HOME >> BIOLOGY >> NEWS
Neutralizing a protein linked to tumor development

In recent years, several proteins and various small synthetic chemicals have been designed to attack cancers by specifically inhibiting the activity of a class of enzymes that are often mutated in tumors - receptor tyrosine kinases. These receptors, which sit on the cell surface, normally stimulate intracellular pathways that control proliferation and other cellular functions in response to growth factors. In tumors, these receptors often have mutations that allow them to become active without growth factor binding, which results in the uncontrolled proliferation that is characteristic of cancer cells.

Reporting their work in the open-access journal PLoS Biology, Domenico Libri and colleagues now show that a class of molecules - called aptamers - may have potential as anticancer drugs. Aptamers - single-stranded nucleic acid molecules that are 50100 bases long and can be selected for their ability to bind directly and tightly to specific proteins - are less likely to be targeted and destroyed by the body's natural defenses than some other types of potential therapeutic molecules.

Libri and colleagues chose to target a particular tyrosine kinase, RET, mutations of which cause multiple endocrine neoplasia (MEN) type 2 syndromes. Using a technique known as whole-cell SELEX (systematic evolution of ligands by exponential enrichment), a process in which large pools of oligonucleotides are enriched for molecules that can distinguish between a real and sham target, Libri and colleagues produced a sequence that not only bound RET but also blocked RET downstream signaling events and subsequent cellular and molecular changes. The researchers suggest that their method can be used to identify macromolecules with potential therapeutic effects against other transmembrane receptors involved in tumorigenesis.


'"/>

Contact: Paul Ocampo
pocampo@plos.org
415-624-1224
Public Library of Science
21-Mar-2005


Page: 1

Related biology news :

1. Penn researchers discover how key protein stops inflammation
2. UCF research links proteins, stem cells and potential Alzheimers treatment
3. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
4. Discovery of new protein could provide new understanding of male fertility
5. Unlocking proteins from their cellular shell
6. Altering a protein makes mice less fearful
7. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
8. MicroRNA works with Ago2 protein to regulate blood cell development
9. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
10. Call for EU to launch major project to map out all our proteins
11. New role for protein in fat cells may improve understanding of obesity and diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global eye tracking market to grow at a CAGR ... Global Eye Tracking Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
Breaking Biology News(10 mins):
(Date:9/25/2017)... ... ... Throughout the month of October, consumers will see thousands of their favorite ... industry expert David Carter is available to explain why so many leading brands and ... demand for non-GMO foods and beverages is gathering momentum, as consumers want to know ...
(Date:9/25/2017)... ... September 25, 2017 , ... Comprehend, ... presentations and demonstrations at SCDM 2017, held September 24-27, 2017 in Orlando. ... and CRO partners for more automated capabilities across evolving data, Comprehend delivers ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... venous leg ulcers is now being assessed in clinical trials in the United ... please talk to your nurse or physician or find your nearest participating clinic ...
(Date:9/21/2017)... ... September 21, 2017 , ... Executives and subject ... most progressive pharma and biotech organizations to do more clinical trials will share ... events in Q4. , DrugDev will demonstrate DrugDev Spark™, the world’s first unified ...
Breaking Biology Technology:
Cached News: