HOME >> BIOLOGY >> NEWS
NIEHS researchers identify enzyme critical in DNA replication

In this weeks issue of Science, researchers from the National Institute of Environmental Health Sciences (NIEHS) and Ume University in Sweden report an important discovery about a critical new role that an enzyme called DNA polymerase epsilon plays in replicating DNA in higher organisms such as yeast and perhaps even humans.

The study places us one step closer to understanding the origins of genome instability that underlie certain environmental diseases in humans, said NIEHS Director David A. Schwartz, M.D. NIEHS is part of the National Institutes of Health.

The research was conducted by Zachary Pursell, Ph.D. and Thomas A. Kunkel, Ph.D., at NIEHS in collaboration with Erik Johansson, Ph.D. and colleagues at Ume University.

The researchers used an innovative strategy to demonstrate that in bakers yeast, DNA polymerase epsilon has a primary role in replicating the leading strand of DNA. DNA polymerase epsilon was found to be a key determinant of genome stability and of cellular responses to DNA damage resulting from exposures to environmental stress.

The researchers built on fundamental discoveries on the structure and replication of DNA made by Nobel laureates James Watson, Francis Crick and Arthur Kornberg.

When Watson and Crick first described the structure of DNA in 1953, they pointed out that the two DNA strands, which are referred to as leading and lagging, pair with each other to form the now familiar double helix.

Shortly thereafter, Kornberg and colleagues discovered the first enzymes capable of replicating DNA, a process required to make new genomes for cell division. These enzymes, called DNA polymerases, were shown to copy the two DNA strands in only one of two possible directions. One strand of the double helix must be replicated first by a dedicated leading strand polymerase, followed slightly thereafter by replication of the lagging strand by a different polymerase.

'"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
5-Jul-2007


Page: 1 2

Related biology news :

1. NIEHS allocates $74 million to study environmental causes of disease
2. Two at Yale named outstanding new environmental scientists by NIEHS
3. Columbia University receives $16.9 million NIEHS award to study arsenic in ground water
4. NIEHS researchers link gene variation to coronary heart disease
5. NIEHS Director unveils new strategic plan for environmental health sciences
6. NIEHS awards $37 million to train emergency and hazardous waste workers
7. NIEHS launches website with information for assessing environmental hazards from Hurricane Katrina
8. A role for public and scientists in NIEHS research plan
9. NIEHS to develop new RNAi library to help fight disease
10. Innovative tagging technique may help researchers better protect fish stocks
11. Penn researchers discover how key protein stops inflammation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2020)... (PRWEB) , ... February 07, 2020 , ... ... regulatory consulting firm for the natural health product, nutraceutical and dietary supplement industries, ... long been a leader in regulatory expertise and research pertaining to probiotics. We ...
(Date:2/5/2020)... , ... February 05, 2020 , ... ... to bring greater ease, efficiency and insight to sample processing within laboratories. ... and biotech laboratories conducting research in various fields, LabKey Sample Manager has been ...
(Date:1/29/2020)... ... January 29, 2020 , ... INDIGO Biosciences, ... testing solutions, has announced a record earnings year for 2019. With final numbers ... than a twenty percent increase in revenue and a thirty percent increase in ...
Breaking Biology News(10 mins):
(Date:1/22/2020)... ... January 21, 2020 , ... ... Taylor as Southern Midwest Region Industrial and Institutional (I&I) Account Manager. Darrell will ... , Darrell brings over 30 years of sales experience working across ...
(Date:1/10/2020)... ... 09, 2020 , ... GenScript Biotech Corp., one of the ... on Jan. 14 in San Francisco, coinciding with the JP Morgan Healthcare Conference ... China Market," will feature gene and cell therapy leaders in industry, academia and ...
(Date:1/7/2020)... ... January 06, 2020 , ... ... World at The Fletcher School at Tufts University, is pleased to announce that ... grant will be administered by Tufts University, and will help to expand the ...
(Date:12/30/2019)... ... December 30, 2019 , ... Leak Detection Associates (LDA), ... Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries is pleased to announce the ... program specific to the custom-built helium leak testing systems it designs and manufactures. ...
Breaking Biology Technology:
Cached News: