HOME >> BIOLOGY >> NEWS
New biomarkers could help doctors spot Alzheimer's and other neurodegenerative diseases

Neurodegenerative diseases like Alzheimer's and Parkinson's in their early stages can be difficult for physicians to spot, and many diagnoses are incorrect. A finding by researchers at the University of Washington and Harborview Medical Center may soon help in the diagnosis of such diseases.

The researchers have used an advanced technique to identify proteins in the human body, known as biomarkers, that can indicate whether a patient has a particular neurodegenerative disease, or determine the progression of a disease. Searching for biomarkers is nothing new, but the researchers used a cutting-edge proteomics system, called iTRAQ, that relies on isotopic labeling of protein molecules. The system could help a physician determine the amount of a biomarker a patient may have in his body, which can help with diagnosis.

In a large multi-site study, the researchers identified more than 1,500 potential biomarkers in cerebrospinal fluid from patients with one of three neurodegenerative diseases: Alzheimer's, Parksinson's, or dementia with Lewy bodies (DLB). Researchers identified different sets of potential biomarkers corresponding to each disease; each of the proteins are linked specifically to one of the diseases. The results appear in the new issue of the Journal of Alzheimer's Disease.

"We're getting very close to being able to use these biomarkers for the clinical diagnosis of Alzheimer's and Parkinson's disease, and dementia with Lewy bodies," said the study's lead author, Dr. Jing Zhang, associate professor of pathology at the UW. His lab is at Harborview Medical Center. "This is a major improvement on other biomarker detection techniques."

Alzheimer's, Parkinson's, and other neurodegenerative diseases affect millions of people in the United States, and the toll of the diseases is expected to worsen as the Baby Boomer generation grows older. Though researchers and clinicians are learning more and more about the diseases, there i
'"/>

Contact: Justin Reedy
jreedy@u.washington.edu
206-685-0382
University of Washington
11-Aug-2006


Page: 1 2

Related biology news :

1. Contributing membership in the biomarkers consortium surges to 30 companies and nonprofits
2. Jaap Sinninghe Damst awarded the Vernadsky Medal for innovative use of biomarkers
3. Genes and biomarkers that allow doctors to choose the right therapy for the right patient
4. AACR, FDA and NCI announce cancer biomarkers collaborative at the AACR 2007 annual meeting
5. New genetic biomarkers could predict coronary heart disease
6. Researchers identify ovarian cancer biomarkers
7. Researchers find two biomarkers with potential to predict breast cancer spread
8. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
9. New biomarkers for lupus found
10. Signaling proteins may represent biomarkers for melanoma
11. Studies throw light on biomarkers which predict the subsets of patients where gefitinib has the greatest benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... , ... August 25, 2020 , ... ... manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products, ... Annual PEGS Boston Virtual Conference & Expo, taking place between Aug. 31 – ...
(Date:8/21/2020)... (PRWEB) , ... August 19, 2020 , ... ... the premier conference and expo uniting life science, data science, informatics and IT ... sessions. , “In this period of uncertainty and change, Bio-IT takes the leadership ...
(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle school teachers from ... Program, a unique professional development program that provides advanced STEM (science, technology, engineering ... teachers nationwide. , Created in partnership between the National Stem Cell Foundation and ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... WILMINGTON, Del. (PRWEB) , ... August 29, 2020 ... ... of a new Animal Nutrition manufacturing capability in Wuxi, China. The new plant ... DuPont’s global quality standards and advanced technology. , “This facility will improve ...
(Date:8/15/2020)... ... August 13, 2020 , ... ... 5000 list, the most prestigious ranking of the nation’s fastest-growing private companies. The ... economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... engineering firm, is making available for free its new white paper – ... transport simulation testing into today’s biologics licensing application (BLA). In response, Modality ...
(Date:8/7/2020)... WOODLANDS, Texas (PRWEB) , ... August 06, 2020 ... ... therapy and DNA vaccine industries, announces it has closed on the purchase of ... Technology Park in Conroe, TX and includes over 21 acres in the initial ...
Breaking Biology Technology:
Cached News: