HOME >> BIOLOGY >> NEWS
Navigating an integrated yeast network

Scientists have for the first time mapped multiple complex biological interactions in a yeast cell in a simple graphical form, enhancing our understanding of how the networks of interaction by which components of a cell influence one another. New research published in the Open Access journal Journal of Biology shows that such maps can also reveal cryptic interactions and enable accurate predictions about interactions that haven't been observed experimentally.

A living cell contains thousands of proteins, genes and macromolecules, enmeshed in complex webs of relationships involving direct or indirect contact. At the simplest level, some recurring patterns of interconnections occur more frequently than expected in randomized networks, and these are called 'network motifs'. Lan Zhang from Harvard Medical School, USA, and colleagues found that the concept of 'network themes' recurring complex patterns that encompass multiple occurrences of network motifs allows the building of 'thematic maps' of interactions between macromolecules that can be tied to biological phenomena and may help represent more fundamental network design principles than do simple motifs.

Zhang et al. integrated five different types of biological relationships found in the yeast Saccharomyces cerevisae: protein-protein interactions, genetic interactions, transcriptional regulation, sequence homology and expression correlation. The authors are the first to integrate so many types of data to search for network motifs. The authors conclude that most network motifs found in the integrated S. cerevisae network can be understood in terms of just a few network themes, associated with specific biological phenomena.

Their results also show that thematic maps can highlight previously unknown relationships between functional modules in a cell. In addition, they can be used to predict interactions that are hard to identify experimentally, or to predict the function of genes involved
'"/>

Contact: Juliette Savin
juliette@biomedcentral.com
44-0-207-631-9931
BioMed Central
31-May-2005


Page: 1 2

Related biology news :

1. Navigating the brain for sense of direction as paradigm for higher cognitive functions
2. $9 million EPSCoR grant to foster integrated research
3. Scientists test the potential of integrated PET/CT for molecular imaging of the heart
4. Tiny tweezers and yeast help St. Jude show how cancer drug works
5. Hives ferment a yeasty brew, attract beetle pest
6. Vitamin extends life in yeast, Dartmouth Medical School researchers find
7. Protein structures for the entire yeast proteome
8. Primitive yeast yields secrets of human cholesterol and drug metabolism
9. MIT: Engineered yeast speeds ethanol production
10. Engineered yeast speeds ethanol production
11. From a lowly yeast, researchers divine a clue to human disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, ... ... ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed for ... complexity. Named in honor of pioneering researcher Rosalind Franklin, who made a ...
(Date:10/11/2017)... Palo Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... is set to take place on 7th and 8th June 2018 in San Francisco, ... and policy influencers as well as several distinguished CEOs, board directors and government officials ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
Breaking Biology Technology:
Cached News: