HOME >> BIOLOGY >> NEWS
National Eye Institute funds search for genetic key to corneal disease

HOUSTON (Nov. 5, 2004) A new federal grant focusing on painful inherited visual disorders that scar the cornea will allow researchers to narrow the genetic cause of one type of corneal dystrophy and to offer improved diagnosis of this family of diseases.

The $1.1 million, three-year award by the National Eye Institute funds follow-up research on Thiel-Behnke Corneal Dystrophy by principal investigators Richard W.Yee, M.D., clinical professor, and Xinping Zhao, Ph.D., assistant professor, both of the Department of Ophthalmology and Visual Science at The University of Texas Medical School at Houston.

"Thiel-Behnke causes spots of varying shape they can look sort of like a fingerprint or be a dense patch blocking out light on the front layer of cells in the cornea," Yee said. "Onset can occur as early as infancy, as late as adolescence, and is accompanied by a sharp, stabbing pain. The spots can be visually debilitating." The cornea is the curved, transparent layer at the very front of the eye.

Yee, Zhao, and UT School of Public Health Human Genetics Center colleagues Stephen Daiger, Ph.D., and Lori Sullivan, Ph.D., previously narrowed the genetic cause of Thiel-Behnke to a short portion of DNA on chromosome 10. The NEI grant will fund an intensive effort to pinpoint the culprit variation among possible genes on that strip of the chromosome, clarifying the molecular cause of the disease.

Once treatable only by corneal transplantation, Thiel-Behnke is now treated by laser surgery but can still result in loss of vision, Yee said.

In addition to understanding the origins of Thiel-Behnke, Yee anticipates that the grant will allow his team to help diagnose other varieties of corneal dystrophy.

"There are many types of dystrophy and it's difficult to discern them just by looking at them," Yee said. "Physicians will be able to send us blood samples of patients, which we can screen for known mutations using genetic markers -- not just for
'"/>

Contact: Scott Merville
scott.merville@uth.tmc.edu
713-500-3042
University of Texas Health Science Center at Houston
5-Nov-2004


Page: 1 2

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, August 2007
2. National Ecological Observatory Network featured at ESA/SER Joint International Conference
3. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
4. Bumblebees make bee line for gardens, National Bumblebee Nest Survey finds
5. Elsevier partners with National Natural Science Foundation of China
6. President Bush announces 2005 and 2006 Laureates of National Medals of Science and Technology
7. Fedoroff, of Penn State, to receive National Medal of Science
8. Story tips from the Department of Energys Oak Ridge National Laboratory
9. Los Alamos National Laboratory making progress in Groundwater Protection Program
10. Candidate research sites selected for the National Ecological Observatory Network
11. Computer science professor awarded $400,000 from National Science Foundation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
(Date:6/9/2016)... 2016  Perkotek an innovation leader in attendance control systems is proud to announce ... for employers to make sure the right employees are actually signing in, and to ... ... ... ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 Andrew D ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
(Date:6/22/2016)... , June 22, 2016   StockNewsNow.com , ... Video Interview with Dr. Nader Pourhassan , President ... company focused on the clinical development and potential commercialization ... of HIV infection, according to the company,s website (see ... on Tuesday, June 7 th , 2016, at the ...
(Date:6/22/2016)... DIEGO , June 22, 2016  Mesa ... has developed a testing platform designed specifically for ... formation of their scientific advisory board (SAB). Approved ... directors, the SAB is chartered to advise on ... disease assay platform. Led by Dr. Steve ...
Breaking Biology Technology:
Cached News: