HOME >> BIOLOGY >> NEWS
Mysterious molecules begin to yield their secrets

A team of investigators at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF) have discovered a way to screen hundreds and potentially thousands of "noncoding" RNA molecules to discover their functions within cells.

Unlike traditional RNA, which is copied from DNA to code for a protein, these noncoding RNA molecules are never translated into proteins. But noncoding does not mean uninteresting. There are tens of thousands of noncoding RNA molecules inside human cells, and even if only one percent is functional, that's still hundreds of molecules that may be participating in the control of cellular functions.

In this week's issue of the journal Science, the Scripps Research and GNF team reports on an experimental strategy for searching for these undiscovered functions. As a proof of principal, the scientists screened a library of noncoding RNAs, selected one that seemed to play a cellular role, and performed further experiments to prove that it does.

"We have only just hit the tip of the iceberg," says Professor Peter G. Schultz, Ph.D., who holds the Scripps Family Chair and is a professor in the department of Chemistry and The Skaggs Institute of Chemical Biology at Scripps Research. "There's a whole world of this noncoding RNA."

A Stranger in the Protein Encoding Land

Noncoding RNA has long been regarded as something of a stranger in the protein encoding land of RNA. It falls outside the purview of traditional molecular biologists, who once adhered to a concept called the "central dogma," which held that DNA genes are transcribed into RNA transcripts that are then translated into proteins.

The fact that there is non-coding RNA within cells has been known for several years, but it has only been recently that scientists have begun to appreciate noncoding RNA. Many reports have appeared in the scientific literature describing this RNA that does not encode pro
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-775-4080
Scripps Research Institute
1-Sep-2005


Page: 1 2 3

Related biology news :

1. Mysterious neural noise actually primes brain for peak performance
2. Small molecules may explain psoriasis
3. Magnetic computer sensors may help study biomolecules
4. Hamilton College researchers discover molecules with potential to treat breast cancer
5. Early exposure to indoor fungus molecules may protect infants against future allergies
6. Minuscule molecules pack a powerful punch
7. Penn scientists engineer small molecules to probe proteins deep inside cell membrane
8. LED array signals successful binding of drug-delivery molecules to DNA
9. New synthetic self-assembling macromolecules mimic nature
10. Study reveals how some molecules inhibit growth of lung cancer cells
11. Leukemia drug turns mini-molecules up, cancer genes down

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2019)... ... February 26, 2019 , ... ... In her position as Account Manager, Ms. Baptiste demonstrated her ability to advocate ... experience. Ms. Baptiste was responsible for partnering with both the Strategic Development team ...
(Date:2/22/2019)... ... February 21, 2019 , ... Clean label food is ... when creating natural foods and beverages. It is quite common to spot consumers running ... meat products are not immune to this label scrutiny. , More than ever, ...
(Date:2/22/2019)... ... February 21, 2019 , ... The ... executed a research agreement establishing a collaborative program to work toward applications of ... develop new radiopharmaceutical lead candidates and will explore Fuzionaire Dx’s platform as a ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... 14, 2019 , ... Open registration for the Case Management ... of Case Management,” continues as CMSA makes plans to host the annual event ... management industry conference serving the educational and networking needs of case and care ...
(Date:3/14/2019)... (PRWEB) , ... March 13, 2019 , ... ... its 2019 ISPE Europe Biotechnology Conference , taking place in Brussels, Belgium ... biotechnology best practices, technical and operational solutions, and innovative approaches. , “Biopharmaceuticals ...
(Date:3/12/2019)... (PRWEB) , ... March 12, 2019 , ... ... preparation and epigenetics research, has launched its third generation long-fragment DNA shearing innovation, ... generation instrument with a user-friendly interface, automated processing, and the ability to ...
(Date:3/9/2019)... ... March 07, 2019 , ... ACEA Biosciences ... development and commercialization of high performance, cutting-edge cell analysis platforms for life science ... GLP-certified expertise in cardiovascular pharmacology and electrophysiology, are announcing a partnership to provide ...
Breaking Biology Technology:
Cached News: