HOME >> BIOLOGY >> NEWS
Nervous inhibitions

If inhibitory neurons are prevented from carrying out their function, this causes major defects early in embryonal development - and these defects can even occur outside the nervous system. These are the results of a study recently published by scientists from the Max Planck Institute for Experimental Medicine in Göttingen (Neuron, May 18, 2006).

The most common inhibitory transmitters in the mammalian central nervous system are GABA and glycine. Nerve cells can release GABA or glycine where they contact other nerve cells at junctions called synapses. This typically prevents further signal transmission by the post-synaptic cell.

Most inhibitory nerve cells release either GABA or glycine. However, some inhibitory nerve cells appear to be "bilingual", releasing a mixture of GABA and glycine. These mixed-release cells are most common during nervous system development and seem to be crucial for normal spinal cord growth. For brain researchers, however, they have proven mysterious. Most nerve cells specialise in releasing only one type of neurotransmitter. They use transport proteins to pump the neurotransmitter into vesicles surrounded by a membrane and store it there until release is triggered.

Sonja Wojcik and Jeong-Seop Rhee, from the Department of Molecular Neurobiology at the Max Planck Institute for Experimental Medicine in Göttingen, Germany, working with colleagues from Kaiserslautern, Germany and Houston, Texas, have discovered what enables nerve cells to release both GABA and glycine. The researchers discovered that one particular transport protein called VIAAT is able to store both GABA and glycine in vesicles; this joint storage is rather unusual for a classical neurotransmitter. The scientists genetically altered mice so that their nerve cells do not produce VIAAT. This change eliminated both GABA and glycine release.

The scientists did not just solve the problem of simultaneous release of GABA and glycine from "bilingual" sp
'"/>

Contact: Dr. Sonja M. Wojcik
wojcik@em.mpg.de
49-551-389-9722
Max-Planck-Gesellschaft
29-May-2006


Page: 1 2

Related biology news :

1. Cooperative science program yields results
2. Delayed treatment of childhood-onset bipolar disorder results in negative outcome in adults
3. Smelling for first time results from knowing abnormalities in congenital loss of smell
4. BDSI announces positive phase III clinical trial results
5. Scientists meet to review Envisat results after 5 years of operations
6. Environment and exercise may affect research results, UA study shows
7. Preliminary results of largest scan of autism DNA information
8. Human trial results show excellent safety data, from Geovaxs DNA/MVA AIDS vaccines
9. Rodent sperm work together for better results
10. Dramatic results from combo therapy surprises Krabb-disease researchers
11. TIGER workshop highlights project results

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)...  Data captured by IsoCode, IsoPlexis Corporation,s ... statistically significant association between the potency of ... objective response of cancer patients post-treatment. The ... cancer patients will respond to CAR-T cell ... to improve both pre-infusion potency testing and cell ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... May 17, 2017 , ... ... today that their Chief Executive Officer, Maik Jornitz, was recognized as a Top ... Power List celebrates 100 individuals “involved in bettering the pharma industry and bringing ...
(Date:5/18/2017)... (PRWEB) , ... May 18, 2017 , ... When James Sherley, was notified earlier this ... Most Valuable Brands for the Year 2017 by The Silicon Review , he was ... making good progress increasing Asymmetrex’s value, but this recognition by Silicon Valley was particularly meaningful. ...
(Date:5/16/2017)... ... May 16, 2017 , ... ... Hi-C metagenomic deconvolution service. ProxiMeta enables researchers to obtain complete, distinct genomes ... insights at lower cost. , “We’re very excited about the commercial launch ...
(Date:5/16/2017)... CA (PRWEB) , ... May 16, 2017 , ... ... medicine technology and cancer diagnostics, has released its ClearID Lung Cancer blood test. ... in lung cancer, this new test is designed to quickly and accurately identify ...
Breaking Biology Technology:
Cached News: