Neuronal differentiation of human neural stem cell grafts in adult rat spinal cord

Neuronal differentiation of human neural stem cell grafts in adult rat spinal cord

Human neural stem cell grafts can show neuronal differentiation in the normal and injured spinal cord of adult rats. Researchers from Johns Hopkins University and Neuralstem Inc, led by Vassilis Koliatsos, grafted neural stem cell grafts derived from spinal cord of a single eight week fetus, into the lower spinal cord of normal or injured immune deficient adult rats. As part of the differentiation, the researchers found that some of these cells grew axons (the long arms of nerve cells) and some were able to form cell to cell contacts (synapses) with motor neurons of the host rats. These results challenge previous assumptions that the spinal cord is unable to support the differentiation of neurons from stem cell grafts.

Although these results are encouraging there is a long way to go before these results might be translated into benefit for patients. For example, although the researchers used neuron-specific cell markers to identify the cells derived from the stem cells, they did not show whether or not these cells can function correctly as neurons, such as by producing electrical impulses. In addition, they did not investigate whether there was any recovery of movement in the injured rats.

A related perspective article by Sally Temple and Natalia Lowry of Albany Medical College discusses the paper's findings further, stressing both the crucial need to repeat this work using different primary lines established from other human embryonic spinal cord cells, the necessity of using different animal models that are not immune deficient, and also the need for future studies that include behavioral analysis of the experimental animals.

Citation: Yan J, Xu L, Welsh AM, Hatfield G, Hazel T, et al. (2007) Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord. PLoS Med 4(2): e39.


Contact: Andrew Hyde
Public Library of Science

Page: 1 2 3

Related biology news :

1. Neuronal activity gives clues to working memory
2. Neuronal cell cultures kept on the straight and narrow
3. Neuronal traffic jam marks early Alzheimers disease
4. Neuronal excitability may hold key to age-related decline in learning and memory
5. Pittsburgh-based team engineers muscle, bone cell differentiation with aid of ink-jet printer
6. Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
7. Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation
8. Possible evidence of cell division, differentiation found in oldest known embryo fossils
9. Genetic tug of war determines sexual differentiation
10. Gladstone researchers hone in on differentiation of heart stem cells
11. Stem cells bring fast direct improvement, without differentiation, in acute renal failure

Post Your Comments:

(Date:8/7/2020)... ... 2020 , ... Nine middle school teachers from eight states ... unique professional development program that provides advanced STEM (science, technology, engineering and math) ... , Created in partnership between the National Stem Cell Foundation and The Gatton ...
(Date:7/22/2020)... ... July 21, 2020 , ... ... and innovation in technology and compliance, announces a new solution to manage regulated ... ensure every layer of their technology stack complies with FDA and global regulations. ...
(Date:7/4/2020)... ... , ... Aesthetics Biomedical (ABM), a leading aesthetics product development ... the products and treatments developed, but also the dedicated team behind the brands ... built by ABM have received several honors already for 2020, each of which ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader in ... “BUILDING FOR LIFE.” The adoption of this taglines comes at a time of ... capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. ...
(Date:7/31/2020)... Mass. and SOMERSET, N.J (PRWEB) , ... July ... ... leading genome editing company, and Catalent, the leading global provider of advanced delivery ... consumer health products, today announced that they have entered into a strategic partnership ...
(Date:7/31/2020)... , ... July 30, 2020 ... ... cloud-based software for the life sciences industry, today announced the release of ... designed specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... MILWAUKEE (PRWEB) , ... July 16, 2020 , ... “We ... at Third Wave Bioactives. “It’s the only technology of its kind on the market ... flavor of onions with the protective capacity of traditional cultured ingredients, creating a natural ...
Breaking Biology Technology:
Cached News: