HOME >> BIOLOGY >> NEWS
New blood test might offer early warning of deep belly fat

Measuring levels of a chemical found in blood offers the best indicator yet of the amount of fat surrounding abdominal organs, according to a new study of lean and obese individuals reported in the July issue of Cell Metabolism, a publication of Cell Press. The buildup of such visceral fat is of particular health concern as it has been linked to insulin resistance, type 2 diabetes, and heart disease risk.

The researchers, including Barbara Kahn and Timothy Graham of Harvard Medical School and Matthias Blher of the University of Leipzig in Germany, showed that retinol-binding protein 4 (RBP4) is produced in much greater amounts by visceral fat compared to the subcutaneous fat that lies just beneath the skin. Moreover, they report that blood serum levels of RBP4 jump in people who are obese, who have double or even triple the concentrations found in individuals of normal weight.

We believe that in the near future, measurements of RBP4 serum concentrations might serve as a novel biomarker for visceral obesity and increased risk for type 2 diabetes and other adverse outcomes of visceral obesity, said Blher. In addition, pharmacological interventions that reduce RBP4 levels might be a new approach in the treatment of metabolic syndrome and visceral obesity.

Prior to 2005, when Kahns group showed that elevating RBP4 levels in mice causes insulin resistance and lowering them in obese mice can improve insulin sensitivity, the only known function of RBP4 was to carry vitamin A (also known as retinol) in the blood, Kahn said.

The researchers went on to show that serum RBP4 concentrations are also elevated in insulin-resistant individuals with obesity, type 2 diabetes, or impaired glucose tolerance, and even in otherwise normal people with a strong family history of diabetes. Likewise, interventions designed to improve insulin sensitivity, such as exercise training, lifestyle modification, or gastric banding surgery also lead to a d
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
10-Jul-2007


Page: 1 2

Related biology news :

1. High blood pressure, low energy -- a recipe for heart failure
2. Brain blood flow gives clues to treating depression
3. Study finds gender differences in renal and other genes contributing to blood pressure
4. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
5. Research aims to identify markers for menopausal women at risk for deadly blood clot
6. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
7. A low expression of MX2 gene exists in the white blood cells of narcoleptics
8. How a pain in the neck could be bad for your blood pressure
9. Penn researchers discover pathway that eliminates genetic defects in red blood cells
10. U-M team identifies gene that regulates blood-forming fetal stem cells
11. MicroRNA works with Ago2 protein to regulate blood cell development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... 2019 , ... Join Jonathan Riek, PhD, VP, Musculoskeletal & Metabolic Imaging, ... at 1pm EDT to learn about two common imaging methods in NAFLD/NASH to aid ... most common diffuse liver disease, with a worldwide prevalence of 20-46 percent. NAFLD can ...
(Date:8/9/2019)... (PRWEB) , ... August 09, 2019 , ... With a ... patients, more and more patients will visit urgent care centers (UCC) in the coming ... Information. The report, The Market for Urgent Care Centers , is a detailed ...
(Date:8/6/2019)... Wis. (PRWEB) , ... August 06, 2019 , ... ... health, sustainability, and environmental concerns. One plant-based food in particular quickly entered the ... animal-meat counterparts, product developers use a thermogelling and emulsifying ingredient such as methyl ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... (PRWEB) , ... August 06, 2019 , ... ... Radio (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast focused ... growth. SDBN BUZZ podcast will also serve to promote the region and attract ...
(Date:8/4/2019)... ... 2019 , ... Cirtec Medical Corporation, a strategic outsourcing partner for complex medical ... construction on a 30,000 sq. ft. manufacturing facility in the Coyol free zone, ... facility, which is expected to be fully operational by the end of the year, ...
(Date:7/19/2019)... ... 2019 , ... Global precision motion and piezo technology solutions ... facilities in Lederhose, Germany, increasing their current footprint by half again. , The ... addition to general office space, a significant increase to its existing 129,000ft² structure. ...
(Date:7/17/2019)... ... 2019 , ... Quidel is the market leader in point-of-care ... and Siemens Healthineers and Response Biomedical also are among the top companies. The ... (POC) Diagnostics . , Quidel is a market leader in rapid immunoassays and ...
Breaking Biology Technology:
Cached News: