HOME >> BIOLOGY >> NEWS
Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery

Researchers at the University of California, Santa Barbara have discovered that attaching polymeric nanoparticles to the surface of red blood cells dramatically increases the in vivo lifetime of the nanoparticles. The research, published in the July 07 issue of Experimental Biology and Medicine, could offer applications for the delivery of drugs and circulating bioreactors.

Polymeric nanoparticles are excellent carriers for delivering drugs. They protect drugs from degradation until they reach their target and provide sustained release of drugs. Polymeric nanoparticles, however, suffer from one major limitation: they are quickly removed from the blood, sometimes in minutes, rendering them ineffective in delivering drugs.

The research team, led by Samir Mitragotri, a professor of chemical engineering, and Elizabeth Chambers, a recent doctoral graduate, found that nanoparticles can be forced to remain in the circulation when attached to red blood cells. The particles eventually detach from the blood cells due to shear forces and cell-to-cell interactions, and are cleared from the system by the liver and spleen. Red blood cell circulation is not affected by attaching the nanoparticles.

Attachment of polymeric nanoparticles to red blood cells combines the advantages of the long circulating lifetime of the red blood cell, and their abundance, with the robustness of polymeric nanoparticles, said Mitragotri. Using red blood cells to extend the circulation time of the particles avoids the need to modify the surface chemistry of the entire particle, which offers the potential to attach chemicals to the exposed surface for targeting applications.

The researchers have learned that particles adhered to red blood cells can escape phagocytosis because red blood cells have a knack for evading macrophages. Nanoparticles arent the first to be piggybacking on red blood cells; the strategy has already been adopted by certain bacteria, such as
'"/>

Contact: Dr. Samir Mitragotri
samir@engineering.ucsb.edu
805-893-7532
Society for Experimental Biology and Medicine
27-Jun-2007


Page: 1 2

Related biology news :

1. Nanoparticles carry chemotherapy drug deeper into solid tumors
2. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
3. Little lifesavers -- Nanoparticles improve delivery of medicines and diagnostics
4. Nanoparticles for delivery of prostate cancer treatment
5. MIT, Brigham: Nanoparticles armed to combat cancer
6. Nanoparticles create biocompatible capsules
7. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
8. Nanotech hitchhikers in blood
9. The hitchhikers guide to altruism -- Study explains how costly traits evolve
10. Microbes hitchhike across Atlantic on desert dust
11. Viral hitchhiker inhibits Wolbachia bacterias ability to proliferate

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2019)... FORT WORTH, Texas (PRWEB) , ... January 02, ... ... 2019 catalog. This release is particularly noteworthy, as the life science tools and ... company’s history, it is offering a catalog. The catalog features not just part ...
(Date:12/25/2018)... ... December 24, 2018 , ... Researchers at ... discovered a new use for a long-standing computational concept known as “blacklisting,” which ... files and messages. Using blacklisting as a filter to single out genetic variations ...
(Date:12/19/2018)... (PRWEB) , ... December 19, 2018 , ... ... of a new study in Arthroscopy evaluating the use of novel ... cuff tears (RCTs). These tears represent a painful, disabling condition for which there ...
Breaking Biology News(10 mins):
(Date:1/4/2019)... ... January 02, 2019 , ... ... precancer and cancer cells in blood, has been named as a partner in ... biotech company developing cell therapies for cancer treatment, will use CellMax Life’s circulating ...
(Date:12/19/2018)... ... December 19, 2018 , ... ... first rate Stem Cell Training Course in Las Vegas. Training includes facial rejuvenation, ... procedures explode in popularity nationwide for aesthetics, having the training from expert, Board ...
(Date:12/18/2018)... ... December 18, 2018 , ... ... optimization firm for the life sciences industry, unveiled a completely redesigned website at ... a more user-friendly browsing experience for their valued clients and business partners. ...
(Date:12/13/2018)... Mass. (PRWEB) , ... December 11, 2018 , ... ... biosensor that doctors and nurses can use to quickly detect Clostridium difficile (C. ... be the heart of a handheld device that can be used onsite in ...
Breaking Biology Technology:
Cached News: