New clues to stroke role in Alzheimer's

Researchers have discovered key details of how stroke or traumatic brain injury can trigger Alzheimers disease (AD) by enhancing formation of brain-clogging amyloid plaques. Their experiments established that executioner enzymes that kill brain cells during stroke or head trauma also interfere with the normal disposal of an enzyme that helps generate plaque. This interference increases the level of the enzyme in brain cells, they found.

The researchers, led by Giuseppina Tesco and Rudolph Tanzi of Massachusetts General Hospital, reported their findings in the June 7, 2007, issue of the journal Neuron, published by Cell Press.

The researchers sought to understand the mechanism by which stroke or brain injury causes the increase of an enzyme called BACE in the brain. BACE is a protein-cleaving enzyme that snips apart a brain protein called amyloid precursor protein to form a shorter protein called A beta peptide. It is this A beta peptide that is the building block for the amyloid plaques that are a hallmark of AD.

The researchers discovered that particular enzymes produced during brain injury, called caspases, somehow also enable BACE to linger in brain cells. Caspases are so-called executioner enzymes that destroy brain cells such as those damaged by oxygen deprivation during stroke.

In further exploring the link between caspase activation and higher BACE levels, the researchers found that one of the proteins snipped apart by caspase activity is GGA3. This protein is an adaptor protein necessary for shepherding BACE to the cells garbage disposal machinery, the lysosome. The researchers found that caspase snipping of GGA3 not only eliminates GGA3's ability to tag BACE for destruction but that the resulting fragments of GGA3 actively interfere with BACE disposal.

To test the role of GGA3, the researchers silenced activity of the GGA3 gene in brain cells, finding that the silencing caused increased levels of BACE an

Contact: Erin Doonan
Cell Press

Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Brain blood flow gives clues to treating depression
3. Chronic fatigue -- clues in the blood
4. Stressed-out African naked mole-rats may provide clues about human infertility
5. University of Manchester researchers reveal clues to new genes behind rheumatoid arthritis
6. Neuronal activity gives clues to working memory
7. Virus widely used in gene therapy research yields important clues to genomic instability
8. DNA clues to inform conservation in Africa
9. New clues for treatment of disease that causes accelerated aging
10. Ape gestures offer clues to the evolution of human communication
11. Genome-wide search unearths surprising clues for diabetes and triglycerides

Post Your Comments:

(Date:10/26/2019)... ... October 23, 2019 , ... ... nanotube surface that demonstrated the FDA requirements for nanotechnology. , “We are ... This nanotechnology plays an important role in achieving Nanovis’ goal to reduce the ...
(Date:10/26/2019)... LA PLATA, Md. (PRWEB) , ... October 25, ... ... attended an in-office training on myofunctional therapy in La Plata, MD. Orofacial myofunctional ... restrict how a patient eats, sleeps and speaks. This can include anything from ...
(Date:10/19/2019)... (PRWEB) , ... October 18, 2019 , ... ... on Applications of Lasers & Electro-Optics (ICALEO) was recently held in Orlando, ... and decision-makers from around the world, the event hosted dialogue with a deeper ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... (PRWEB) , ... November 05, 2019 , ... Ole, a German Shepherd, was demonstrating signs ... stairs and jumping. Though his energy level and his willingness to play were normal, ... surgeon Dr. Holly Mullen of VCA Emergency Animal Hospital and Referral Center in ...
(Date:11/2/2019)... ... 31, 2019 , ... Join Patrick Raber, PhD, Manager, Research ... on Friday, November 15, 2019 at 1pm EST to learn about immunoSEQ ... T-cell receptors (TCRs) and B-cell receptors (BCRs), has been widely utilized to understand ...
(Date:10/30/2019)... ... , ... While using cold plasma to kill cancer cells isn’t an entirely ... Mines & Technology are exploring new ways to regulate cold plasma technology to ... the technique would prove to be a drug-free, minimally invasive cancer treatment that would ...
(Date:10/29/2019)... ... October 28, 2019 , ... CaroGen Corporation , a ... , Professor Jack R Wands, MD, of Brown University , ... Professor Gil Mor, MD, PhD, of Wayne State University, formerly a professor ...
Breaking Biology Technology:
Cached News: