HOME >> BIOLOGY >> NEWS
New drug shows promise as powerful anticancer agent

Research published in the March issue of the journal Cancer Cell describes a small molecule inhibitor of polo-like kinase1 (Plk1) that could lead to a new avenue for targeted cancer therapy. The compound, ON01910, is a potent inhibitor of human tumors in a mouse model system and has low toxicity. The results of this study have led to clinical evaluation of this compound in phase I clinical trials.

Plk1 is a molecule that plays a key role in driving cell division. High levels of Plk1 have been observed in many human tumors, and studies using various laboratory techniques have shown that inhibition of Plk1activity leads to cell death. "Because all signaling pathways that have gone awry in a cancer cell ultimately affect cell proliferation, a reasonable approach to cancer therapy is to develop inhibitors that block the function of a critical molecule that is required by a tumor cell to complete cell division," explains lead author Dr. E. Premkumar Reddy from Temple University School of Medicine. "One such molecule appears to be Plk1."

Dr. Reddy and colleagues examined the effects of Plk1 inhibitor ON01910 on tumor growth in several animal models. The researchers found that ON01910 arrests cell division in a variety of human cancer cells, including cells that are notoriously resistant to commonly used chemotherapeutic agents. The compound significantly inhibited a wide variety of human tumors, including liver, breast, and pancreatic cancers that were grown in mice. ON01910 was also highly effective and, in many cases, strongly synergistic when tested in combination with other chemotherapeutic agents. Studies examining normal human cells show that, in contrast to tumor cells, they are not influenced by ON01910.

The authors suggest that because ON01910 is highly effective in combination with other chemotherapies and appears to be nontoxic, it may be beneficial for treatment of some advanced cancers that are resistant to conventional therapies. "Cli
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
14-Mar-2005


Page: 1 2

Related biology news :

1. Clones on task serve greater good, evolutionary study shows
2. Research shows skeleton to be endocrine organ
3. An early ape shows its hand
4. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
5. Huntingtons disease study shows animal models on target
6. Research shows NPD1 protects a key component of vision
7. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
8. Chitin from lobster shell shows great healing and bio-stimulant properties
9. Study shows cane sugar, corn sweeteners have similar effects on appetite
10. New research shows vaginal bacteria vary among healthy women, need customized treatment
11. Global warming is evaporating Arctic ponds, new study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... SOUTHFIELD, Mich. (PRWEB) , ... August 11, 2020 ... ... Janssen R&D subsidiary based in Princeton, NJ, have entered into license agreements with ... discovery and development. Both Roche and J&J have annual Research and Development ...
(Date:8/5/2020)... (PRWEB) , ... August 05, 2020 , ... Regenative Labs ... two new innovations, CoreText™ and ProText™, making them the first Wharton’s jelly allografts to ... using a syringe. The company’s solutions are the first Wharton’s jelly allograft product to ...
(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life ... and compliance, announces a new solution to manage regulated workloads on Microsoft Azure. ... their technology stack complies with FDA and global regulations. USDM's new managed service ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... Ariz. (PRWEB) , ... August 13, 2020 , ... ... on its annual Inc. 5000 list, the most prestigious ranking of the nation’s ... companies within the American economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... (EMMA International), a global leader in FDA compliance consulting has been named on ... private companies. The list represents a unique look at the most successful companies ...
(Date:8/3/2020)... LEXINGTON, Ky. (PRWEB) , ... August 03, 2020 , ... ... innovative products for transformative growth, , Known as MediVet Biologics ... Health brand. , The new Ardent Animal Health will build on its ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: