HOME >> BIOLOGY >> NEWS
Natural mechanism for immune suppression paves way for cancer trials

A natural mechanism pirated by tumors and HIV to evade the immune response is opening the door to better treatment for these conditions, researchers say.

The National Cancer Institute and Iowa biopharmaceutical company NewLink Genetics are pursuing FDA approval to move forward with cancer trials of a drug that inhibits the mechanism, an enzyme called indoleomine 2, 3-dioxegenase, or IDO, says Dr. Andrew Mellor, director of the Immunotherapy Center at the Medical College of Georgia.

The Georgia Research Alliance Eminent Scholar in Immunogenetics will deliver seminars about the biology and immunology of the mechanism at the Keystone Symposium on The Potent New Anti-Tumor Immunotherapies, in Alberta, Canada, March 28-April 2 and the World Immune Regulation Meeting April 10-16 in Switzerland.

Immune cells, particularly those in the mucosal surfaces of the gut, lungs and eyes, express IDO to mediate inflammation triggered by the constant assault of substances from outside the body.

Now, scientists know cancer in humans and mice also attract cells that express IDO, which degrades tryptophan, an amino acid essential to survival of immune system orchestrators called T-cells. MCG researchers are still exploring how IDO interacts with other cells to amplify immune suppression.

A team of MCG scientists, led by Dr. Mellor and his colleague, MCG pediatric oncologist Dr. David Munn, showed in 1998 that the fetus also expresses IDO to help avoid rejection by the mothers immune system. When they used an orphan drug known to suppress IDO in pregnant laboratory mice, fetuses were rejected.

The findings, published in Science, led the scientists to suspect and later prove that tumors and some viruses, including HIV, express it as well.

"Cancers should evoke a response from the immune system and dont," says Dr. Mellor. "That is a big question in the immunology field: Why dont they?"'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
28-Mar-2007


Page: 1 2 3

Related biology news :

1. Elsevier partners with National Natural Science Foundation of China
2. Natural compound and exercise boost memory in mice
3. Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
4. Natural anti-freeze -- how arthropods survive the cold
5. Natural polyester makes new sutures stronger, safer
6. Natural antibiotics yield secrets to atom-level imaging technique
7. Natural fiber may take extra pounds away
8. Natural gut hormone offers hope for new obesity drug
9. Naturally occurring enzyme can break down key part of Alzheimers plaques
10. Natural anti-viral enzyme helps keep cancer cells alive, researchers find
11. Natural resources and the economy: hand in hand

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... ... , ... USDM Life Sciences (USDM) announces that Jay Crowley, Vice President of ... a Sustainable Global UDI Compliance Strategy at the European UDI Forum on 25 April ... What device manufacturers did to comply with the US FDA UDI rule and should ...
(Date:4/16/2019)... ... 2019 , ... The Healthcare Technology Report is pleased to ... process was run to evaluate the hundreds of CEOs that lead exemplary organizations ... related areas. We gathered data on each nominee’s professional background and assessed them ...
(Date:4/12/2019)... (PRWEB) , ... April 11, 2019 , ... ... is excited to announce their efforts to help decrease opioid abuse by offering ... no charge or a discounted rate, up to 50% off. , In 2019, ...
Breaking Biology News(10 mins):
(Date:4/12/2019)... ... April 12, 2019 , ... An upcoming ... will educate about innovative tools and devices being used to enhance cognitive skills. ... information. , This segment of Advancements will focus on Sound for Life, a ...
(Date:4/9/2019)... Calif. (PRWEB) , ... April 09, 2019 , ... ... services firm focused on increasing the capacity of life sciences organizations to accelerate ... Cloud Assurance platform in the past 12 months. , USDM’s ...
(Date:4/8/2019)... ... April 08, 2019 , ... ... solutions, announced today the launch of their app integration solution, CT Cloud Unite. ... and contact-orientated applications while using CT Cloud Voice and Skype for Business solutions. ...
(Date:4/4/2019)... ... April 02, 2019 , ... ... it would be releasing it’s latest field-ready solution for performing PCR, RT-PCR, qPCR, ... thermocycler Franklin™ pays homage to Rosland Franklin, an English chemist and X-ray crystallographer ...
Breaking Biology Technology:
Cached News: