In the first set of grants, 11 teams will work to develop "near term" technologies that, within five years, are expected to provide the power to sequence a mammalian-sized genome for about $100,000. In the second set, seven groups will take on the longer-term challenge of developing revolutionary technologies to realize the vision of sequencing a human genome for $1,000 or less. The approaches pursued by both sets of grants have many complementary elements that integrate biochemistry, chemistry and physics with engineering to enhance the whole effort to develop the next generation of DNA sequencing and analysis technologies.
"These projects span an impressive spectrum of novel technologies from sequencing by synthesis to nanopore technology. Many of these new approaches have shown significant promise, yet far more exploration and development are needed if these sequencing technologies are to be useful to the average researcher or physician," said Jeffery Schloss, Ph.D., NHGRI's program director for technology development. "We look forward to seeing which of these technologies fulfill their promise and achieve the quantum leaps that are needed to take DNA sequencing to the next level."
"$100,000" Genome Grants
NHGRI's "Near-Term Development for Genome Sequencing" grants will support research aimed at sequencing a human-sized genome at 100 times lower cost than is possible today. There is strong potential that, five years from now, some of these technologies will be at or near commercial availability. Grant recipients and their approximate total funding are:
Stevan B. Jovanovich, Ph.D., Microchip Biotechnologies Inc., Fremont, Calif.
$6.1 million (3 years)
"Microbead INtegrated DNA Sequencer (MINDS) System"
Retaining the advantages of current DNA sequencing methods, including well-developed community infrastructure, commercial availability of reagents and existing analysi
Contact: Geoff Spencer
NIH/National Human Genome Research Institute