HOME >> BIOLOGY >> NEWS
Neutralizing a protein linked to tumor development

In recent years, several proteins and various small synthetic chemicals have been designed to attack cancers by specifically inhibiting the activity of a class of enzymes that are often mutated in tumors - receptor tyrosine kinases. These receptors, which sit on the cell surface, normally stimulate intracellular pathways that control proliferation and other cellular functions in response to growth factors. In tumors, these receptors often have mutations that allow them to become active without growth factor binding, which results in the uncontrolled proliferation that is characteristic of cancer cells.

Reporting their work in the open-access journal PLoS Biology, Domenico Libri and colleagues now show that a class of molecules - called aptamers - may have potential as anticancer drugs. Aptamers - single-stranded nucleic acid molecules that are 50100 bases long and can be selected for their ability to bind directly and tightly to specific proteins - are less likely to be targeted and destroyed by the body's natural defenses than some other types of potential therapeutic molecules.

Libri and colleagues chose to target a particular tyrosine kinase, RET, mutations of which cause multiple endocrine neoplasia (MEN) type 2 syndromes. Using a technique known as whole-cell SELEX (systematic evolution of ligands by exponential enrichment), a process in which large pools of oligonucleotides are enriched for molecules that can distinguish between a real and sham target, Libri and colleagues produced a sequence that not only bound RET but also blocked RET downstream signaling events and subsequent cellular and molecular changes. The researchers suggest that their method can be used to identify macromolecules with potential therapeutic effects against other transmembrane receptors involved in tumorigenesis.


'"/>

Contact: Paul Ocampo
pocampo@plos.org
415-624-1224
Public Library of Science
21-Mar-2005


Page: 1

Related biology news :

1. Penn researchers discover how key protein stops inflammation
2. UCF research links proteins, stem cells and potential Alzheimers treatment
3. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
4. Discovery of new protein could provide new understanding of male fertility
5. Unlocking proteins from their cellular shell
6. Altering a protein makes mice less fearful
7. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
8. MicroRNA works with Ago2 protein to regulate blood cell development
9. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
10. Call for EU to launch major project to map out all our proteins
11. New role for protein in fat cells may improve understanding of obesity and diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... April 20, 2017  Eli Lilly and Company (NYSE: ... evaluating galcanezumab for the prevention of migraine at the ... take place April 22-28, 2017, in Boston ... abstracts at AAN, including safety and patient outcomes data ... with a reduction in monthly migraine headache days among ...
(Date:4/20/2017)... ... April 20, 2017 , ... NetDimensions appoints Bill Mastin, a learning technology ... years of experience in the learning technologies industry, Mastin joins NetDimensions from the New ... Group plc (LTG). At LEO, Mastin served as SVP of the North America offices ...
(Date:4/20/2017)... ... ... Parallel6™ , the leader in mClinical™ technologies for improving patient enrollment, ... of the 2017 Top 10 eClinical Trial Management Solution Providers by Pharma Tech ... take pride in honoring Parallel6 as one of the top 10 companies that are ...
(Date:4/20/2017)... N.J. and PETACH TIKVAH, Israel ... BCLI), a leading developer of adult stem cell technologies for ... Executive Officer, will present at the Alliance for Regenerative Medicine,s ... Day on Thursday, April 27, 2017 at 09:40 EDT in ... Ralph Kern , MD, MHSc, Chief Medical Officer & ...
Breaking Biology Technology:
Cached News: