New databases put wings on search for bipolar risk genes

A novel, free, public online database opening this week should greatly speed efforts to find genes linked to increase risk of bipolar disorder. The Bipolar Disorder Phenome Databasea joint project of Johns Hopkins Psychiatry and the National Institute of Mental Healthis the first of its kind, offering detailed descriptions of symptoms and course of disease on more than 5,000 people with bipolar illness, a mood disorder commonly marked by alternating bouts of depression and manic or overexcited behavior.

Because DNA samples also are available for this group, the database will let researchers correlate specific symptoms with sequences of genetic material. The new database, available at http://www.hopkinsmedicine.org/Psychiatry/moods/bioinformoodics/index.html is meant to complement the massive bodies of genetic data generated already by the Human Genome Project, the International HapMap Consortium and the Genetic Analysis Information Network.

This database describes the clinical picture of bipolar disorder in the fullest detail possible, says James Potash, M.D., who led the Hopkins portion of efforts to assemble the site. It also lets us pick out meaningful clusters of symptoms that will ultimately help identify genes.

Using this newer clinical subtyping approach to gene hunting, scientists winnow out pure groups of patients with a key characteristiclike those whose bipolar disorder (BD) begins earlier than usual or those who also experience panic attacks. Suspect stretches of DNAincluding genesare more likely to stand out in such groups. The approach has been effective in finding genes associated with Alzheimers disease and breast cancer, Potash says.

Collecting accurate descriptions of patients in large enough numbers to ensure reliable results is costly and time-consuming, he adds. The Bipolar Disorder Phenome Database lets re

Contact: Nick Zagorski
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. Air contaminants databases ease healthy homes planning
2. Free access to world-class biological databases for European science thanks to FELICS
3. Hypothyroidism clearly linked to mood swings
4. Scientists find hormone activity explains adolescent mood swings
5. Crickets on Hawaiian Island develop silent wings in response to parasitic attack
6. Protowings may have helped bird ancestors cover rough terrain
7. Fruitfly study shows how evolution wings it
8. Bats use touch receptors on wings to fly, catch prey, study finds
9. Birds that sing with their wings to woo
10. Alarm pheromone causes aphids to sprout wings
11. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research

Post Your Comments:

(Date:8/26/2020)... SHANGHAI (PRWEB) , ... August 24, 2020 , ... ... approaches for the treatment of chronic inflammatory and fibrotic diseases, today announced that ... Vice President of Drug Discovery. , Dr. Canan previously served as Executive Director ...
(Date:8/23/2020)... THE WOODLANDS, Texas (PRWEB) , ... August 21, ... ... from Rigaku Corporation has been published and is now available ... on single crystal X-ray diffraction—serves the X-ray analysis community, presenting current news and ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners Chairman ... Operations executive with expertise in clinical trial planning and feasibility, regulatory inspection readiness, ... Consultant. Throughout his career, Mr. Movahhed has helped design and manage oncology, neurology, ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... R3 Stem ... injections for only $3950. With 50 million stem cells total, patients may choose which ... cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and ... a strategic partnership whereby Catalent will provide support for the development, manufacturing, and ...
(Date:7/22/2020)... , ... July 22, 2020 , ... Join experts from ... Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar on ... regulating body in China for drugs and medical devices. Specifically, for medical devices, the ...
Breaking Biology Technology:
Cached News: