HOME >> BIOLOGY >> NEWS
Mutation may raise prostate-cancer risk in African Americans

COLUMBUS, Ohio Researchers have identified a gene mutation that may increase the risk of prostate cancer up to three times in African-American men with a family history of the disease.

The study, by scientists at 13 research centers, found that mutations in a gene known as EphB2 occurred in 15 percent of African-American men with a strong family history of prostate cancer. The mutation was found in only 5 percent of African-American men with no family or personal history of the disease and in less than 2 percent of European-American men with no history of the disease.

Prostate cancer rates are extremely high in African-American men. They develop the disease 60 percent more often than do European Americans, and they are almost two and half times more likely to die of the disease.

Until now, no gene mutations have been identified that contribute to hereditary prostate cancer and prostate-cancer susceptibility specifically in African-American men.

The findings are published online in the Sept. 9, 2005, issue of the Journal of Medical Genetics.

"This is the first gene mutation to be associated with familial prostate cancer in African-American men," says first author Rick A. Kittles, associate professor of molecular virology, immunology and medical genetics and a researcher with the Human Cancer Genetics program at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

"Next, we must learn more about how this mutation contributes to cancer, and we must screen for the mutation in a much larger group of African-American men with prostate cancer to verify its association with the disease."

Then, says Kittles, a specialist in prostate-cancer genetics in African Americans, "perhaps we can begin using this mutation to help estimate prostate-cancer risk in African-American men."

The findings are the first to come out of the African-A
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
20-Sep-2005


Page: 1 2

Related biology news :

1. Mutation improves memory, may lead to memory-enhancing pill
2. Mutation in HNF4A associated with an increase in birthweight and macrosomia
3. Mutations point the way to new leukemia drugs
4. Mutation in tumor suppressor gene causes pancreatic islet cells to reproduce
5. Mutation in deafness gene can help heal wounds and prevent infection
6. Mutation in blood stem cells provides clues to cancer development
7. Mutation in a single gene switches a fungus-grass symbiosis from mutualistic to antagonistic
8. Mutation in brain cells of descendants of Abraham Lincoln suggest he suffered from movement disorder
9. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
10. Mutations in NOTCH1 gene cause aortic valve disease
11. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2019)... ... June 24, 2019 , ... According to the World ... the four most common STDs: chlamydia, gonorrhea, trichomoniasis (or "trich") and syphilis. And that’s ... and bisexual African American men accounted for the largest number of HIV diagnoses (9,807), ...
(Date:6/18/2019)... Calif. (PRWEB) , ... June 18, 2019 , ... ... multi-GPU deep learning cloud solutions, today introduced Data Science Workstations-as-a-Service as part of ... workstation hardware from BOXX Technologies, Cirrascale Data Science Workstations feature NVIDIA® Quadro RTX™ ...
(Date:6/14/2019)... Va. (PRWEB) , ... June 14, 2019 , ... Molecular ... is estimated to be $8,760 million in 2019. Major segments that are expected ... These are all broken out and forecasted as segments in Kalorama’s The World ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 10, 2019 , ... Advancements with ... upcoming episode, scheduled to broadcast 4Q/2019. Check your local listings for more information. ... viewers about how its technology facilitates laboratories to improve efficiency and quality of ...
(Date:6/6/2019)... , ... June 05, 2019 , ... WCCT Global, ... medical device industries, announced today that they will be receiving 3 awards at the ... CA. WCCT received 2 awards in the categories of overall Quality and Compatibility (Access ...
(Date:5/31/2019)... ... May 30, 2019 , ... A study released ... delivery system for the sustained release of human placental stem cell (HPSC)-derived conditioned ... able to deliver CM into the injured kidney, where it helped restore function ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak Detection Associates (LDA), the ... Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce the go-live ... LDA’s ability to communicate directly with the marketplace; serving as a destination to ...
Breaking Biology Technology:
Cached News: