HOME >> BIOLOGY >> NEWS
Mucosal-surface immune function discoveries could boost vaccine research

NEW YORK (June 14, 2007) -- In a finding that could have important implications for HIV vaccine research, new research at Weill Cornell Medical College illuminates the ways in which the body prevents its mucosal surfaces from being overwhelmed by bacteria.

Bacteria, most of them "friendly," appear in huge quantities along the intestinal wall, the mouth, nose and throat, and the anal and urogenital tracts. Now, groundbreaking research at Weill Cornell shows that the epithelial cells that line these mucosal surfaces help guide the immune system's efforts to keep bacteria in check.

"That's a wholly new finding, since most biologists think of epithelial cells as a barrier cell -- not as a highly active player in immune function," explains senior researcher Dr. Andrea Cerutti, associate professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College.

"Armed with this knowledge, perhaps we can harness the mechanisms we've discovered to ward off more dangerous pathogens that use mucosal surfaces as their point of entry into the body -- viruses such as HIV, or rotavirus, the diarrhea pathogen that kills millions of children in poor countries each year," he explains.

His team published their findings in the June issue of Immunity.

The new research focused on a type of protective immune system antigen called immunoglobulin A (IgA), which is produced by immune system B cells. In humans, IgA takes two forms -- IgA1 and IgA2.

IgA2, especially, is found in high concentrations along mucosal sites wherever friendly, "commensal" bacteria abound, such as in the intestine where these germs aid in digestion. "Of course, left unchecked, even these bacteria could overrun the gut and cause harm," Dr. Cerutti says. "But somehow the immune system keeps them in balance, giving us the bacteria's benefits with no dangers."

IgA2 is a key player in this balancing act, but since there are
'"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
14-Jun-2007


Page: 1 2 3

Related biology news :

1. Bursts of waves drive immune system soldiers toward invaders
2. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
3. A stepwise retreat: How immune cells catch pathogens
4. Link between immune system and mammary gland could shed new light on breast cancer
5. Researchers discover method for identifying how cancer evades the immune system
6. Invertebrate immune systems are anything but simple, conference finds
7. LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
8. UCLA researchers discover novel pathway that may promote immune system balance
9. Pregnant moms exposure to flu vaccine kick-starts fetal immune system
10. Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism
11. Natural immune-control system may aid treatment of autoimmune disease and tissue rejection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... August 06, 2020 , ... Alucio™, a ... announce that Eric Chen and Jessica Wong have joined the company’s leadership team ... respectively. , Eric Chen heads development efforts for Alucio’s flagship product, Beacon, an ...
(Date:8/3/2020)... ... 2020 , ... Accumen Inc. is helping healthcare get better, ... Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has been ... 10 years. Early in the COVID-19 crisis, we identified supply chain gaps and ...
(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life Sciences ... compliance, announces a new solution to manage regulated workloads on Microsoft Azure. , ... technology stack complies with FDA and global regulations. USDM's new managed service for ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SHREWSBURY, Mass. (PRWEB) , ... July 29, 2020 ... ... clad wire that can combine up to three different materials for use with ... can combine up to three materials to meet specific design requirements, performance, and ...
(Date:7/31/2020)... ... July 30, 2020 , ... Alucio™, ... announced the release of its signature product called Beacon - a content ... other field medical professionals. , Beacon helps MSLs streamline communication and ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
(Date:7/10/2020)... HONG KONG (PRWEB) , ... July 09, 2020 ... ... chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in ... years, the PolyU research team led by Dr MA has been using the ...
Breaking Biology Technology:
Cached News: