HOME >> BIOLOGY >> NEWS
NYU's Center for Comparative Functional Genomics helps to unravel the function of microRNAS

could be part of genes that drive organismal diversity. In particular, one microRNA was shown to have many more targets in flies than in mammals, and this microRNA was predicted to contribute to the regulation of fly oogenesis, a process that is highly different between flies and mammals.

The paper may be obtained at compbiol.plosjournals.org/

In carrying out the study, the Rajewsky group developed "PicTar," a new algorithm for the identification of microRNA target sites in the genome (published in Nature Genetics, spring 2005). The PicTar algorithm was based on a paper by Rajewsky, who also holds an affiliated appointment at NYU's Courant Institute of Mathematical Sciences, and his collaborator Nicholas Socci published in Developmental Biology in 2004, where they discovered key components of microRNA--target site recognition. When applying PicTar to seven vertebrate genomes, their Nature Genetics study found that each microRNA regulates, on average, 200 different human transcripts and that multiple microRNAs can coordinate their activities to regulate a specific target genes. Altogether, they showed that 20 to 30 percent of all vertebrate genes are likely to be regulated by microRNAS. The paper contains detailed genome-wide target predictions for all human microRNAs as well as tissue-specific predictions. Several predictions were validated experimentally by Rajewsky's collaborators at Rockefeller University. The findings demonstrate an unforeseen, staggering complexity of gene regulation executed by microRNAs on a genome-wide level.

Finally, collaborating with researchers at Rockefeller University, Lund University (Sweden), and Oxford University, Rajewsky recently helped to unravel the function of a microRNA gene that was shown to regulate the secretion of insulin in the pancreas. The findings, which for the first time defined a physiological function for a mammalian micro
'"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
30-Jun-2005


Page: 1 2 3

Related biology news :

1. NYUs Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
2. Psychiatric Genomics Center established at Cold Spring Harbor Laboratory
3. Energy department selects 3 Bioenergy Research Centers for $375 million in federal funding
4. Woods Hole Research Center scientists study impacts of industrial logging in Central Africa
5. Innovative smallpox vaccine research study to be conducted at Case Medical Center
6. CSHL selected for odENCODE Data Coordination Center
7. Woods Hole Research Center scientists using remote sensing tools to predict bird species richness
8. Understanding the global carbon budget -- Woods Hole Research Center expert provides insights
9. NIH establishes Center of Excellence for influenza research at Mount Sinai
10. St. Jude named a Center of Excellence in flu research
11. New Geisinger Health System building green Center for Health Research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: