HOME >> BIOLOGY >> NEWS
Neuronal excitability may hold key to age-related decline in learning and memory

By analyzing the effects of altered neuronal function in mice, researchers have gained new understanding of how changes in a particular neuronal characteristic, neuronal excitability, may negatively impact learning and memory as we age. The work is reported by Geoffrey Murphy and Alcino Silva and their colleagues at the University of California, Los Angeles.

Learning and memory impairments that arise independent of overt pathology are considered to be a normal component of aging. It is estimated that about 40% of people over the age of 65 years suffer from some sort of age-related cognitive decline. The exact cause of these age-related deficits in learning and memory is not currently known, but there have been numerous studies in the past that have implicated age-related changes in two neuronal attributes: a decrease in neuronal excitability, or the ability of neurons to be stimulated to fire, and age-related deficits in synaptic plasticity, or the ability of neurons to change some types of connections to other neurons. In the new study, funded by the National Institutes of Aging, researchers have established the link among neuronal excitability, synaptic plasticity, and aging.

Studying mice that had been genetically engineered to lack a particular ion channel auxiliary subunit, the researchers showed that the mice maintained enhanced neuronal excitability into old age, and, most importantly, that these mice exhibit a reduction in the threshold for the induction of specific forms of synaptic plasticity in other words, these mice appear to change some kinds of inter-neuronal connections more readily than do normal mice of the same age. Furthermore, the aged mutant mice out-performed their age-matched wild-type littermates in the spatial version of the Morris water maze, a laboratory test for learning and memory.

Previous data suggested that in humans, the severity of age-related cognitive decline is affected by the genetic ba
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
8-Nov-2004


Page: 1 2

Related biology news :

1. Neuronal activity gives clues to working memory
2. Neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
3. Neuronal cell cultures kept on the straight and narrow
4. Neuronal traffic jam marks early Alzheimers disease
5. Autism-related proteins control nerve excitability, researchers find
6. Early environmental exposure may accelerate age-related neurodegeneration
7. Fruit flies may pave way to new treatments for age-related heart disease
8. Gene linked to aggressive wet age-related macular degeneration
9. Variation in 3 genes influences risk of age-related macular degeneration
10. Role for macrophages in age-related macular degeneration
11. Researchers uncover genetic clues to a common form of age-related dementia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/14/2020)... ... May 12, 2020 , ... ... accurately and easily project contracted liabilities with payers, providers and pharmacies – ... discounts/rebates to Commercial and Government entities, Copay and Patient Assistance Program liabilities ...
(Date:5/6/2020)... ... May 06, 2020 , ... Sickle Cell Disease Association ... technology company dedicated to improving the quality, safety, efficacy and cost of red blood ... SCDAA deliver on its mission and meet its goals. In 2020 Hemanext will collaborate ...
(Date:5/1/2020)... ... April 30, 2020 , ... InBios International Inc., ... it had been awarded a contract from the Biomedical Advanced Research and Development ... Response at the U.S. Department of Health and Human Services, to develop the ...
Breaking Biology News(10 mins):
(Date:4/1/2020)... ... March 31, 2020 , ... Carterra® Inc., the world leader in ... today that they will use Carterra’s proprietary LSA™ platform to screen hundreds of antibodies ... as early as this summer. , La Jolla Institute for Immunology (LJI) ...
(Date:3/27/2020)... ... March 26, 2020 , ... iFirst Medical Technologies, Inc., ... of COVID-19 nasal swab test. , "COVID-19 poses a grave danger to public health ... "We at iFirst are compelled to act. Broad-based testing and on-the-spot results promise to ...
(Date:3/13/2020)... ... March 12, 2020 , ... ... Microbiome Ireland SFI Research Center (APC), a pioneer in the field of microbiome ... play a significant role in human health, based at University College Cork and ...
(Date:3/10/2020)... , ... March 10, 2020 ... ... full-service cold chain biopharmaceutical engineering firm, is pleased to announce the addition ... on combination medical device qualification and validation in the biopharmaceutical cold chain. ...
Breaking Biology Technology:
Cached News: