Nervous inhibitions

If inhibitory neurons are prevented from carrying out their function, this causes major defects early in embryonal development - and these defects can even occur outside the nervous system. These are the results of a study recently published by scientists from the Max Planck Institute for Experimental Medicine in Göttingen (Neuron, May 18, 2006).

The most common inhibitory transmitters in the mammalian central nervous system are GABA and glycine. Nerve cells can release GABA or glycine where they contact other nerve cells at junctions called synapses. This typically prevents further signal transmission by the post-synaptic cell.

Most inhibitory nerve cells release either GABA or glycine. However, some inhibitory nerve cells appear to be "bilingual", releasing a mixture of GABA and glycine. These mixed-release cells are most common during nervous system development and seem to be crucial for normal spinal cord growth. For brain researchers, however, they have proven mysterious. Most nerve cells specialise in releasing only one type of neurotransmitter. They use transport proteins to pump the neurotransmitter into vesicles surrounded by a membrane and store it there until release is triggered.

Sonja Wojcik and Jeong-Seop Rhee, from the Department of Molecular Neurobiology at the Max Planck Institute for Experimental Medicine in Göttingen, Germany, working with colleagues from Kaiserslautern, Germany and Houston, Texas, have discovered what enables nerve cells to release both GABA and glycine. The researchers discovered that one particular transport protein called VIAAT is able to store both GABA and glycine in vesicles; this joint storage is rather unusual for a classical neurotransmitter. The scientists genetically altered mice so that their nerve cells do not produce VIAAT. This change eliminated both GABA and glycine release.

The scientists did not just solve the problem of simultaneous release of GABA and glycine from "bilingual" sp

Contact: Dr. Sonja M. Wojcik

Page: 1 2

Related biology news :

1. Cooperative science program yields results
2. Delayed treatment of childhood-onset bipolar disorder results in negative outcome in adults
3. Smelling for first time results from knowing abnormalities in congenital loss of smell
4. BDSI announces positive phase III clinical trial results
5. Scientists meet to review Envisat results after 5 years of operations
6. Environment and exercise may affect research results, UA study shows
7. Preliminary results of largest scan of autism DNA information
8. Human trial results show excellent safety data, from Geovaxs DNA/MVA AIDS vaccines
9. Rodent sperm work together for better results
10. Dramatic results from combo therapy surprises Krabb-disease researchers
11. TIGER workshop highlights project results

Post Your Comments:

(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... JOHNSTON, Iowa (PRWEB) , ... October 12, 2017 ... ... company based in Vilnius, Lithuania, announced today that they have entered into a ... collaboration is to provide CRISPR researchers with additional tools for gene editing across ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... (PRWEB) , ... October 12, ... ... ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed for ... complexity. Named in honor of pioneering researcher Rosalind Franklin, who made a ...
(Date:10/11/2017)... ... October 11, 2017 , ... The ... endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. ... is transformative for performing systematic gain-of-function studies. , This complement to loss-of-function ...
Breaking Biology Technology:
Cached News: