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Nanotechnology enables low-dose treatment of atherosclerotic plaques

for early intervention of atherosclerosis, the research group hopes that they can help alleviate the need for more invasive treatment of later-stage atherosclerosis.

"We wanted to go after the early stages of the disease when patients don't yet need immediate intervention to prevent serious cardiac problems," Winter says. "We think fumagillin nanoparticles potentially could be incorporated into a protocol that includes lipid-lowering statin drugs or dietary changes." Next, the research group plans to study the effect of fumagillin nanoparticles in the treatment of cancerous tumors. According to Winter, the use of inhibitors of blood vessel growth is a well-accepted therapy for cancer, suggesting the nanotechnology may prove beneficial in cancer therapy.

Winter PM, Neubauer AM, Caruthers SD, Harris TD, Robertson JD, Williams TA, Schmieder AH, Hu G, Allen JS, Lacy EK, Wickline SA, Lanza GM. Endothelial 3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology September 2006, available on line ahead of print.


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Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
27-Jul-2006


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