HOME >> BIOLOGY >> NEWS
Natural antibiotics yield secrets to atom-level imaging technique

ANN ARBOR, Mich. -- Frog skin and human lungs hold secrets to developing new antibiotics, and a technique called solid-state NMR spectroscopy is a key to unlocking those secrets.

That's the view of University of Michigan researcher Ayyalusamy Ramamoorthy, who will discuss his group's progress toward that goal March 3 at the annual meeting of the Biophysical Society in Baltimore, Md.

Ramamoorthy's research group is using solid-state NMR to explore the germ-killing properties of natural antibiotics called antimicrobial peptides (AMPs), which are produced by virtually all animals, from insects to frogs to humans. AMPs are the immune system's early line of defense, battling microbes at the first places they try to penetrate: skin, mucous membranes and other surfaces. They're copiously produced in injured or infected frog skin, for instance, and the linings of the human respiratory and gastrointestinal tracts also crank out the short proteins in response to invading pathogens.

In addition to fighting bacteria, AMPs attack viruses, fungi and even cancer cells, so drugs designed to mimic them could have widespread medical applications, said Ramamoorthy, who is an associate professor of chemistry and an associate research scientist in the Biophysics Research Division.

While researchers have identified hundreds of AMPs in recent years, they're still puzzling over exactly how the peptides wipe out bacteria and other microbes. Unlike conventional antibiotics, which typically inhibit specific bacterial proteins, AMPs get downright physical with invaders, punching holes into their membranes. But they're selectively pugnacious, targeting microbes but leaving healthy host cells alone.

"They're like smart bombs," Ramamoorthy said. "We'd like to exploit their properties to design super-smart bombs, but before we can do that, we need to understand how these AMP smart bombs interact with membranes to destroy bacteria. We need to kn
'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
3-Mar-2007


Page: 1 2 3

Related biology news :

1. Elsevier partners with National Natural Science Foundation of China
2. Natural compound and exercise boost memory in mice
3. Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
4. Natural anti-freeze -- how arthropods survive the cold
5. Natural mechanism for immune suppression paves way for cancer trials
6. Natural polyester makes new sutures stronger, safer
7. Natural fiber may take extra pounds away
8. Natural gut hormone offers hope for new obesity drug
9. Naturally occurring enzyme can break down key part of Alzheimers plaques
10. Natural anti-viral enzyme helps keep cancer cells alive, researchers find
11. Natural resources and the economy: hand in hand

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2019)... ... January 16, 2019 , ... uBiome, the leader in ... that uses artificial intelligence (AI) and a data-centric approach to decentralize medicine using ... colitis. , People will Crohn’s or other chronic medical conditions join a relevant ...
(Date:1/14/2019)... ... 14, 2019 , ... CellMax Life , a diagnostics ... will present new findings at the ASCO Gastrointestinal Cancer Symposium in San Francisco ... from this study show CellMax Life’s blood test, based on its proprietary CMxTM ...
(Date:1/10/2019)... ... 2019 , ... A major goal for pharmaceutical companies has ... significantly more expensive in vivo studies in order to reduce costs and improve ... researchers have begun to adopt 3D cell culture models which have been shown ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 30, 2019 , ... In ... tasting 5StarWines to promote and give recognition to producers whose work focuses entirely ... selection takes place in Verona, Italy, contemporaneously to the 5StarWines blind tasting organized ...
(Date:1/24/2019)... ... 22, 2019 , ... Controlled Contamination Services is pleased to announce three exciting ... these valuable new team members will support its growing operation across the US and ... scales its business. This addition will enable CCS to widen its reach and provide ...
(Date:1/24/2019)... ... January 22, 2019 , ... Outsourcing trials to contract ... of assumptions, and RFP creation and management generally requires manual effort. Additionally, each ... to oranges. These challenges can ultimately lead to study start delays and change ...
(Date:1/21/2019)... FRANKLIN, Wis. (PRWEB) , ... January 21, 2019 ... ... company, announced their newest product line, SporActiv™, for the industrial and institutional cleaning ... a variety of residential and commercial cleaning needs. Applications include odor control, floor ...
Breaking Biology Technology:
Cached News: