HOME >> BIOLOGY >> NEWS
Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations

BETHESDA, Md., Thurs., July 21, 2005 An international team that includes researchers from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), has discovered that mammalian chromosomes have evolved by breaking at specific sites rather than randomly as long thought and that many of the breakage hotspots are also involved in human cancer.

In a study published in the July 22 issue of the journal Science, a team of 25 scientists from the United States, France and Singapore compared the organization of the chromosomes of eight mammalian species: human, mouse, rat, cow, pig, dog, cat and horse. Using sophisticated computer software to align and compare the mammals' genetic material, or genomes, the team determined that chromosomes tend to break in the same places as species evolve, resulting in rearrangements of their DNA. Prior to the discovery of these breakage hotspots, the prevailing view among scientists was that such rearrangements occurred at random locations.

"This study shows the tremendous power of using multi-species genome comparisons to understand evolutionary processes, including those with potential relevance to human disease," said NHGRI Scientific Director Eric D. Green, M.D., Ph.D. "The dog genome map generated by NHGRI researchers and their collaborators played a key role in these new analyses. Furthermore, the team took full advantage of the wealth of human, mouse and rat genome sequence data generated by the recently completed Human Genome Project."

Chromosomes are the threadlike "packages" of DNA located in the nucleus of each cell. When cells divide, a chromosome occasionally breaks and the fragment can get stuck onto another chromosome. In addition, fragments may break off from two different chromosomes and swap places.

Chromosomal breakages, also referred to as translocations, are thought to be important in terms of evolution. When chromosomes break in egg or sperm c
'"/>

Contact: Leslie Saint-Julien
lsaintj@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
21-Jul-2005


Page: 1 2 3

Related biology news :

1. Multi-species herbivore outbreak follows El Nio drought in Panama
2. Unravelling new complexity in the genome
3. One species, many genomes
4. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
5. Charting ever-changing genomes
6. Neutral evolution has helped shape our genome
7. Sea anemone genome provides new view of our multi-celled ancestors
8. Cloning the male genome may help infertile men
9. Mutating the entire genome
10. Exploring the dark matter of the genome
11. New findings challenge established views on human genome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2019)... ... 30, 2019 , ... Keck Graduate Institute (KGI) President Sheldon ... in Bioprocessing and Director of the Amgen Bioprocessing Center, effective July 29, 2019. ... possesses more than 25 years of global experience in bioprocessing,” Schuster said. "She ...
(Date:8/1/2019)... ... 01, 2019 , ... USDM Life Sciences (USDM) announces that Jay Crowley, Vice ... webinar addressing challenges with the upcoming EU MDR IVDR regulations . ... a variety of positions over his 26 years at the FDA, including developing the ...
(Date:7/24/2019)... ... July 24, 2019 , ... NDA Partners ... quality assurance expert with more than 20 years of experience working in scientific ... joined the firm as an Expert Consultant. , Dr. Hartzfeld has experience in ...
Breaking Biology News(10 mins):
(Date:7/23/2019)... , ... July 22, 2019 , ... ... companies with best-in-class services in the fields of 3D tissue imaging , ... learning , Visikol initially started back in 2013 as a products company. These ...
(Date:7/17/2019)... COLLEGE PARK, Md. (PRWEB) , ... July 15, 2019 , ... ... cut DNA so that a certain trait can be removed, replaced, or edited, but ... Maryland, is looking far beyond these traditional applications in his latest publication in Nature ...
(Date:7/11/2019)... ... July 11, 2019 , ... At the most recent ... regenerative therapies to eight military Veterans under the R3 Heroes Program. The Veterans included ... The R3 Heroes Program allow anyone to nominate a military Veteran, teacher or first ...
(Date:7/2/2019)... Calif. (PRWEB) , ... July 02, 2019 , ... Leading ... documentary entitled Animal Pharm: Where Beasts Meet Biotech. The film focuses on regenerative ... wild animals. Animal Pharm was recently included in the Brentwood and ...
Breaking Biology Technology:
Cached News: