"Given the limited expression of p75, the discovery of TAJ function is an important step for understanding the regulation of axon regeneration," wrote Mi and colleagues.

Wrote Park and colleagues, "The implication that more than one TNF receptor member may be involved in myelin inhibition adds a new level of complexity to designing therapeutic strategies for treating CNS injury." They cited studies showing that TNF receptors are expressed in many types of cells in the CNS and are intimately involved in inflammatory responses that also play a role--perhaps harmful, perhaps beneficial to regeneration or recovery--in regulating response to injury. "Further characterization of the underlying mechanisms of these findings and their relation to myelin inhibition may provide important insights into designing therapeutic strategies to block myelin inhibition and cell death in the context of CNS injury," they wrote.

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Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
2-Feb-2005