HOME >> BIOLOGY >> NEWS
NMR advance relies on microscopic detector

Detecting the molecular structure of a tiny protein using nuclear magnetic resonance (NMR) currently requires two things: a million-dollar machine the size of a massive SUV, and a large sample of the protein under study.

Now, researchers from MITs Center for Bits and Atoms report the development of a radically different approach to NMR. The new highly sensitive technique, which makes use of a microscopic detector, decreases by several orders of magnitude the amount of protein needed to measure molecular structure.

The new technology could ultimately lead to the proliferation of tabletop NMR devices in every research laboratory and medical office. Among other things, such devices could prove invaluable in diagnosing a variety of diseases.

"Its revolutionary," said Shuguang Zhang, one of the authors and associate director of MITs Center for Biological Engineering. "Its not just incremental progress."

The research team reports the work in the online and print editions of the Proceedings of the National Academy of Sciences the week of May 14. Lead author Yael Maguire, a former MIT graduate student who earned his Ph.D. for this work, will give a talk on it May 16 at the VII European Protein Symposium in Stockholm.

NMR, along with X-ray crystallography, is commonly used to determine the structure of proteins and other molecules. NMR probes normally consist of a coil that surrounds the sample being studied. The coil creates a magnetic field that interacts with the nuclear spin of atoms in the sample, and those interactions reveal how the atoms are connected.

With current NMR machines, you need about 1017 (more than a million billion) molecules of a protein to determine its molecular structure. Some researchers have tried to make tiny coils to study smaller samples, but it has proven very difficult to scale these to small sizes to analyze tiny samples and to create high throughput methods.

Instead, re
'"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
15-May-2007


Page: 1 2 3 4

Related biology news :

1. U-M, Israeli scientists report major advance in search for genes associated with colon cancer
2. Study advances vCJD prion detection
3. New dynamic brace developed to advance clubfoot treatment
4. New genetic test developed at Emory advances detection and diagnosis of muscular dystrophy
5. Scientists call for global push to advance research in synthetic biology
6. NSF funding to advance research on interplay between biology and society
7. SNM advances professional definition for molecular imaging
8. New treatment increases life time expectancy of patients suffering from advanced liver cancer
9. New research advances energy efficiency, safety and performance of public transit
10. Heavy multivitamin use may be linked to advanced prostate cancer
11. InfoSNM highlights advances in computer, information sciences for molecular imaging

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: