HOME >> BIOLOGY >> NEWS
National Eye Institute funds search for genetic key to corneal disease

HOUSTON (Nov. 5, 2004) A new federal grant focusing on painful inherited visual disorders that scar the cornea will allow researchers to narrow the genetic cause of one type of corneal dystrophy and to offer improved diagnosis of this family of diseases.

The $1.1 million, three-year award by the National Eye Institute funds follow-up research on Thiel-Behnke Corneal Dystrophy by principal investigators Richard W.Yee, M.D., clinical professor, and Xinping Zhao, Ph.D., assistant professor, both of the Department of Ophthalmology and Visual Science at The University of Texas Medical School at Houston.

"Thiel-Behnke causes spots of varying shape they can look sort of like a fingerprint or be a dense patch blocking out light on the front layer of cells in the cornea," Yee said. "Onset can occur as early as infancy, as late as adolescence, and is accompanied by a sharp, stabbing pain. The spots can be visually debilitating." The cornea is the curved, transparent layer at the very front of the eye.

Yee, Zhao, and UT School of Public Health Human Genetics Center colleagues Stephen Daiger, Ph.D., and Lori Sullivan, Ph.D., previously narrowed the genetic cause of Thiel-Behnke to a short portion of DNA on chromosome 10. The NEI grant will fund an intensive effort to pinpoint the culprit variation among possible genes on that strip of the chromosome, clarifying the molecular cause of the disease.

Once treatable only by corneal transplantation, Thiel-Behnke is now treated by laser surgery but can still result in loss of vision, Yee said.

In addition to understanding the origins of Thiel-Behnke, Yee anticipates that the grant will allow his team to help diagnose other varieties of corneal dystrophy.

"There are many types of dystrophy and it's difficult to discern them just by looking at them," Yee said. "Physicians will be able to send us blood samples of patients, which we can screen for known mutations using genetic markers -- not just for
'"/>

Contact: Scott Merville
scott.merville@uth.tmc.edu
713-500-3042
University of Texas Health Science Center at Houston
5-Nov-2004


Page: 1 2

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, August 2007
2. National Ecological Observatory Network featured at ESA/SER Joint International Conference
3. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
4. Bumblebees make bee line for gardens, National Bumblebee Nest Survey finds
5. Elsevier partners with National Natural Science Foundation of China
6. President Bush announces 2005 and 2006 Laureates of National Medals of Science and Technology
7. Fedoroff, of Penn State, to receive National Medal of Science
8. Story tips from the Department of Energys Oak Ridge National Laboratory
9. Los Alamos National Laboratory making progress in Groundwater Protection Program
10. Candidate research sites selected for the National Ecological Observatory Network
11. Computer science professor awarded $400,000 from National Science Foundation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: National Eye Institute funds search for genetic key corneal disease

(Date:10/16/2014)... Virginia Institute of Marine Science have received a ... to identify the streams and wetlands most vulnerable ... help local governments and citizens conserve these important ... dataset of tidal-marsh observations first gathered by VIMS ... baseline can today,s researchers accurately map the slow ...
(Date:10/16/2014)... have challenged conventional thinking on how the bowel lining ... for how bowel cancer starts. , The researchers produced ... regenerating the ,crypts, that are a feature of the ... in bowel cancer development, a controversial finding as scientists ... Using 3D imaging technologies, Dr Chin Wee Tan and ...
(Date:10/16/2014)... Virus causes severe respiratory tract infections and worldwide ... Scientists at VIB and Ghent University have succeeded ... this common virus infection. , Xavier Saelens ... paves the way for the development of a ... that causes suffering in numerous small children and ...
Breaking Biology News(10 mins):EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2New perspectives for development of an RSV vaccine 2
(Date:10/22/2014)... Md. (PRWEB) October 21, 2014 Shimadzu ... an LC/MS/MS data tool for the pain management and ... of data processing and review by allowing users to ... to clinicians. , QuantAnalytics allows analysts to filter ... This expedites data processing by eliminating the need to ...
(Date:10/22/2014)... Currently offering a comprehensive portfolio ... Weighing, Rice Lake, and Ohaus, Pipette.com has added ... Sartorius CPA Semi-Micro Balance is ideal for lab ... user-friendly laboratory balance. , Sartorius is a global ... balances are well known for their high performance, ...
(Date:10/22/2014)... According to new market research report "Cloud ... Deployment & Support), by Service Model (SaaS, PaaS, ... (Hybrid & Community)) - Global Forecast to 2019", ... Professional Services Market into various sub-segments with an ... identifies the drivers and restraints for this market ...
(Date:10/22/2014)... YORK , Oct. 22, 2014 Nuvilex, ... Federation, approximately 400 million people worldwide are living with ... million people by 2030.  The global market for diabetes ... 2012 approximately 330,000 people worldwide died from pancreatic cancer.  ... death due to cancer in the United ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2
Cached News: