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New drug may aid battle against nicotine addiction, Alzheimer's and other disorders

Irvine, Calif., Jan. 12, 2005 -- Along with aiding efforts to study addicted smokers, a new drug that attaches only to areas of the brain that have been implicated in nicotine addiction may help studies of people battling other disorders such as Alzheimer's disease and schizophrenia.

Developed by UC Irvine Transdisciplinary Tobacco Use Research Center scientists, the new drug Nifrolidine is a selective binding agent that identifies specific areas of the brain responsible for decision-making, learning and memory. Lead researcher Jogeshwar Mukherjee, UCI associate professor of psychiatry and human behavior, developed Nifrolidine to measure a subtype of nicotine receptors in the living brain by using an imaging technique, positron emission tomography, more commonly known as PET scans. After proving the drug's effectiveness, Mukherjee believes the drug will have implications for other conditions, as well.

Study results appear in the January issue of the "Journal of Nuclear Medicine."

"Nifrolidine is suited to provide reliable, quantitative information of these receptors and may therefore be very useful for future human brain imaging studies of nicotine addiction and other clinical conditions in which these brain regions have been implicated," Mukherjee said.

He found in animal tests that Nifrolidine binds to receptors in the temporal and frontal cortex, areas that are responsible for learning and memory as well as reasoning, planning, problem solving and emotion. According to Mukherjee, patients with Alzheimer's disease have been known to have a 30 percent to 50 percent loss of these receptors "If there is a gradual loss of these receptors over time, Nifrolidine could be a potential marker for early diagnosis of Alzheimer's disease," Mukherjee said.

Scientists have known that nicotine's action on these receptors elicits dopamine in various brain regions implicated in nicotine addiction and other disorders. Nicotine acts by ope
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Contact: Louri Groves
lgroves@uci.edu
949-824-9307
University of California - Irvine
12-Jan-2005


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