HOME >> BIOLOGY >> NEWS
Nano-particle research will benefit inhaler-users

Patients suffering from conditions as diverse as asthma and diabetes could benefit from research at Cardiff University to improve the effectiveness of drugs taken through spray inhalers.

Scientists in the Welsh School of Pharmacy are working on new nano-particle drug formulations for inhalers, and enhancers to improve the effectiveness of proteins, such as insulin, delivered to the lung.

"Drugs delivered through inhalers are usually either in a suspension (as particles dispersed in liquid), or in a solution (when the drug is dissolved in the liquid)," explained Dr James Birchall. "However, there are problems with both methods - a suspension can lead to sediment in the inhaler and less of the drug reaching the target area of the lung, while solutions present problems in dissolving the drug in the inhaler propellant liquid and can make the drug itself less stable."

The Cardiff team's approach is to prepare the drug in nano-particle form ensuring the correct dosage reaches the lung and the drug retains its stability, and providing the possibility of slowing the release of the drug in the lung for longer therapeutic effect.

This could lead to the possibility of more drugs being administered effectively by inhaler, rather than by tablet or injection.

Meanwhile, the team is also developing a process which uses a naturally occurring substance to enhance the absorption of insulin. Initial studies suggest insulin is absorbed three to four times more effectively by this process.

Now Dr Birchall and his colleague Dr Glyn Taylor of The Pulmonary Research Group aim to combine the two innovations to prolong and maximise the absorption effect.

"These two technologies could make a huge improvement in the effectiveness of spray inhalers for users suffering from a wide range of illnesses and conditions," said Dr Birchall.


'"/>

Contact: Dr James Birchall
BirchallJC@cardiff.ac.uk
44-292-087-5815
Cardiff University
29-Apr-2005


Page: 1

Related biology news :

1. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
2. Saudi Arabias KAUST names WHOI first research partner
3. Multinational research: protecting ecology means understanding people, too
4. Newly created cancer stem cells could aid breast cancer research
5. Carnegie Mellons Peter Adams receives EPA research grant
6. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
7. Innovative tagging technique may help researchers better protect fish stocks
8. Penn researchers discover how key protein stops inflammation
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. ASU researchers partner with UOP to make biofuel for military jets a reality
11. Einstein researchers prototype vaccine could provide improved protection against tuberculosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... ... January 31, 2019 , ... ... NC, providing full, customizable clinical research services across multiple therapeutic areas, announced ... for early stage life science entrepreneurs in the Research Triangle region of ...
(Date:1/25/2019)... ... January 24, 2019 , ... GrowthZone, Inc., ... Survey. The report indicates membership growth in some sectors and decreasing membership among ... received responses from over 500 association professionals across North America. , “This ...
(Date:1/20/2019)... , ... January 16, 2019 , ... As the leader ... through the introduction of its own liver 3D cell culture models. In an effort ... models, protocols and validation criteria so that any researcher can replicate these models for ...
Breaking Biology News(10 mins):
(Date:2/6/2019)... ... February 05, 2019 , ... Firmex announced today that ... to acquire Firmex, one of the fastest-growing and most widely-used providers of virtual ... firm. Debt financing was provided by the Bank of Montreal. , Headquartered in ...
(Date:2/2/2019)... ... January 31, 2019 , ... Dust off your Doc Martens, Virun ... the Nuriv 2019 Expo West Music and Tech Festival at the ESports Arena in ... in the natural foods, beverages, and dietary supplement industries, the Nuriv Music and Tech ...
(Date:2/2/2019)... ... February 01, 2019 , ... Biomatlante, a world ... its new CEO, Julien Dert, being effective on February 1st, 2019. , Graduated ... and management, in which more than 12 years in the Medical Device industry. ...
(Date:1/30/2019)... ... January 29, 2019 , ... ... Manufacturing Organization (CDMO) serving the global biopharmaceutical and biotechnology industries with sites in ... million backed by multiple global investors lead by China's State Development & Investment ...
Breaking Biology Technology:
Cached News: