HOME >> BIOLOGY >> NEWS
Nanotechnology enables low-dose treatment of atherosclerotic plaques

s to cells found in newly developing blood vessels. Stuck in this position, the nanoparticle drops its load of fumagillin, concentrating it at the site of the atherosclerotic plaque.

In this study, the single dosage of fumagillin each rabbit received was 50,000 times lower than the total fumagillin dose used in an earlier experiment by another research group and yet reduced the growth of new blood vessels in plaques by 60 to 80 percent.

"Fumagillin can have neurocognitive side effects, causing injury to the brain at high doses," Winter says. "The ability of the nanoparticles to concentrate the drug at the disease site allows the dose to be lowered. This could open the door for a lot of drugs that have failed to be approved because they caused too many side effects at a higher dose. It might pay to look at these drugs again and ask if placing them on these nanoparticles can help them be effective at a lower dose and clinically useful."

The nanoparticles are the invention of Samuel Wickline, M.D., professor of medicine, of biomedical engineering, of physics and of cell biology and physiology, and Gregory Lanza, M.D., Ph.D., associate professor of medicine and biomedical engineering. Both are heart specialists at Barnes-Jewish Hospital.

The microscopic spheres are capable of carrying a variety of components at the same time and can be detected with standard MRI scans, making them useful for imaging disease sites while simultaneously treating them. Using the nanoparticles, a physician can confirm a drug has reached the desired location, measure the amount of drug at the site, and later check to see if the drug has affected the disease.

In the current study, the researchers fed rabbits a high-cholesterol diet for 80 days before treatment with fumagillin nanoparticles. The diet caused numerous small plaques in the rabbits' aortas, but the plaques were considered to be at an early stage of growth. By demonstrating the utility of the nanoparticles
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
27-Jul-2006


Page: 1 2 3

Related biology news :

1. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
2. FDA Nanotechnology Task Force takes positive step forward
3. Nanotechnology, medicine and bioethics
4. Nanotechnology: consumers must be convinced benefits outweigh risks
5. Nanotechnology requires immediate changes in EPA
6. Nanotechnology provides green path to environmentally sustainable economy
7. Nanotechnology offers hope for treating spinal cord injuries, diabetes and Parkinsons disease
8. Green Nanotechnology: Its Easier Than You Think
9. Nanotechnologys past, present and future: A Congressional perspective
10. Nanotechnology oversight requires thinking outside the box
11. Change in webcast time for Wednesday event on NIOSH Nanotechnology Research Center progress report

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... TORONTO (PRWEB) , ... June 04, 2019 , ... ... automate the search for salient features of seizure risk signals, usually based on ... neurologist-driven EEG interpretation remains the only acceptable diagnostic methodology due to the complexity ...
(Date:6/1/2019)... ... May 31, 2019 , ... ... & Rosati recently invested in BioFactura’s $6M Series B Financing Round. , ... value-added institutional investors who bring significant financial and business resources to bear as ...
(Date:5/31/2019)... ... 30, 2019 , ... Join Julie Peacock, Vice President of ... Wednesday, June 19, 2019 at 1pm EDT where she will demonstrate how role-based ... and contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... (PRWEB) , ... July 02, 2019 , ... Leading Regenerative ... entitled Animal Pharm: Where Beasts Meet Biotech. The film focuses on regenerative veterinary ... animals. Animal Pharm was recently included in the Brentwood and Pacific ...
(Date:6/11/2019)... ... 2019 , ... Thought Technology Ltd is pleased to announce ... Tech Ltd as its authorised distributor for the UK and Ireland. , ... and clinical assessment protocols to treat stress related disorders as well as provide ...
(Date:6/11/2019)... ... June 11, 2019 , ... A ... mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying ... on mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. ...
(Date:5/31/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... May 30, ... ... the future of neurotoxins, is pleased to announce the strategic acquisition of Metabiologics, ... for research. The acquisition provides Object exclusive ownership and commercialization rights to a ...
Breaking Biology Technology:
Cached News: