HOME >> BIOLOGY >> NEWS
Movie spies on malaria parasite's sneaky behavior

Malaria has been outsmarting the human immune system for centuries. Now, using real-time imaging to track malaria infections in live mice, researchers have discovered one of the parasite's sneakiest tricks--using dead liver cells to cloak and transport itself back into the bloodstream after leaving the liver.

Robert Mnard, a Howard Hughes Medical Institute (HHMI) international research scholar, and his postdoctoral fellow, Rogerio Amino, at the Institut Pasteur in Paris, filmed the malaria parasite as it transitioned from infecting liver cells to infecting red blood cells. During this stage of the parasite's life cycle, the classic symptoms of malaria high fevers and chills are triggered in people who are infected.

Mnard and Amino collaborated with Volker Heussler at the Bernhard-Nocht Institute for Tropical Medicine in Hamburg, Germany. Their images of the parasite sneaking back into the host's bloodstream--published in advance online in Science Express on August 3, 2006, and scheduled for September 2006 publication in Science--clear up a long-standing puzzle about the malaria parasite's life cycle. The discovery could lead to new ways of treating malaria, a disease that infects 300 million people per year and kills 1 million.

"The parasite has evolved this complex structure. The best image to describe it is the Trojan horse, because it both transports the parasites and camouflages them," said Mnard. Like the ancient Greek warriors who hid inside a giant hollow horse to gain entry to Troy, the malaria parasites wrap themselves in a structure made of liver cell membrane. This membrane cloak enables them to sneak past immune cell sentinels and return to the bloodstream.

The malaria parasite, Plasmodium falciparum, has a complex life cycle. It passes from a mosquito's saliva to a human's blood, and then travels to the liver, where it infects and kills liver cells. After it leaves the liver, the parasite moves back into the
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
4-Aug-2006


Page: 1 2 3

Related biology news :

1. Movies reveal that the process of insulating nerves is surprisingly dynamic
2. Molecular spies illuminate drug resistance proteins
3. Edible fish feasts beats malaria
4. Identified mechanism in the malaria parasite to help it adapt to infected individuals
5. CRESIB coordinates an international consortium to fight malaria caused by Plasmodium vivax
6. Key to tackling malaria may lie in bed nets for adults and older children
7. Largest synthetic gene ever built offers insights into anti-malarial drug resistance
8. MIT-led team uncovers malaria mechanism
9. Vaccine hope for malaria
10. Antibody-based therapies effective at controlling malaria
11. Researchers identify key protein in immune response to malaria and TB

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Movie spies malaria parasite sneaky behavior

(Date:8/21/2014)... In a finding that has implications for life ... elsewhere in the solar system, LSU Associate Professor of ... the National Science Foundation, or NSF, this week published ... a lake that lies 800 meters (2600 feet) beneath ... "viable microbial ecosystems.", Given that more than 400 subglacial ...
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/20/2014)... 2014 George E. Fox, a John and Rebecca Moores ... (UH), was named a fellow in the International Society for ... Fox is one of four members two from the ... as fellows in 2014. Fellows are elected every three years, ... 500 members from more than 20 countries, the ISSOL includes ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4New feeding tube connectors will improve patient safety 2UH professor named fellow by International Astrobiology Society 2
(Date:8/21/2014)... IA (PRWEB) August 21, 2014 His ... LIBERTY Opening , The Court of His Majesty Willem-Alexander, ... will attend the Grand Opening of POET-DSM Advanced Biofuels’ ... Wednesday, Sept. 3. , The King will take part ... opening activity, scheduled for 11 a.m.-12:20 p.m. and tour ...
(Date:8/21/2014)... Mass. , Aug. 21, 2014  Decision ... Brazil and ... The uptake of several newly approved agents, the ... this indication and the launch of emerging biologics ... markets. In particular, the emerging IL-5 inhibitors will ...
(Date:8/21/2014)... Aug. 21, 2014  China Cord Blood Corporation (NYSE: ... to release financial results for the first quarter of ... market close in the US.  The ... ET on Friday, August 29, 2014 to discuss its ... Company,s recent developments, followed by a question and answer ...
(Date:8/21/2014)... Sofia, Bulgaria (PRWEB) August 21, 2014 ... was released today by Ontotext . Now ... and semantic analysis of structured and unstructured data is ... of the cost of enterprise technology. Organizations that do ... approaches for data management can use S4 since there ...
Breaking Biology Technology:His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
Cached News: