Mouse, frog and bird put Snail and Slug to different uses

Bar Harbor, Maine--With names like Snail and Slug, you might expect genes belonging to the category known as the Snail family to be associated with some steady, slow-moving biological progression. Instead, these genes help direct the dynamic, fast-paced race of early embryonic development, when cells are dividing, migrating around the body and differentiating into the millions, even trillions, of specialized cells that constitute a mature organism.

Snail family genes are present in vertebrates and have counterparts in invertebrates such as the fruit fly Drosophila. To biologists, this means that these genes are "well conserved across species"--in other words, diverse species retained them as they evolved. So it's reasonable to expect that their function would be the same among all vertebrates: mice as well as frogs and birds, for instance.

In a paper just released in the Proceedings of the National Academy of Sciences, two Jackson Laboratory scientists have demonstrated both a confirmation of the consistent role of Snail genes in vertebrates, and a surprising exception.

Dr. Thomas Gridley and Dr. Steven Murray showed that Snail family genes operate consistently in mice and birds in controlling the acquisition of differences between the two sides of the body. While the body plan of all vertebrates is overtly symmetric on both body sides, most internal organs exhibit an asymmetric distribution. For example, in mammals the heart is located on the left side of the body while the liver is on the right. Gridley and Murray found that, similarly to what has been described for birds, the Snail gene controls acquisition of these asymmetric body differences in mice.

On the other hand, Gridley and Murray found that Snail family gene function relating to neural crest cells is different in mice. Neural crest cells are developmental cells that form at the border of the embryonic neural plate (a structure that later develops into the spina

Contact: Mark Wanner
Jackson Laboratory

Page: 1 2

Related biology news :

1. Research: Snails were overlooked contributors to marsh destruction
2. A sensory organ, not the brain, differentiates male and female behavior in some mammals
3. New clue why MS affects African-Americans differently than Caucasians
4. Marine phytoplankton changes form to protect itself from different predators
5. Mice, men make livers differently
6. Palaus coral reefs show differential habitat recovery following the 1998 bleaching event
7. Hearts of male and female rainbow trout are different
8. Freeze! Scientists film proteins at work by freezing them at different states
9. NYU scientists identify how development of different species uses same genes with distinct features
10. Making daughters different -- how immune cells take divergent paths when fighting infections
11. UT-Houston scientists develop new procedure to differentiate human embryonic stem cells

Post Your Comments:

(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... SARASOTA, FL (PRWEB) , ... ... ... Inc. (RPS®) today announces publication of a United States multicenter, prospective clinical ... single use, disposable, point-of-care diagnostic test capable of identifying clinically significant acute ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... (PRWEB) , ... October 10, ... ... development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed ... targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with ...
Breaking Biology Technology:
Cached News: