HOME >> BIOLOGY >> NEWS
Natural antibiotics yield secrets to atom-level imaging technique

ANN ARBOR, Mich. -- Frog skin and human lungs hold secrets to developing new antibiotics, and a technique called solid-state NMR spectroscopy is a key to unlocking those secrets.

That's the view of University of Michigan researcher Ayyalusamy Ramamoorthy, who will discuss his group's progress toward that goal March 3 at the annual meeting of the Biophysical Society in Baltimore, Md.

Ramamoorthy's research group is using solid-state NMR to explore the germ-killing properties of natural antibiotics called antimicrobial peptides (AMPs), which are produced by virtually all animals, from insects to frogs to humans. AMPs are the immune system's early line of defense, battling microbes at the first places they try to penetrate: skin, mucous membranes and other surfaces. They're copiously produced in injured or infected frog skin, for instance, and the linings of the human respiratory and gastrointestinal tracts also crank out the short proteins in response to invading pathogens.

In addition to fighting bacteria, AMPs attack viruses, fungi and even cancer cells, so drugs designed to mimic them could have widespread medical applications, said Ramamoorthy, who is an associate professor of chemistry and an associate research scientist in the Biophysics Research Division.

While researchers have identified hundreds of AMPs in recent years, they're still puzzling over exactly how the peptides wipe out bacteria and other microbes. Unlike conventional antibiotics, which typically inhibit specific bacterial proteins, AMPs get downright physical with invaders, punching holes into their membranes. But they're selectively pugnacious, targeting microbes but leaving healthy host cells alone.

"They're like smart bombs," Ramamoorthy said. "We'd like to exploit their properties to design super-smart bombs, but before we can do that, we need to understand how these AMP smart bombs interact with membranes to destroy bacteria. We need to kn
'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
3-Mar-2007


Page: 1 2 3

Related biology news :

1. Elsevier partners with National Natural Science Foundation of China
2. Natural compound and exercise boost memory in mice
3. Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
4. Natural anti-freeze -- how arthropods survive the cold
5. Natural mechanism for immune suppression paves way for cancer trials
6. Natural polyester makes new sutures stronger, safer
7. Natural fiber may take extra pounds away
8. Natural gut hormone offers hope for new obesity drug
9. Naturally occurring enzyme can break down key part of Alzheimers plaques
10. Natural anti-viral enzyme helps keep cancer cells alive, researchers find
11. Natural resources and the economy: hand in hand

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... August 28, 2019 , ... Lajollacooks4u has expanded its team as it gears ... events company has seen record growth in 2019, having hosted a multitude of team-building ... Illumina, have all visited the company’s La Jolla-based venue, and Lajollacooks4u has worked hard ...
(Date:8/27/2019)... ... August 27, 2019 , ... Advancements with Ted Danson ... is scheduled to broadcast 4Q/2019. Check local listings for more information. , ... manufacturing company. The show will highlight how Debiopharm is working to champion the ...
(Date:8/21/2019)... (PRWEB) , ... August 20, 2019 , ... ... development and commercialization of bioactive technologies for the spine, today announced the 510(K) ... features a unique surface modification that is proven to improve osseointegration through superior ...
Breaking Biology News(10 mins):
(Date:8/29/2019)... ... 28, 2019 , ... DuPont Nutrition & Biosciences will offer ... the International Baking Industry Expo, September 8 to 11, in booth 5015. DuPont ... cost and waste reduction and from maintaining freshness throughout shelf life to reformulating ...
(Date:8/23/2019)... Wis. (PRWEB) , ... August 22, 2019 , ... The ... some of the most harmful germs and pathogens on hard surfaces including E. Coli, ... leaves behind no chemical residues. For more information, visit the product page at rovingblue.com ...
(Date:8/8/2019)... FRANCISCO (PRWEB) , ... August 08, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced that the ... Value Leadership Award for the IVA market . Inference will officially accept the ...
(Date:8/6/2019)... ... August 06, 2019 , ... The National Science Foundation ... a community project that will engage middle and early high school students in ... Youth-Led Citizen Science Network for Community Environmental Assessment.” Collaborative partners presenting the authentic ...
Breaking Biology Technology:
Cached News: