HOME >> BIOLOGY >> NEWS
Mouse strain with gene stutter will help leukemia research

COLUMBUS, Ohio Cancer researchers have developed a new strain of mice that should help reveal how an unusual change in a certain gene contributes to a particularly deadly form of acute myeloid leukemia (AML).

A study of the strain by its developers at the Ohio State University Comprehensive Cancer Center (OSUCCC) suggests that the genetic change comes early in the disease, and that it over-activates a second gene that helps govern blood cell development.

The genetic change, known as a partial tandem duplication, is located in a gene called MLL (for mixed-lineage leukemia). A partial tandem duplication is a type of gene mutation that occurs when a section of a gene is repeated, like a stutter in the gene's DNA.

The new mouse model should help leukemia researchers to learn how this mutation contributes to AML development, and it may lead to new ways to treat, diagnose and perhaps prevent the disease.

The findings were published online Sept. 14 in the Journal of Clinical Investigation.

"When leukemia strikes, it's like a hurricane arriving without an advance weather forecast you have no information about how it got there, and it's a level-5 storm," says Michael A. Caligiuri, principal investigator of the study and director of the OSUCCC.

"Studying live models like this mouse strain helps us begin to understand the earliest events in the development of leukemia. This in turn will someday allow us to understand what causes leukemia in people, predict who is at greatest risk and prevent leukemia from ever developing in those patients."

Genes store information for a protein. Mutations can alter the protein, perhaps making it function differently. In this case, the duplication within the MLL gene contributes to an aggressive form of AML. This new study begins to reveal how it does so.

AML will strike an estimated 10,000 Americans this year, and about 45 percent of those will have cancer cel
'"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University
19-Sep-2006


Page: 1 2 3

Related biology news :

1. Mouse model advances understanding of synovial sarcoma
2. Mouse FH knockout resembles human renal cell cancer
3. Mouse stem cell line advance suggests potential for IVF-incompetent eggs
4. Mouse model underestimates the critical role of Tyk2 in human immune system
5. Mouse DNA to aid biomedical research
6. Knockout Mouse Project
7. NIH launches Knockout Mouse Project
8. Mouse mimics chronic leukemia, will aid drug development
9. Mouse, frog and bird put Snail and Slug to different uses
10. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
11. Mouse to man: The story of chromosomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2019)... SASKATOON, Canada (PRWEB) , ... February 12, 2019 ... ... immediately it will begin operating under its new name, KEYLEAF. The company ... more of its own plant-based extracts and ingredients as finished products under the ...
(Date:2/2/2019)... ... January 31, 2019 , ... ... geared toward clinical operations executives and focusing on all facets of clinical trial ... project management, portfolio management, resource management, patient engagement, and more. , “We ...
(Date:1/25/2019)... ... January 24, 2019 , ... ... PhD, Assistant Professor of Microbiology at the Jackson Laboratory (JAX), to its Scientific ... world, Dr. Oh will bring to uBiome expertise in skin microbial interactions and ...
Breaking Biology News(10 mins):
(Date:2/12/2019)... ... February 12, 2019 , ... ... has finalized a deal to extend their use of Medrio, the leading provider ... 2023. The CRO has been a regular Medrio customer for over nine years, ...
(Date:2/2/2019)... ... , ... Signature Matrix and Signature Cord are the culmination ... cell research expert and Amazon best-selling author, Neil Riordan, PA, PhD, and his ... allograft that originates from the same tissue used to manufacture the purified, expanded ...
(Date:1/30/2019)... ... January 29, 2019 , ... ... Lifecycle since 2016. In his position as Director of Sales and Marketing, Mr. ... services supplier across multiple industries the company supports. During this time, Mr. Schieving ...
(Date:1/30/2019)... ... January 30, 2019 , ... The Society for Laboratory ... to discuss best practices for laboratory automation and screening. This year the conference ... year’s conference, Visikol will be at booth #345 and throughout the conference will ...
Breaking Biology Technology:
Cached News: