HOME >> BIOLOGY >> NEWS
New drugs for bad bugs

GAINESVILLE, Fla. -- Call it a chemical crystal ball. A new approach to predict whether a drug in development is likely to work and which dose is best could get antibiotics to market faster and more cheaply, say University of Florida researchers.

In recent years, scientists worldwide have sounded the alarm: There simply aren't enough drugs to combat bad bugs. Bacteria are increasingly adept at outwitting the traditional antibiotic arsenal.

Yet designing and testing new antibiotics can be a maddeningly slow and costly process -- if pharmaceutical companies even bother, says Hartmut Derendorf, chairman of the department of pharmaceutics at the University of Florida College of Pharmacy. Many would rather invest in compounds aimed at patients with chronic conditions such as high cholesterol or diabetes, not in drugs designed to be used for a week or two and then stopped once an infection clears, he said.

Now UF researchers have devised a patent-pending method that combines testing of various drug concentrations at the site of infection with a series of laboratory analyses and mathematical models designed to streamline drug development.

The method helps better determine which drugs are worth studying in people and at which dose, avoiding the typically lengthy and expensive trial-and-error approach that can take years.

"About one new antibiotic a year is approved," said Derendorf, who will discuss the technique Saturday (March 5) at the annual meeting of the American Society for Clinical Pharmacology and Therapeutics in Orlando. "That's certainly not enough. Even more worrisome, there are very few in the pipeline right now. Meanwhile, the requirements are getting longer and longer, and this is a huge dilemma with the recent discussion about Vioxx. That's created some doubt in the approval procedure. I think we have to come to a reasonable expectation here in terms of the balance between benefits and potential harm. The worries I
'"/>

Contact: Melanie Ross
ufcardiac@aol.com
352-392-2624
University of Florida
4-Mar-2005


Page: 1 2 3 4

Related biology news :

1. MIT model could predict cells response to drugs
2. New target for HIV/AIDS drugs and vaccine discovered
3. Modified mushrooms may yield human drugs
4. UGR researchers design an alternative to blood test to detect drugs in the body
5. Could fungal collection hold the key to new life-saving drugs?
6. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
7. Scientists develop new drugs to fight colon and breast cancer more effectively
8. Anti-inflammatory drugs interact with HRT, and more
9. Generic biologic drugs unlikely to offer significant savings
10. Stem cells provide new tool for studying disease and identifying ALS drugs
11. Enhancing chemotherapys efficacy: New agent has synergistic effect with standard drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/7/2020)... ... January 06, 2020 , ... Myant Inc. , the pioneers ... Vegas) to bring to life its vision of a world where textile-based interfaces knitted ... the AI-powered digital sphere, and the physical IoT-enabled environment. The experience at Myant’s booth ...
(Date:12/30/2019)... SAN DIEGO (PRWEB) , ... December 30, 2019 , ... ... cooking events company has seen its highest sales in 2019, having hosted a multitude ... and Illumina, have all visited the company’s La Jolla-based venue, and the company has ...
(Date:12/18/2019)... ... December 17, 2019 , ... EconoFact, a non-profit media initiative ... Fletcher School, Tufts University, is pleased to announce a collaboration with Macmillan Learning ... using Macmillan Learning’s acclaimed series of economics textbooks. , Under the agreement, Macmillan ...
Breaking Biology News(10 mins):
(Date:1/8/2020)... ... 08, 2020 , ... Anomet Products has introduced ... use in harsh environments inside or outside of the human body. , ... alloys to achieve specific properties such as corrosion-resistance, biocompatibility, or operation at temperatures ...
(Date:1/7/2020)... ... 07, 2020 , ... Vuja De Sciences (“Vuja De”), a biotechnology startup dedicated ... appointments of Chand Khanna, DVM, PhD, DACVIM (Onc), and Dr. Lee Helman, MD, to ... are delighted to welcome Chand and Lee as new directors. They will be of ...
(Date:1/7/2020)... ... January 06, 2020 , ... ABCT ... emerging biosciences ventures invited to participate in the annual program. Twelve ventures will ... plans and a professional network. All startups will receive an entrepreneur coach, access ...
(Date:12/30/2019)... ... December 30, 2019 , ... Leak ... instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries is pleased ... 11 compliant software program specific to the custom-built helium leak testing systems it ...
Breaking Biology Technology:
Cached News: