HOME >> BIOLOGY >> NEWS
New biomarkers for lupus found

WINSTON-SALEM, N.C. A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease.

The biomarkers are micro-ribonucleic acids (micro-RNAs), said Nilamadhab Mishra, M.D. He and colleagues reported at the American College of Rheumatology meeting in Washington that they had found profound differences in the expression of micro-RNAs between five lupus patients and six healthy control patients who did not have lupus.

"We are the first to show that these micro-RNAs are a problem in human lupus," said Mishra, an assistant professor of rheumatology.

Mishra said microRNAs are a class of small chains of ribonucleic acid that have important regulatory functions in the body, particularly in suppressing genes. (RNA serves as the template for translation of genes into proteins.)

The research is part of Mishra's broader focus on histones, the tiny spools in the nuclei of cells around which DNA winds and compacts when it is not in the process of copying in cell division. Changes in these histones, called epigentic changes, can alter gene expression and the proteins these genes produce without altering the underlying DNA.

In the new study, the researchers found 40 microRNAs in which the difference in expression between the lupus patients and the controls was more than 1.5 times, and focused on five micro-RNAs where the lupus patients had more than three times the amount of the microRNAs as healthy controls, and one, called miR 95 where the lupus patients had just one third of the gene expression of the microRNA of the controls.

The team reported the lesser amount of miR 95 "results in aberrant gene expression in lupus patients."

Furthermore, Mishra said, the microRNAs are associated with enzymes called histone deacetylases which provide "further rationale for the use of histone deacetylase inhibitors (HDIs) for the treatment of lupus."


'"/>

Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
10-Nov-2006


Page: 1 2

Related biology news :

1. Contributing membership in the biomarkers consortium surges to 30 companies and nonprofits
2. Jaap Sinninghe Damst awarded the Vernadsky Medal for innovative use of biomarkers
3. Genes and biomarkers that allow doctors to choose the right therapy for the right patient
4. AACR, FDA and NCI announce cancer biomarkers collaborative at the AACR 2007 annual meeting
5. New genetic biomarkers could predict coronary heart disease
6. Researchers identify ovarian cancer biomarkers
7. Researchers find two biomarkers with potential to predict breast cancer spread
8. AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
9. New biomarkers could help doctors spot Alzheimers and other neurodegenerative diseases
10. Signaling proteins may represent biomarkers for melanoma
11. Studies throw light on biomarkers which predict the subsets of patients where gefitinib has the greatest benefit

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New biomarkers for lupus found

(Date:10/30/2014)... researchers have developed a suite of technologies that can ... which has applications in everything from search and rescue ... developed a platform for computer-mediated communication between humans and ... interpreting dogs, behavioral signals and sending them clear and ... assistant professor of computer science at NC State and ...
(Date:10/29/2014)... Cancer suffers who lose their hair as a consequence ... that will improve the scalp cooling technology that prevents ... and is being pioneered by global scalp cooling manufacturing ... with the biology department of the University of Huddersfield. ... Omar Hussain, who has a background in the pharmacology ...
(Date:10/29/2014)... have been blamed for increasing the risk of ... family history of schizophrenia, are widely accepted. Others, ... a parasite transmitted by soil, undercooked meat and ... A new study by Gary Smith, professor of ... Pennsylvania,s School of Veterinary Medicine, used epidemiological modeling ...
Breaking Biology News(10 mins):New tech aims to improve communication between dogs and humans 2New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3
(Date:10/30/2014)... A new report, commissioned by BioCrossroads and ... in-depth look at Indiana,s capital ... two different time frames: 1993 to 2002 and 2003 ... opportunities for investment growth.  The Life Science Innovation ... gains in innovation dollars as well as an increase ...
(Date:10/30/2014)... – The severe flooding that devastated a wide swath ... if the bridges, roads and other infrastructure had been ... the University of Colorado Denver. , "People need to ... Kim, PhD, associate professor of structural engineering at the ... lead author the study. "There is an assumption that ...
(Date:10/27/2014)... , October 27, 2014 ... to produce, exhibit and sell its artificial "lower ... impeach their patent.      (Photo: ... years of fighting, the definitive judgement has arrived: ... produces innovative and accessible hi-tech prostheses with composite ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 The ... Oncology, Genetics, Microbiology), Technology (PCR, INAAT, DNA Sequencing), ... Reagent, Service, Software) - Global Forecast to 2018” ... restraints, challenges, opportunities, current market trends, and strategies ... the estimates and forecasts of the revenue and ...
Breaking Biology Technology:New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5CU Denver study says upgrading infrastructure could reduce flood damage 2Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5
Cached News: