HOME >> BIOLOGY >> NEWS
Nanoparticles carry chemotherapy drug deeper into solid tumors

A new drug delivery method using nano-sized molecules to carry the chemotherapy drug doxorubicin to tumors improves the effectiveness of the drug in mice and increases their survival time, according to a study published online June 26 in the Journal of the National Cancer Institute.

In the past, similar drug carriers have improved targeted delivery of the drugs and reduced toxicity, but they sometimes decreased the drugs ability to kill the tumor cells. Using a new drug carrier, Ning Tang of the Chinese Academy of Sciences in Beijing and colleagues compared tumor growth and survival in mice that were given doxorubicin in the nanocarriers or on its own.

Doxorubicin delivered by nanocarriers was more effective in preventing tumor growth than free doxorubicin, and the mice receiving this treatment method lived longer and had fewer toxic side effects.

Encapsulation of doxorubicinincreased its accumulation and penetration in tumors in terms of both the percentage of cells that were reached by the drug and the intracellular levels that were attained, the authors write.

In an accompanying editorial, Matthew Dreher, Ph.D., of the National Institutes of Health in Bethesda, Md., and Ashutosh Chilkoti, Ph.D., of Duke University in Durham, N.C., discuss the future of drug delivery, which they think should focus on three important research areasdrug combinations, targeting, and integration.

The study by Tang [and colleagues] is a simple but effective demonstration of the benefits of integration of a drug with an appropriate carrier to yield a striking gain in efficacy, the authors write. May the days of pharmacological missiles that miss their target and friendly fire that kills patients soon be over!


'"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
26-Jun-2007


Page: 1

Related biology news :

1. Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
2. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
3. Little lifesavers -- Nanoparticles improve delivery of medicines and diagnostics
4. Nanoparticles for delivery of prostate cancer treatment
5. MIT, Brigham: Nanoparticles armed to combat cancer
6. Nanoparticles create biocompatible capsules
7. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
8. New model for autism suggests women carry the disorder and explains age as a risk factor
9. New highways carry pathogens and social change in Ecuador
10. Non-steroidal anti-inflammatory drug increases liver damage in mice carrying mutant human gene
11. Neural stem cells derived from human embryonic stem cells carry abnormal gene expression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2019)... ... March 13, 2019 , ... Sleep problems constitute a global epidemic that threatens ... world’s population. One billion people worldwide suffer from sleep apnea - a ... 80 percent of whom go undiagnosed. Today, Beddr , the sleep health technology ...
(Date:3/9/2019)... WENDELSHEIM, De. and OAKLAND, Calif. (PRWEB) , ... ... ... of autoimmune, allergy, food intolerance, and infectious disease diagnostics and automation – is ... website is an online quality control resource giving customers access to lot-specific information, ...
(Date:3/9/2019)... MILWAUKEE, Wis. (PRWEB) , ... March 08, 2019 ... ... of Cancer (SITC) is pleased to announce a new initiative focused on women ... is a one-and-a-half day, free program that seeks to celebrate and empower emerging ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... March 13, 2019 , ... Murrieta Genomics , the genomic sequencing business ... and broader business experience to bear as genomic sequencing startups build their business models. ... and expertise that our Advisory Board brings to the table. Many of these experts ...
(Date:3/11/2019)... TORONTO (PRWEB) , ... March 11, 2019 , ... In ... be considered to improve your clinical trial efficiency and experience. Participants will learn how ... with clinical IRT expertise to ensure that the simple or complex randomization scheme is ...
(Date:3/5/2019)... ... 2019 , ... Modality Solutions, an Inc. Verified Company, ... network experts, and experienced integrated staffing professionals. , Upon receiving Modality ... program, Inc. editors independently reviewed the Houston-based cold chain management company to validate ...
(Date:2/22/2019)... ... February 20, 2019 , ... Murrieta Genomics ... in the rapidly growing NGS (Next Generation Sequencing) field, have announced a partnership ... incubator. , "As an innovation center and idea incubator, we are always looking ...
Breaking Biology Technology:
Cached News: