HOME >> BIOLOGY >> NEWS
Natural mechanism for immune suppression paves way for cancer trials

A natural mechanism pirated by tumors and HIV to evade the immune response is opening the door to better treatment for these conditions, researchers say.

The National Cancer Institute and Iowa biopharmaceutical company NewLink Genetics are pursuing FDA approval to move forward with cancer trials of a drug that inhibits the mechanism, an enzyme called indoleomine 2, 3-dioxegenase, or IDO, says Dr. Andrew Mellor, director of the Immunotherapy Center at the Medical College of Georgia.

The Georgia Research Alliance Eminent Scholar in Immunogenetics will deliver seminars about the biology and immunology of the mechanism at the Keystone Symposium on The Potent New Anti-Tumor Immunotherapies, in Alberta, Canada, March 28-April 2 and the World Immune Regulation Meeting April 10-16 in Switzerland.

Immune cells, particularly those in the mucosal surfaces of the gut, lungs and eyes, express IDO to mediate inflammation triggered by the constant assault of substances from outside the body.

Now, scientists know cancer in humans and mice also attract cells that express IDO, which degrades tryptophan, an amino acid essential to survival of immune system orchestrators called T-cells. MCG researchers are still exploring how IDO interacts with other cells to amplify immune suppression.

A team of MCG scientists, led by Dr. Mellor and his colleague, MCG pediatric oncologist Dr. David Munn, showed in 1998 that the fetus also expresses IDO to help avoid rejection by the mothers immune system. When they used an orphan drug known to suppress IDO in pregnant laboratory mice, fetuses were rejected.

The findings, published in Science, led the scientists to suspect and later prove that tumors and some viruses, including HIV, express it as well.

"Cancers should evoke a response from the immune system and dont," says Dr. Mellor. "That is a big question in the immunology field: Why dont they?"'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
28-Mar-2007


Page: 1 2 3

Related biology news :

1. Elsevier partners with National Natural Science Foundation of China
2. Natural compound and exercise boost memory in mice
3. Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
4. Natural anti-freeze -- how arthropods survive the cold
5. Natural polyester makes new sutures stronger, safer
6. Natural antibiotics yield secrets to atom-level imaging technique
7. Natural fiber may take extra pounds away
8. Natural gut hormone offers hope for new obesity drug
9. Naturally occurring enzyme can break down key part of Alzheimers plaques
10. Natural anti-viral enzyme helps keep cancer cells alive, researchers find
11. Natural resources and the economy: hand in hand

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled ... accelerated Point of Care Testing solutions (POCT). Check local listings for more info. , ... medical offices and are shipped to labs throughout the country. Results are then available ...
(Date:6/23/2020)... England (PRWEB) , ... June 23, 2020 , ... ... Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of ... project to support testing operations in the fight against the COVID-19 pandemic in ...
(Date:6/23/2020)... ... ... In its June 22 online post, business and technology news platform Superb Crew reported ... director of stem cell biotechnology company Asymmetrex . Superb Crew decided to highlight ... it would begin offering free tissue stem cell counting at its company ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a leading ... despite many obstacles created as a result of COVID-19. As a provider at ... medical practices and medical manufacturers by expanding access to device offerings, technology services, ...
(Date:6/28/2020)... , ... June 25, 2020 , ... ... advance photodynamic therapy for treating cancer, today announced the company has entered a ... Park”). The agreement provides Lumeda globally exclusive rights to Roswell Park intellectual ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals ... be presented June 22-24 during the American Association for Cancer Research Virtual meeting. ... profiles the potent, consistent single agent activity in KEAP1 mutant tumor models of ...
(Date:6/11/2020)... , ... June 09, 2020 , ... ... release of the NEON Micro-Tracer Solution, a highly accurate, contact tracing ... virus in the workplace. Contact tracing, a core disease control measure, is a ...
Breaking Biology Technology:
Cached News: