HOME >> BIOLOGY >> NEWS
Nanotech hitchhikers in blood

Santa Barbara, Calif. -- Researchers at the University of California, Santa Barbara have discovered that attaching polymeric nanoparticles to the surface of red blood cells dramatically increases the in vivo lifetime of the nanoparticles. The research, published July 7 in Experimental Biology and Medicine, could offer applications for the delivery of drugs and circulating bioreactors.

Polymeric nanoparticles are excellent carriers for delivering drugs. They protect drugs from degradation until they reach their target and provide sustained release of drugs. Polymeric nanoparticles, however, suffer from one major limitation: they are quickly removed from the blood, sometimes in minutes, rendering them ineffective in delivering drugs.

The research team, led by Samir Mitragotri, a professor of chemical engineering, and Elizabeth Chambers, a recent doctoral graduate, found that nanoparticles can be forced to remain in circulation when attached to red blood cells. The particles eventually detach from the blood cells due to shear forces and cell-to-cell interactions, and are cleared from the system by the liver and spleen. Red blood cell circulation is not affected by attaching the nanoparticles.

Attachment of polymeric nanoparticles to red blood cells combines the advantages of the long circulating lifetime of the red blood cell, and their abundance, with the robustness of polymeric nanoparticles, said Mitragotri. Using red blood cells to extend the circulation time of the particles avoids the need to modify the surface chemistry of the entire particle, which offers the potential to attach chemicals to the exposed surface for targeting applications.

The researchers have learned that particles adhered to red blood cells can escape phagocytosis because red blood cells have a knack for evading macrophages. Nanoparticles arent the first to be piggybacking on red blood cells; the strategy has already been adopted by certain bacteria, s
'"/>

Contact: Barbara B. Gray
bbgray@engineering.ucsb.edu
818-889-5415
University of California - Santa Barbara
27-Jun-2007


Page: 1 2

Related biology news :

1. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
2. FDA Nanotechnology Task Force takes positive step forward
3. A new report, Where Does the Nano Go? End-of-Life Regulation of Nanotechnologies
4. Nanotechnology, medicine and bioethics
5. Nanotechnology: consumers must be convinced benefits outweigh risks
6. Nanotechnology requires immediate changes in EPA
7. Nanotechnology provides green path to environmentally sustainable economy
8. Nanotechnology offers hope for treating spinal cord injuries, diabetes and Parkinsons disease
9. Green Nanotechnology: Its Easier Than You Think
10. Nanotechnologys past, present and future: A Congressional perspective
11. Nanotechnology oversight requires thinking outside the box

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... (PRWEB) , ... July 01, 2020 , ... ... presented its phase 1a findings of Neihulizumab, a biologic for the treatment of ... June 2020. Led by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a ... most common and aggressive adult brain cancer—announced today the appointments of its first ... charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows are ...
(Date:6/25/2020)... ... June 24, 2020 , ... ... software-driven clinical data services that accelerate drug development, is collaborating with Karyopharm Therapeutics ... inhibitor, in hospitalized patients with severe COVID-19. This is the first study of ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... , ... July 06, 2020 , ... ... Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts ... Bio-IT World has hosted an elite awards program, highlighting outstanding examples of how ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... launch of a new clinical diagnostics immuno-oncology service, TissueInsight . TissueInsight ... , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and immunologists ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. (“Lumeda”), ... announced the company has entered a license agreement with Roswell Park Comprehensive Cancer ... exclusive rights to Roswell Park intellectual property surrounding a novel medical device and ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... solutions in complex indoor environments, announced today that Derek Fournier has been appointed ... of Chairman of the Board, effective immediately. , “DeCurtis Corporation has been ...
Breaking Biology Technology:
Cached News: