HOME >> BIOLOGY >> NEWS
Mouse model advances understanding of synovial sarcoma

A mouse model for synovial sarcoma has enabled scientists to make tremendous progress toward understanding the origin and pathogenesis of this highly aggressive soft-tissue malignancy. The research, published in the April issue of the journal Cancer Cell, published by Cell Press, provides new information about the timing and environment required for initiation and progression of synovial sarcoma. The mouse model is also likely to serve as an invaluable resource for development of successful therapeutic strategies for this often lethal cancer.

Synovial sarcoma is associated with expression of a chimeric fusion protein called SYT-SSX. Dr. Mario R. Capecchi, from the Howard Hughes Medical Institute and the Department of Human Genetics at the University of Utah School of Medicine, and colleagues developed a mouse model that expresses human SYT-SSX in chosen target cells. Using this approach, the researchers discovered that, although it is named for its common proximity to limb joints, this tumor appears to arise from skeletal muscle precursor cells called myoblasts. Remarkably, expression of SYT-SSX in myoblasts was sufficient to induce synovial sarcoma with an astonishing 100% penetrance.

Use of a sophisticated conditional genetic technique allowed the researchers to control the timing of fusion protein expression so as to examine what happens when the protein is expressed at different stages of muscle development. Earlier expression of SYT-SSX disrupted normal development and was associated with embryonic lethality, while expression in more differentiated muscle cells induced significant muscle cell damage and death in the absence of tumor formation.

Further studies demonstrated that this mouse model of synovial sarcoma faithfully recapitulates human synovial sarcoma on multiple levels. As in the human cancer, tumors in the mice arise most commonly in close proximity to joints. The researchers speculate that the cartilage associa
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
9-Apr-2007


Page: 1 2

Related biology news :

1. Mouse FH knockout resembles human renal cell cancer
2. Mouse stem cell line advance suggests potential for IVF-incompetent eggs
3. Mouse model underestimates the critical role of Tyk2 in human immune system
4. Mouse DNA to aid biomedical research
5. Mouse strain with gene stutter will help leukemia research
6. Knockout Mouse Project
7. NIH launches Knockout Mouse Project
8. Mouse mimics chronic leukemia, will aid drug development
9. Mouse, frog and bird put Snail and Slug to different uses
10. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
11. Mouse to man: The story of chromosomes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse model advances understanding synovial sarcoma

(Date:8/22/2014)... Calif. Thomson Reuters , a leading source ... researchers at the University of California, Riverside in its ... minds of our times." , To generate the list, ... to identify researchers whose published work has had enormous ... among some 3,200 individuals who published the greatest number ...
(Date:8/22/2014)... Jolla, CA Research presented at the 29th ... being developed by Hera Therapeutics Inc. combats three ... cause 70 percent of all cervical cancer. , ... HTI-1968 blocked the replication of HPV-16, HPV-18 and ... and Thomas Broker, Ph.D., who presented the findings ...
(Date:8/22/2014)... news release is available in French . ... drain of essential nutrients from African soils looming as a ... report released today finds that over the last five years, ... practices that have rejuvenated 1.6 million hectares and helped them ... the Alliance for a Green Revolution in Africa (AGRA) focuses ...
Breaking Biology News(10 mins):5 UC Riverside scientists among world's most influential scientific minds 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4
(Date:8/21/2014)... , Aug. 21, 2014 Telomere ... of their Nutraceutical "TELO-20 for Dogs" with ... Telomere-lengthening supplement in the world for dogs. Telomeres ... every chromosome in the body. A wealth of ... experts in Telomere Science and Aging, including Nobel ...
(Date:8/21/2014)... 2014  Decision Resources Group finds that the ... and Mexico currently faces ... approved agents, the anticipated label extension of Boehringer ... of emerging biologics will substantially increase the competitiveness ... IL-5 inhibitors will introduce a new dynamic to the ...
(Date:8/21/2014)... YORK , Aug. 21, 2014 ... congratulates Immune Pharmaceuticals Inc., a biotechnology company, on ... Market.  Immune previously traded on OTCQX®, the best ... by OTC Markets Group. Logo - ... Pharmaceuticals on the successful execution of its growth ...
(Date:8/21/2014)... MOUNTAIN VIEW, Calif. , Aug. 21, 2014 ... their properties and behaviors based on external stimuli ... is poised to have a disruptive effect in ... will revolutionize the business landscape by printing objects ... the aerospace and automotive sectors. Logo ...
Breaking Biology Technology:Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4
Cached News: