HOME >> BIOLOGY >> NEWS
Mouse model advances understanding of synovial sarcoma

A mouse model for synovial sarcoma has enabled scientists to make tremendous progress toward understanding the origin and pathogenesis of this highly aggressive soft-tissue malignancy. The research, published in the April issue of the journal Cancer Cell, published by Cell Press, provides new information about the timing and environment required for initiation and progression of synovial sarcoma. The mouse model is also likely to serve as an invaluable resource for development of successful therapeutic strategies for this often lethal cancer.

Synovial sarcoma is associated with expression of a chimeric fusion protein called SYT-SSX. Dr. Mario R. Capecchi, from the Howard Hughes Medical Institute and the Department of Human Genetics at the University of Utah School of Medicine, and colleagues developed a mouse model that expresses human SYT-SSX in chosen target cells. Using this approach, the researchers discovered that, although it is named for its common proximity to limb joints, this tumor appears to arise from skeletal muscle precursor cells called myoblasts. Remarkably, expression of SYT-SSX in myoblasts was sufficient to induce synovial sarcoma with an astonishing 100% penetrance.

Use of a sophisticated conditional genetic technique allowed the researchers to control the timing of fusion protein expression so as to examine what happens when the protein is expressed at different stages of muscle development. Earlier expression of SYT-SSX disrupted normal development and was associated with embryonic lethality, while expression in more differentiated muscle cells induced significant muscle cell damage and death in the absence of tumor formation.

Further studies demonstrated that this mouse model of synovial sarcoma faithfully recapitulates human synovial sarcoma on multiple levels. As in the human cancer, tumors in the mice arise most commonly in close proximity to joints. The researchers speculate that the cartilage associa
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
9-Apr-2007


Page: 1 2

Related biology news :

1. Mouse FH knockout resembles human renal cell cancer
2. Mouse stem cell line advance suggests potential for IVF-incompetent eggs
3. Mouse model underestimates the critical role of Tyk2 in human immune system
4. Mouse DNA to aid biomedical research
5. Mouse strain with gene stutter will help leukemia research
6. Knockout Mouse Project
7. NIH launches Knockout Mouse Project
8. Mouse mimics chronic leukemia, will aid drug development
9. Mouse, frog and bird put Snail and Slug to different uses
10. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
11. Mouse to man: The story of chromosomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/14/2019)... ... January 14, 2019 , ... Join ... (4pm GMT) to hear about key topics in data quality, including:, ... ,     Patient engagement ,     Smartphone and wearable based performance measures , ...
(Date:1/10/2019)... ... January 10, 2019 , ... When Dr. James L. ... , was invited to contribute a chapter to the new book Perinatal Stem Cells: ... continue Asymmetrex’s effort to address a debilitating secret of stem cell medicine. For ...
(Date:1/8/2019)... ... ... Join industry experts Julie Peacock, Client Services at Comprehend and Heather Davis, Independent Consultant ... at 1pm EST. , This webinar will dive into best practices for the ... also present a case study of a leading pharmaceutical company that faced multiple challenges ...
Breaking Biology News(10 mins):
(Date:1/8/2019)... ... January 07, 2019 , ... Today ... Noninvasix. This represents the second investment AngelMD has made into Noninvasix in the ... is developing a patient monitor to directly, accurately, and noninvasively measure brain oxygenation ...
(Date:1/4/2019)... FRANCISCO (PRWEB) , ... January 01, 2019 , ... ... world’s first Microbiome Conference at the World Economic Forum Annual Meeting January 22-25, ... The conference is invitation-only. , The World Economic Forum Annual Meeting brings together ...
(Date:12/19/2018)... (PRWEB) , ... December 19, 2018 , ... ... procedures at its first rate Stem Cell Training Course in Las Vegas. Training ... women. As regenerative procedures explode in popularity nationwide for aesthetics, having the training ...
(Date:12/18/2018)... ... December 18, 2018 , ... Patients with early stages of breast ... of life post-treatment versus whole breast irradiation, a new study suggests. , Patients with ... whole breast irradiation after removal of the cancerous tumor because there is a 30 ...
Breaking Biology Technology:
Cached News: