HOME >> BIOLOGY >> NEWS
Need oxygen? Cells know how to spend and save

in hypoxia. In low oxygen, liver, uterus, lung and colon cells all made COX4-2. The researchers then exposed mice to hypoxia for a few weeks and found that they too showed increased levels of COX4-2.

In 1992, Semenza's team had discovered a protein which they called HIF-1 (for hypoxia-inducible factor 1) that cells make in response to hypoxia. HIF-1 turns on genes that help cells survive when oxygen is low, such as during a heart attack or stroke. The researchers set out to figure out if the sensor protein HIF-1 triggers the COX-swapping.

By examining the gene control regions of COX4, they found that the HIF-1 sensor switched on COX4-2 activity when oxygen is low. And they learned that because COX4-1 already is in the mitochondria, the swap for COX4-2 occurs when the sensor turns on yet another gene that produces an enzyme to specifically chew up COX4-1. Engineering human cells to lack this enzyme and subjecting them to low oxygen, the scientists found the cells unable to rid themselves of COX4-1.

"It's remarkable that the one-celled yeast also swap COX subunits in response to hypoxia, but because they lack HIF-1, they accomplish the swap in a completely different way," says Semenza. "This suggests that adapting mitochondria to changes in oxygen levels may be a major challenge for most organisms on Earth."


'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
5-Apr-2007


Page: 1 2

Related biology news :

1. Cells take risks with their identities
2. Cells re-energize to come back from the brink of death
3. Cells selectively absorb short nanotubes
4. Cells use noise to make cell-fate decisions
5. Cells in the lung clear the air to prevent lung damage
6. Cells passed from mother to child during pregnancy live on and make insulin
7. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
8. Cells use mix-and-match approach to tailor regulation of genes
9. Cells in mucus from lungs of high-risk patients can predict tumor development
10. Double-trouble: Cells with duplicate genomes can trigger tumors
11. Double trouble: Cells with duplicate genomes can trigger tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/21/2016)... Massachusetts , March 22, 2016 ... facial recognition with passcodes for superior security   ... ), a leading provider of secure digital communications services, ... their biometric technology and offer enterprise customers, particularly those ... secure facial recognition and voice authentication within a mobile ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... UTAH. (PRWEB) , ... May 25, 2016 , ... WEDI, ... healthcare information exchange, today announced that Charles W. Stellar has been named by the ... interim CEO since January 2016. As an executive leader with more than 35 years ...
(Date:5/24/2016)... ... ... Last week, Callan Capital, an integrated wealth management firm specializing in asset ... Diego Life Science event at the Estancia La Jolla Resort and Spa. , Over ... Dr. Rich Heyman, former CEO of Aragon and Seragon, and Faheem Hasnain, former CEO ...
(Date:5/23/2016)... England , May 23, 2016 ... May 25 th at 10:15 a.m. ET before the ... the role genetically engineered mosquitos can play in controlling the ... carrier of the Zika virus.      (Logo: ... engineered male mosquito with a self-limiting gene. Trials in ...
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary ... most experienced veterinary clients have treated over 100 of their own patients with the ... provide the highest level of care for their patients. , The veterinarians are ...
Breaking Biology Technology:
Cached News: