HOME >> BIOLOGY >> NEWS
New cell type identified in cancer development

COLUMBUS, Ohio -- Scientists have discovered a new type of cell that appears to play a role in the development of cancer a highly volatile, precancerous stem cell that can either remain benign or become malignant, depending upon environmental cues. The finding may help define the role of cancer stem cells in the growth and recurrence of the disease as well as offer new options for cancer prevention, detection and treatment.

Current cancer stem cell theory holds that tumors are comprised of a variety of cell types. Among them is a small subset of rather primitive cells that, like other stem cells in the body, are self-sustaining, self-renewing and multipotent, or capable of creating other types of cells and tissues. These cells are different from normal stem cells, however, in that injecting even as few as 100 of them into laboratory animals will cause cancer. Scientists have dubbed these cancer stem cells.

Cancer stem cells were first identified in leukemia, but they have also been found in breast, brain, colon and prostate cancers. Because they are rather unstable, they are notoriously tricky to isolate and describe. They are also resistant to virtually any kind of treatment, and some scientists believe they are the reason cancer recurs. Until now, no one has known how they arise.

But a team of scientists, led by Dr. Jian-Xin Gao, a researcher in the department of pathology at Ohio State University Medical Center, has identified a new set of cells he calls precancerous stem cells (pCSCs).

These cells share some of the characteristics full-fledged cancer stem cells have, but they are different in that they respond to distinct cell signals that determine their ultimate fate whether they will continue to grow into cancer or cancer stem cells, lie inactive or be eradicated by the bodys immune system.

"These hybrid cells are very complex. They have properties of normal and abnormal stem cells, and do not always
'"/>

Contact: Michelle Gailiun
michelle.gailiun@osumc.edu
614-293-3737
Public Library of Science
13-Mar-2007


Page: 1 2 3

Related biology news :

1. Link identified between Alzheimers disease and glaucoma
2. Gene identified for Crohns disease in children
3. New gene mutation identified in common type of dementia
4. Allergy molecule identified
5. Gene responsible for common hearing loss identified for first time
6. Muscle weakness: New mutation identified
7. Tumor vessels identified by unique molecular markers
8. Extra-aggressive form of idiopathic pulmonary fibrosis identified
9. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
10. Pediatric cancer stem cell identified: understanding the origin of ERMS
11. New host species for avian influenza identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2018)... ... 2018 , ... USDM Life Sciences , the leading risk management, technological ... received the 2018 Services Partner of the Year, Awarded for Innovation from Box, a ... Development and Platform Sales, Niall Wall and received by USDM Life Sciences CEO, Kevin ...
(Date:8/26/2018)... LINDA, Calif. (PRWEB) , ... August 23, 2018 ... ... the potential it has for increased sensitivity and specificity over more commonly used ... the instrumentation and the added burden of development and validation of methods that ...
(Date:8/23/2018)... (PRWEB) , ... August 22, 2018 , ... ... release of LimitLIS® 4.0, the latest version of its rapidly growing cloud-based laboratory ... LimitLIS® Toxicology Edition, as well as the company’s triple digit growth throughout 2018, ...
Breaking Biology News(10 mins):
(Date:8/31/2018)... ... August 29, 2018 , ... A recent expedition ... Southampton and the Institute of Industrial Science, the University of Tokyo, demonstrated how ... the exploration and study of hard to reach deep sea ecosystems, like intermittently ...
(Date:8/29/2018)... ... August 28, 2018 , ... Inc. Magazine ... has been ranked in 1138th place on the 27th annual Inc. 5000, the ... list represents the most successful companies within the American economy’s most dynamic segment ...
(Date:8/26/2018)... ... 23, 2018 , ... LabRoots , the leading provider ... world, will host the 4th Annual Microbiology and Immunology Virtual Event September 12-13. ... various research areas including medicine, agriculture, and space. , During the free, ...
(Date:8/21/2018)... (PRWEB) , ... August 21, ... ... a software company specializing in medical device compliance and commercialization, has just ... Cockpit® platform. , Written and presented by Dr. Mario Kossmann, ESEP at ...
Breaking Biology Technology:
Cached News: