HOME >> BIOLOGY >> NEWS
NIAID supports research into etiology of fungal-induced inflammation in chronic sinusitis

ce, associate professor at VBI, will head the work at VBI in collaboration with VBI assistant professor Dharmendar Rathore. Researchers at Mayo, including clinical assistant professor Jens Ponikau, who is now at the University at Buffalo School of Medicine & Biomedical Sciences, and Hirohito Kita, professor of Immunology and the director of the Allergic Diseases Laboratory at Mayo, carried out extensive research at the Mayo Clinic which identified a fungal origin for CS.

Accentia Biopharmaceuticals is commercializing a diagnostic and developing a treatment for CS based on the published technology discovered at the Mayo Clinic. Investigators at Mayo discovered that a ubiquitous, normally innocuous mold, Alternaria, colonizes the mucus of the nose and sinus of virtually everybody, but in patients with CS, this non-invasive mold elicits an eosinophilic inflammatory response characterized by release of eosinophil major basic protein (eMBP) in the mucus, which then damages the mucosal epithelial lining of the nose and sinuses and leads to the inflammatory mucosal changes characteristic of CS.

Dr. Jens Ponikau, Assistant Professor of Clinical Otolaryngology, University at Buffalo, commented: Research supported by the National Institutes of Health had previously shown that CS patients have an exaggerated immune response to certain fungi, specifically Alternaria species. The patients reacted to the fungi with the production of the inflammatory mediators, which are crucial for the inflammation in CS, whereas healthy subjects were not reacting. The renewal of the NIH grant will allow Dr. Kita and Dr. Lawrence to further pinpoint the mechanism by which the fungus causes the inflammation, and specifically what fungal products are involved. Both are important milestones to deepen our understanding about CS, and will help us to better understand the mechanism of action of newer treatment approaches, such as anti-fungal therapy.

As previously an
'"/>

Contact: Janet Vasquez
jvasquez@investorrelationsgroup.com
212-825-3210
The Investor Relations Group
1-Jun-2007


Page: 1 2 3

Related biology news :

1. US government $20M NIAID grant funds Proteome Systems catalytic scavenger compounds
2. ESA open-source software supports Germanys TerraSAR-X
3. National Science Foundation supports UCR study of polar lake life forms
4. Hofmeyr skull supports the Out of Africa theory
5. USC study in Nature Genetics supports a stem cell origin of cancer
6. AIUM supports FDA decision to deny over-the-counter use of handheld doppler fetoscopes
7. Conference supports minority students to pursue biomedical careers
8. Study supports urgent need for worldwide ban on lead-based paint
9. Slow-frozen people? Latest research supports possibility of cryopreservation
10. Award supports Virginia Tech research to reduce vehicle emissions, create biofuel
11. Taxpayer Alliance supports senate bill broadening access to federal research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2017)... 2017 Former 9/11 Commission border counsel and ... Janice Kephart of Identity Strategy Partners, LLP, today ... "Executive Order: Protecting the Nation From Foreign Terrorist ... "As President Trump,s ,Travel Ban, Executive Order gains ... banned the travel ban, it is important that our ...
(Date:2/8/2017)... 2017  Aware, Inc. (NASDAQ: AWRE ), a ... results for its quarter and year ended December 31, 2016. ... was $3.9 million compared to $6.9 million in the same ... 2016 was $0.6 million compared to $2.6 million in the ... of 2016 was $0.5 million, or $0.02 per diluted share, ...
(Date:2/7/2017)... MINNETONKA, Minn. , Feb. 7, 2017   ... that supports the entire spectrum of clinical research, is ... iMedNet , its innovative, highly flexible and ... iMedNet customers. iMedNet is a ... only provides Electronic Data Capture (EDC), but also delivers ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... , ... February 21, 2017 , ... ... organizations to build connected digital health applications, announced a partnership with Redox, a ... to seamlessly connect to many clinical systems while keeping data secure in the ...
(Date:2/21/2017)... ... February 21, 2017 , ... The medical potential of stem cells ... multiple areas of medicine, due to their differentiating characteristics. Stem cells are unique as ... ability to be induced to become tissue or organic-specific cells with special functions. ...
(Date:2/21/2017)... VANCOUVER, British Columbia , Feb. 21, 2017  OncoGenex ... apatorsen results from two randomized Phase 2 clinical trials were ... Genitourinary Cancers Symposium, held February 16 th - 18 th ... trials in bladder and prostate cancers demonstrated apatorsen was well-tolerated ... treatments. ...
(Date:2/21/2017)...   Invitae Corporation (NYSE: NVTA), one of ... members of the company,s management team will present at ... on Monday, March 6, 2017 at approximately 4:00 p.m. ... Massachusetts . The live, listen-only ... the investors section of the company,s website at ...
Breaking Biology Technology:
Cached News: