HOME >> BIOLOGY >> NEWS
Natural antibiotics yield secrets to atom-level imaging technique

ANN ARBOR, Mich. -- Frog skin and human lungs hold secrets to developing new antibiotics, and a technique called solid-state NMR spectroscopy is a key to unlocking those secrets.

That's the view of University of Michigan researcher Ayyalusamy Ramamoorthy, who will discuss his group's progress toward that goal March 3 at the annual meeting of the Biophysical Society in Baltimore, Md.

Ramamoorthy's research group is using solid-state NMR to explore the germ-killing properties of natural antibiotics called antimicrobial peptides (AMPs), which are produced by virtually all animals, from insects to frogs to humans. AMPs are the immune system's early line of defense, battling microbes at the first places they try to penetrate: skin, mucous membranes and other surfaces. They're copiously produced in injured or infected frog skin, for instance, and the linings of the human respiratory and gastrointestinal tracts also crank out the short proteins in response to invading pathogens.

In addition to fighting bacteria, AMPs attack viruses, fungi and even cancer cells, so drugs designed to mimic them could have widespread medical applications, said Ramamoorthy, who is an associate professor of chemistry and an associate research scientist in the Biophysics Research Division.

While researchers have identified hundreds of AMPs in recent years, they're still puzzling over exactly how the peptides wipe out bacteria and other microbes. Unlike conventional antibiotics, which typically inhibit specific bacterial proteins, AMPs get downright physical with invaders, punching holes into their membranes. But they're selectively pugnacious, targeting microbes but leaving healthy host cells alone.

"They're like smart bombs," Ramamoorthy said. "We'd like to exploit their properties to design super-smart bombs, but before we can do that, we need to understand how these AMP smart bombs interact with membranes to destroy bacteria. We need to kn
'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
3-Mar-2007


Page: 1 2 3

Related biology news :

1. Elsevier partners with National Natural Science Foundation of China
2. Natural compound and exercise boost memory in mice
3. Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
4. Natural anti-freeze -- how arthropods survive the cold
5. Natural mechanism for immune suppression paves way for cancer trials
6. Natural polyester makes new sutures stronger, safer
7. Natural fiber may take extra pounds away
8. Natural gut hormone offers hope for new obesity drug
9. Naturally occurring enzyme can break down key part of Alzheimers plaques
10. Natural anti-viral enzyme helps keep cancer cells alive, researchers find
11. Natural resources and the economy: hand in hand

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... ... 2020 , ... Join experts from Envigo Lauren Klaskala, Project Manager ... webinar on Wednesday, July 8, 2020 at 11am EDT (4pm BST/UK). , Nuclease-based ... models. However, while modifying the genome may be more straightforward, the challenge to create ...
(Date:6/11/2020)... Fla. (PRWEB) , ... June 08, 2020 , ... ... demand for masks and other protective measures to protect workers in the medical ... and their dedicated staffs who valiantly risk their lives every day to provide ...
(Date:6/5/2020)... ... June 04, 2020 , ... Murrieta Genomics has ... patent application for simplified sample preparation for Next Generation Genomic Sequencing (NGS) . ... cost, time, and complexity of sample preparation. , “I have been at the bench ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... ... therapies, today announced that it has filed an Investigational New Drug application (IND) ... clinical trial of its lead drug candidate NBTX-001 in patients with panic disorder ...
(Date:6/11/2020)... Md. (PRWEB) , ... June 09, 2020 , ... ... today the release of the NEON Micro-Tracer Solution, a highly accurate, ... the COVID-19 virus in the workplace. Contact tracing, a core disease control measure, ...
(Date:5/30/2020)... ... May 29, 2020 , ... Medrio, Inc., the ... health markets, has enabled Cytovale, Inc., a medical technology company dedicated to revolutionizing ... achieve their first patient in (FPI) in just seven days. The Cytovale technology ...
(Date:5/26/2020)... MENLO PARK, Calif. (PRWEB) , ... May 26, 2020 , ... ... Genie , the most recognized brand of smart garage door openers, announce a new ... full line of Wi-Fi enabled garage door openers powered by Aladdin Connect® can now ...
Breaking Biology Technology:
Cached News: