The study is published in the June 17, 2005, issue of the journal Cell.

"The work of Bender Kim and colleagues represents not only a leap forward in our understanding of lung tumorigenesis, it also heralds the arrival of a valuable mouse model for identifying those cells that should be the targets of therapeutic intervention," wrote Anton Berns of The Netherlands Cancer Center in Amsterdam in an accompanying commentary in Cell.

The identification of the cells could lead to earlier diagnosis of lung cancer in people. Lung cancer is the leading cause of cancer-related death in the United States, in part because it is usually detected at an advanced stage. Patients in whom the disease has spread to other organs have a five-year survival rate of only two percent. In contrast, lung cancer detected at an early stage boasts a 50 percent survival rate over a five-year period.

"There are many similarities between stem cells and cancer," said first author Carla Bender Kim, a postdoctoral fellow in the lab of senior author Tyler Jacks, a Howard Hughes Medical Institute investigator at Massachusetts Institute of Technology. "Cancer cells can continue to divide many times. Likewise, stem cells can divide over the lifespan of the organism. Also, tumors are very heterogeneous, composed of many different cells,
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
16-Jun-2005


Page: 1 2 3 4

Related biology news :

1. Features of replication suggest viruses have common themes, vulnerabilities
2. Risk of common vaginal infection linked to preterm birth appears higher for blacks
3. New gene mutation identified in common type of dementia
4. Study identifies a common genetic risk factor for colorectal and prostate cancer
5. Researchers pit novel version of common virus against cancer
6. Gene responsible for common hearing loss identified for first time
7. OSA symptoms more common among African-American women than Caucasians
8. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
9. Largest ever study of genetics of common diseases published today
10. First confirmed common genetic risk factors for breast cancer
11. Scripps research study shows humans and plants share common regulatory pathway

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/13/2017)... 2017 According to a new market research report ... Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region ... expected to grow from USD 14.30 Billion in 2017 to USD 31.75 ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... N.J. (PRWEB) , ... July 17, 2017 , ... ... laboratory equipment and analytical instruments announced the launch of its new line of ... heavy-duty orbital shaker models (both analog and digital) for laboratory applications. These ...
(Date:7/17/2017)... ... , ... Panitch Schwarze Belisario & Nadel intellectual ... Innovation Group) annual meeting in China. , This year’s meeting, held June 9-10 ... a rapidly developing highly personalized anti-cancer technology that involves removing some of a ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... innovation strategy. A website (openinnovation.pioneer.com) dedicated to connecting third-party innovators with ... trait discovery, plant breeding, enabling technologies, biologicals and digital solutions. , “DuPont Pioneer ...
(Date:7/16/2017)... (PRWEB) , ... July 16, 2017 , ... ... equipment and analytical instruments announced the launch of its new line of Extreme ... ideal for applications that require CO2 and humidity for optimal cell growth such ...
Breaking Biology Technology:
Cached News: