HOME >> BIOLOGY >> NEWS
Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

A new study is providing scientists with a better understanding of why some pediatric acute lymphoblastic leukemia (ALL) patients fail to respond to treatment even when existing clinical predictive criteria point towards a positive treatment outcome. The research, published in the April issue of Cancer Cell, is likely to facilitate development of new strategies to combat drug resistance and treatment failure for children with ALL.

Nearly 80% of children with ALL are cured following chemotherapeutic treatment. However, the remaining 20% often exhibit drug resistance and treatment failure that is poorly understood. In some cases, patients are resistant to multiple drugs that have very little structural similarity, suggesting that the mechanisms for drug cross-resistance are probably not the same as mechanisms underlying resistance to a single drug. Dr. William E. Evans from St. Jude Children's Research Hospital and colleagues used a comprehensive genetic screening technique to search for genes that are differentially expressed in ALL cells that demonstrated cross-resistance to two or more commonly used chemotherapeutic agents.

The researchers identified several genes that were differentially expressed in ALL cells that exhibited de novo cross resistance to four widely used antileukemic agents. They went on to investigate the relationship of these genes to treatment outcome in ALL patients and found that expression of the genes was associated with treatment outcome and could be used to identify a subset of patients with a markedly inferior response to treatment. In addition, the findings revealed a previously unrecognized phenotype characterized by discordant resistance to two widely used and mechanistically distinct antileukemic agents and provided new information about the cellular mechanisms involved in disparate response to these drugs.

Specific genetic signatures related to ALL treatment failure and chemotherapeutic cross-resistance w
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
18-Apr-2005


Page: 1 2

Related biology news :

1. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
2. New way to target and kill antibiotic-resistant bacteria found
3. First all-African produced genetically engineered maize is resistant to maize streak virus
4. Malaria-resistant mosquitoes battle disease with molecular warhead
5. Wellcome Trust and GlaxoSmithKline announce partnership to target drug-resistant hospital infections
6. Arming the fight against resistant bacteria
7. Researchers uncover protection mechanism of radiation-resistant bacterium
8. Will the plague pathogen become resistant to antibiotics?
9. Trojan horse strategy defeats drug-resistant bacteria
10. Breakthrough vaccine to treat chemo-resistant ovarian cancer
11. Protein discovery targets antibiotic-resistant bacteria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... ... July 09, 2019 , ... Murrieta Genomics, a launch ... program. The founder and CEO of Tx Genetic, Helen Harrison, has spent several ... from epithelial connective tissue disorders. , “We are pleased and excited to join ...
(Date:6/25/2019)... ... 25, 2019 , ... ActX has launched a medical genetic ... 23andMe, customers can get access to professionally reviewed genetic screening similar to what ... and Health + Ancestry customers., With the ActX + 23andMe service, both 23andMe ...
(Date:6/16/2019)... ... June 14, 2019 , ... ... to lecture at the fifth annual Neodent World Congress. Attended by thousands of ... progress and latest advancements in the world of dentistry. The three-day event featured ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... ... on Data Integrity on July 08-09, 2019 in Boston, MA. This peer recommended ... medical device organizations. , The training will kick off with a compendial treatment ...
(Date:5/15/2019)... , ... May 15, 2019 , ... Milton Hershey School® ... recognition for his work within the biomedical industry, where he is changing lives by ... devices. , “William Harding epitomizes the vision of our founders – Milton and ...
(Date:5/7/2019)... ... May 06, 2019 , ... "The new ... number of repositories being asked to store cellular products being used in ... contributors who are world leaders, who have shared their expertise in building and ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of ... device and food industries. Access to all webinars is free, so be sure to ... your field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL ...
Breaking Biology Technology:
Cached News: