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New $1.16 million study investigates how dietary iron is used by cells

usly in the cells membranes, at the interfaces between membranes and soluble compartments or within soluble compartments.

The researchers will test this form-function model of ionic iron metabolism by focusing on three steps critical to maintaining the proper balance of iron in cells: 1) the reduction of ferric to ferrous iron and the subsequent transport of ferrous iron into a cell; 2) the hand-off of this ferrous iron from a membrane protein to iron chaperones in the cells cytoplasm; and 3) the utilization of this ionic iron for the activation of essential iron-containing enzymes.

These three components of cellular iron metabolism are relatively under-investigated, said Kosman, yet they represent the essence of cell iron metabolism in all organisms.

Understanding the intermediary metabolism of iron is one of the primary objectives of a program announcement from NIH titled Metals In Medicine, he noted. This announcement encourages studies that lead to the identification and characterization of the macromolecular players and vesicular compartments involved in metal ion homeostasis and metal trafficking.


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Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
21-Jun-2007


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