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Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery

hemobartonella, that adhere to RBCs and can remain in circulation for several weeks.

The researchers say that it may be possible to keep the nanoparticles in circulation for a relatively long time, theoretically up to the circulation lifetime of a red blood cell which is 120 days if the binding between particles and the red blood cells is strengthened. The methodology is applicable to drugs that are effective while still attached to a red blood cell, although the researchers say that slow release from the red blood cell surface is also feasible.

Mitragotri says this mode of prolonging particle circulation has significant implications in drug delivery, potentially leading to new treatments for a broad variety of conditions such as cancer, blood clots and heart disease. Dr. Steven R. Goodman, Editor-in-Chief of the journal, said this study dealing with the attachment of nanoparticles to red blood cells may also have important implications for future treatment of hematologic disorders. This fusion of modern nanobioscience with cell biology and hematology is precisely the type of interdisciplinary study that the new Experimental Biology and Medicine is interested in publishing. Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences.


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Contact: Dr. Samir Mitragotri
samir@engineering.ucsb.edu
805-893-7532
Society for Experimental Biology and Medicine
27-Jun-2007


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