HOME >> BIOLOGY >> NEWS
Need oxygen? Cells know how to spend and save

in hypoxia. In low oxygen, liver, uterus, lung and colon cells all made COX4-2. The researchers then exposed mice to hypoxia for a few weeks and found that they too showed increased levels of COX4-2.

In 1992, Semenza's team had discovered a protein which they called HIF-1 (for hypoxia-inducible factor 1) that cells make in response to hypoxia. HIF-1 turns on genes that help cells survive when oxygen is low, such as during a heart attack or stroke. The researchers set out to figure out if the sensor protein HIF-1 triggers the COX-swapping.

By examining the gene control regions of COX4, they found that the HIF-1 sensor switched on COX4-2 activity when oxygen is low. And they learned that because COX4-1 already is in the mitochondria, the swap for COX4-2 occurs when the sensor turns on yet another gene that produces an enzyme to specifically chew up COX4-1. Engineering human cells to lack this enzyme and subjecting them to low oxygen, the scientists found the cells unable to rid themselves of COX4-1.

"It's remarkable that the one-celled yeast also swap COX subunits in response to hypoxia, but because they lack HIF-1, they accomplish the swap in a completely different way," says Semenza. "This suggests that adapting mitochondria to changes in oxygen levels may be a major challenge for most organisms on Earth."


'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
5-Apr-2007


Page: 1 2

Related biology news :

1. Cells take risks with their identities
2. Cells re-energize to come back from the brink of death
3. Cells selectively absorb short nanotubes
4. Cells use noise to make cell-fate decisions
5. Cells in the lung clear the air to prevent lung damage
6. Cells passed from mother to child during pregnancy live on and make insulin
7. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
8. Cells use mix-and-match approach to tailor regulation of genes
9. Cells in mucus from lungs of high-risk patients can predict tumor development
10. Double-trouble: Cells with duplicate genomes can trigger tumors
11. Double trouble: Cells with duplicate genomes can trigger tumors

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Need oxygen Cells know how spend and save

(Date:7/29/2014)... science, Clment Vidal takes on big philosophical questions in ... our universe have a beginning and an end, or ... What is the role of intelligent life, if any, ... philosophical rigor, the book presents an evolutionary worldview where ... but may well be the key to unlocking the ...
(Date:7/29/2014)... Northern Territories in Canada and have sent smoke drifting ... on. NASA,s Aqua satellite collected this natural-color image ... July 26, 2014. Actively burning areas, detected by MODIS,s ... smoke are drifting northward in this image. Smoke ... Fire has caused power outages in the area and ...
(Date:7/29/2014)... of Dentistry (UM SOD) and Medicine (UM SOM) ... five-year $10.7 million grant award from the National ... the National Institutes of Health to study the ... The grant, which renews a previous $12 million ... for the research by studying chlamydial and gonorrheal ...
Breaking Biology News(10 mins):Book: 'The Beginning and the End' 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4
(Date:7/29/2014)... team of researchers has created a new way ... textures. These surfaces, made by self-assembly of carbon ... including controllable mechanical stiffness and strength, or ... direction. , "We have demonstrated that mechanical forces ... complex three-dimensional microstructures, and that we can independently ...
(Date:7/29/2014)... biofuels are a viable solution to the dilemma of climate ... very cheap, this is affecting the biofuels market in North ... be in comparison to natural gas. This, in conjunction ... renewable energy developers to get the economics to work and ... companies have shifted their focused within renewable energy. ...
(Date:7/29/2014)... SANTA CLARA, Calif. , July 29, 2014 ... research services agreement with FORMA Therapeutics, Inc., to ... capabilities and proprietary fragment-based lead discovery platform for ... are really excited about the opportunity to work ... the fields of epigenetics and protein homeostasis. FORMA ...
(Date:7/29/2014)... July 29, 2014  ImmunoClin Corporation (IMCL) is ... treatment of infectious diseases as well as nutraceuticals. ... prevention of pathologies like cardiovascular disease, Alzheimer,s disease ... ImmunoClin Corporation will complete the strategic relocation of ... , a key center of North American ...
Breaking Biology Technology:A new way to make microstructured surfaces 2Renewable Waste Intelligence: Could Renewable Chemicals Be the Future for the Renewable Energy Industry? 2Nanosyn Announces Expanded Partnership With FORMA Therapeutics 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3
Cached News: