HOME >> BIOLOGY >> NEWS
NIEHS researchers link gene variation to coronary heart disease

New research at the National Institute of Environmental Health Sciences, part of the National Institutes of Health, found that a common genetic variation makes some people more susceptible to coronary heart disease (CHD). Caucasians who carry this gene variation are approximately 1.5 times more likely to have a CHD event, such as a heart attack, than those who do not have the gene variation. Gene variations are also known as polymorphisms. About 15 percent of all Caucasians have this particular polymorphism.

"We found that Caucasians who carry this polymorphism, named K55R, were at significantly higher risk of coronary heart disease, independent of other risk factors, like cigarette smoking, diabetes, and hypertension. We did not observe the same association in African Americans who had the K55R polymorphism," said Craig Lee, Pharm.D., a researcher at NIEHS and lead author on the study. The study is published in the Volume 15, No. 10 issue of Human Molecular Genetics.

This research showed that Caucasians with the K55R polymorphism had an accelerated break down of beneficial fatty acids called epoxyeicosatrienoic acids or EETs, which are known to play a protective role in the cardiovascular system. These fatty acids help to lower blood pressure, prevent blood clotting and fight inflammation.

The K55R polymorphism is a naturally-occurring, inherited variation of EPHX2--the epoxide hydrolase gene. EPHX2 generates an enzyme that rids the body of beneficial EET fatty acids, as part of normal human metabolism. In people with the K55R polymorphism, this normal process is accelerated and even more of the protective EETs are lost.

"This research builds on a body of evidence suggesting the importance of this gene and its fatty acid products in the cardiovascular system," said David A. Schwartz, M.D., NIEHS Director. "It also suggests that this metabolic pathway may serve as a useful target for the prevention or treatment of cardiovascu
'"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
11-May-2006


Page: 1 2 3

Related biology news :

1. NIEHS researchers identify enzyme critical in DNA replication
2. NIEHS allocates $74 million to study environmental causes of disease
3. Two at Yale named outstanding new environmental scientists by NIEHS
4. Columbia University receives $16.9 million NIEHS award to study arsenic in ground water
5. NIEHS Director unveils new strategic plan for environmental health sciences
6. NIEHS awards $37 million to train emergency and hazardous waste workers
7. NIEHS launches website with information for assessing environmental hazards from Hurricane Katrina
8. A role for public and scientists in NIEHS research plan
9. NIEHS to develop new RNAi library to help fight disease
10. Innovative tagging technique may help researchers better protect fish stocks
11. Penn researchers discover how key protein stops inflammation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... A new study published in Fertility and ... in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort study ... comparing the results from the fresh and frozen transfer cohorts, the authors of ...
(Date:10/10/2017)... CA (PRWEB) , ... October ... ... a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today ... of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
Breaking Biology Technology:
Cached News: