HOME >> BIOLOGY >> NEWS
New 'asthma gene' could lead to new therapies

ANN ARBOR, Mich.---A gene that is strongly associated with a risk of developing childhood onset asthma was identified by an international team of scientists, whose findings are published today in the journal Nature.

In a genetic study of more than 2,000 children, scientists from the University of Michigan and colleagues from London, France and Germany found genetic markers that dramatically increase a child's risk for asthma. These markers are located on chromosome 17, and children with this marker had higher levels of a new gene called ORMDL3 in their blood, which occurs in higher amounts in children with asthma. The presence of the disease-associated version of ORMDL3 increases the risk of asthma by 60-70 percent, the study suggests.

"In terms of an asthma gene, there have been quite a few reports but not one that can be clearly reproduced in samples," said Goncalo Abecasis, associate professor at the U-M School of Public Health. "I think eventually it will lead to new therapies because it points to a specific biological molecular pathway. Once we understand the biology and we know the players, it's possible to target with specific drugs."

Childhood asthma treatments are heavily focused on allergic responses, since most children with asthma also have many allergies. The discovery of a so-called 'asthma gene' would provide a new set of mechanisms to try and modify and manage childhood asthma, Abecasis said.

"Before we finished the paper, we would have guessed (ORMDL3) would be a gene with a well-understood role in allergic responses, but that is not what we found," said Abecasis, noting that the gene has no known relation to allergic responses.

Asthma, a complex disease caused by a combination of genetic and environmental factors, is the most common chronic disease of childhood. Asthma occurs in 7-10 percent of children in the United States and one child in seven in the United Kingdom. Its prevalence differs
'"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
4-Jul-2007


Page: 1 2 3

Related biology news :

1. Scientists discover rare gene-for-gene interaction that helps bacteria kill their host
2. Personality-gene makes songbirds curious
3. Jefferson scientists find guardian genes choices crucial to stopping cancer process
4. Diabetes gene may be linked to polycystic ovary syndrome
5. UVa finds Alzheimers gene protects children from severe diarrhea
6. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
7. UGA scientists discover bacterial switch gene that regulates oceans sulfur emissions into the air
8. Research team identifies human memory gene
9. How butterflies got their spots: A supergene controls wing pattern diversity
10. Dont care for broccoli? A receptor genes variation suggests an evolutionary excuse
11. Teens with deletion syndrome confirm genes role in psychosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... , ... Lajollacooks4u has expanded its team as it gears up for a ... seen record growth in 2019, having hosted a multitude of team-building events and cooking ... visited the company’s La Jolla-based venue, and Lajollacooks4u has worked hard to accommodate the ...
(Date:8/27/2019)... Fla. (PRWEB) , ... August 27, 2019 , ... ... in life science and drug development. This episode is scheduled to broadcast 4Q/2019. ... explore Debiopharm, a biopharmaceutical research, development, investment and manufacturing company. The show will ...
(Date:8/21/2019)... ... August 20, 2019 , ... Cutting Edge ... for the spine, today announced the 510(K) clearance of its novel SI joint ... is proven to improve osseointegration through superior hydrophilicity and optimized surface chemistry, as ...
Breaking Biology News(10 mins):
(Date:9/4/2019)... , ... September 03, 2019 ... ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, gene ... Science & Technology will present at the upcoming Nordic Life Science Days ...
(Date:8/27/2019)... ... 27, 2019 , ... Dr. Kim Carlson is a veterinary surgeon practicing in ... Surgical Group , a new surgical practice in San Mateo. She is currently ... more veterinary specialists as the practice grows. , When asked about the opening of ...
(Date:8/15/2019)... (PRWEB) , ... August 15, 2019 , ... ... Scientific Advisory Board. Mr. Lawrence is a member of the Institute of Food ... Safety and Health (IFSH) Advisory Board, Joint Institute for Food Safety and Applied ...
(Date:8/6/2019)... ... August 06, 2019 , ... The San Diego Biotechnology ... the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech community and ... to promote the region and attract external employers, investors, scientists, and others who ...
Breaking Biology Technology:
Cached News: