HOME >> BIOLOGY >> NEWS
New biomarkers for lupus found

WINSTON-SALEM, N.C. A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease.

The biomarkers are micro-ribonucleic acids (micro-RNAs), said Nilamadhab Mishra, M.D. He and colleagues reported at the American College of Rheumatology meeting in Washington that they had found profound differences in the expression of micro-RNAs between five lupus patients and six healthy control patients who did not have lupus.

"We are the first to show that these micro-RNAs are a problem in human lupus," said Mishra, an assistant professor of rheumatology.

Mishra said microRNAs are a class of small chains of ribonucleic acid that have important regulatory functions in the body, particularly in suppressing genes. (RNA serves as the template for translation of genes into proteins.)

The research is part of Mishra's broader focus on histones, the tiny spools in the nuclei of cells around which DNA winds and compacts when it is not in the process of copying in cell division. Changes in these histones, called epigentic changes, can alter gene expression and the proteins these genes produce without altering the underlying DNA.

In the new study, the researchers found 40 microRNAs in which the difference in expression between the lupus patients and the controls was more than 1.5 times, and focused on five micro-RNAs where the lupus patients had more than three times the amount of the microRNAs as healthy controls, and one, called miR 95 where the lupus patients had just one third of the gene expression of the microRNA of the controls.

The team reported the lesser amount of miR 95 "results in aberrant gene expression in lupus patients."

Furthermore, Mishra said, the microRNAs are associated with enzymes called histone deacetylases which provide "further rationale for the use of histone deacetylase inhibitors (HDIs) for the treatment of lupus."


'"/>

Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
10-Nov-2006


Page: 1 2

Related biology news :

1. Contributing membership in the biomarkers consortium surges to 30 companies and nonprofits
2. Jaap Sinninghe Damst awarded the Vernadsky Medal for innovative use of biomarkers
3. Genes and biomarkers that allow doctors to choose the right therapy for the right patient
4. AACR, FDA and NCI announce cancer biomarkers collaborative at the AACR 2007 annual meeting
5. New genetic biomarkers could predict coronary heart disease
6. Researchers identify ovarian cancer biomarkers
7. Researchers find two biomarkers with potential to predict breast cancer spread
8. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
9. New biomarkers could help doctors spot Alzheimers and other neurodegenerative diseases
10. Signaling proteins may represent biomarkers for melanoma
11. Studies throw light on biomarkers which predict the subsets of patients where gefitinib has the greatest benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply ... a time. So which eye do you rinse first if a dangerous substance enters both ... Duo Eye Wash with its unique dual eye piece. , “Whether its dirt and ...
(Date:10/11/2017)... ... , ... Disappearing forests and increased emissions are the main causes of the ... Especially those living in larger cities are affected by air pollution related diseases. , ... pollution-affected countries globally - decided to take action. , “I knew I had to ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time ... US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. ... US2020. , US2020’s mission is to change the trajectory of STEM education in ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
Breaking Biology Technology:
Cached News: