HOME >> BIOLOGY >> NEWS
National Eye Institute funds search for genetic key to corneal disease

HOUSTON (Nov. 5, 2004) A new federal grant focusing on painful inherited visual disorders that scar the cornea will allow researchers to narrow the genetic cause of one type of corneal dystrophy and to offer improved diagnosis of this family of diseases.

The $1.1 million, three-year award by the National Eye Institute funds follow-up research on Thiel-Behnke Corneal Dystrophy by principal investigators Richard W.Yee, M.D., clinical professor, and Xinping Zhao, Ph.D., assistant professor, both of the Department of Ophthalmology and Visual Science at The University of Texas Medical School at Houston.

"Thiel-Behnke causes spots of varying shape they can look sort of like a fingerprint or be a dense patch blocking out light on the front layer of cells in the cornea," Yee said. "Onset can occur as early as infancy, as late as adolescence, and is accompanied by a sharp, stabbing pain. The spots can be visually debilitating." The cornea is the curved, transparent layer at the very front of the eye.

Yee, Zhao, and UT School of Public Health Human Genetics Center colleagues Stephen Daiger, Ph.D., and Lori Sullivan, Ph.D., previously narrowed the genetic cause of Thiel-Behnke to a short portion of DNA on chromosome 10. The NEI grant will fund an intensive effort to pinpoint the culprit variation among possible genes on that strip of the chromosome, clarifying the molecular cause of the disease.

Once treatable only by corneal transplantation, Thiel-Behnke is now treated by laser surgery but can still result in loss of vision, Yee said.

In addition to understanding the origins of Thiel-Behnke, Yee anticipates that the grant will allow his team to help diagnose other varieties of corneal dystrophy.

"There are many types of dystrophy and it's difficult to discern them just by looking at them," Yee said. "Physicians will be able to send us blood samples of patients, which we can screen for known mutations using genetic markers -- not just for
'"/>

Contact: Scott Merville
scott.merville@uth.tmc.edu
713-500-3042
University of Texas Health Science Center at Houston
5-Nov-2004


Page: 1 2

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, August 2007
2. National Ecological Observatory Network featured at ESA/SER Joint International Conference
3. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
4. Bumblebees make bee line for gardens, National Bumblebee Nest Survey finds
5. Elsevier partners with National Natural Science Foundation of China
6. President Bush announces 2005 and 2006 Laureates of National Medals of Science and Technology
7. Fedoroff, of Penn State, to receive National Medal of Science
8. Story tips from the Department of Energys Oak Ridge National Laboratory
9. Los Alamos National Laboratory making progress in Groundwater Protection Program
10. Candidate research sites selected for the National Ecological Observatory Network
11. Computer science professor awarded $400,000 from National Science Foundation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... public,s help is being enlisted in what,s thought to be the biggest ... human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date ... project's goal is to help advance scientific knowledge of the role of ... The ...
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
(Date:10/11/2017)... ... ... a basic first aid supply for any work environment, but most personal eye wash can ... a dangerous substance enters both eyes? It’s one less decision, and likely quicker response time ... , “Whether its dirt and debris, or an acid or alkali, getting anything in your ...
(Date:10/11/2017)... BioMarketing, a leading provider of patient support solutions, has announced ... network, which will launch this week. The VMS CNEs will ... to enhance the patient care experience by delivering peer-to-peer education ... professionals to help women who have been diagnosed and are ... ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
Breaking Biology Technology:
Cached News: