HOME >> BIOLOGY >> NEWS
New drugs for bad bugs

GAINESVILLE, Fla. -- Call it a chemical crystal ball. A new approach to predict whether a drug in development is likely to work and which dose is best could get antibiotics to market faster and more cheaply, say University of Florida researchers.

In recent years, scientists worldwide have sounded the alarm: There simply aren't enough drugs to combat bad bugs. Bacteria are increasingly adept at outwitting the traditional antibiotic arsenal.

Yet designing and testing new antibiotics can be a maddeningly slow and costly process -- if pharmaceutical companies even bother, says Hartmut Derendorf, chairman of the department of pharmaceutics at the University of Florida College of Pharmacy. Many would rather invest in compounds aimed at patients with chronic conditions such as high cholesterol or diabetes, not in drugs designed to be used for a week or two and then stopped once an infection clears, he said.

Now UF researchers have devised a patent-pending method that combines testing of various drug concentrations at the site of infection with a series of laboratory analyses and mathematical models designed to streamline drug development.

The method helps better determine which drugs are worth studying in people and at which dose, avoiding the typically lengthy and expensive trial-and-error approach that can take years.

"About one new antibiotic a year is approved," said Derendorf, who will discuss the technique Saturday (March 5) at the annual meeting of the American Society for Clinical Pharmacology and Therapeutics in Orlando. "That's certainly not enough. Even more worrisome, there are very few in the pipeline right now. Meanwhile, the requirements are getting longer and longer, and this is a huge dilemma with the recent discussion about Vioxx. That's created some doubt in the approval procedure. I think we have to come to a reasonable expectation here in terms of the balance between benefits and potential harm. The worries I
'"/>

Contact: Melanie Ross
ufcardiac@aol.com
352-392-2624
University of Florida
4-Mar-2005


Page: 1 2 3 4

Related biology news :

1. MIT model could predict cells response to drugs
2. New target for HIV/AIDS drugs and vaccine discovered
3. Modified mushrooms may yield human drugs
4. UGR researchers design an alternative to blood test to detect drugs in the body
5. Could fungal collection hold the key to new life-saving drugs?
6. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
7. Scientists develop new drugs to fight colon and breast cancer more effectively
8. Anti-inflammatory drugs interact with HRT, and more
9. Generic biologic drugs unlikely to offer significant savings
10. Stem cells provide new tool for studying disease and identifying ALS drugs
11. Enhancing chemotherapys efficacy: New agent has synergistic effect with standard drugs

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New drugs for bad bugs

(Date:10/31/2014)... live in Nuristan Province – some 60 years after ... glands are more valuable than gold , Study appears ... , NEW YORK (October 31, 2014) – More ... strange deer with vampire-like fangs still persists in the ... research team led by the Wildlife Conservation Society (WCS), ...
(Date:10/31/2014)... wide part of the electromagnetic spectrum from the infrared ... Sweden. The MAX IV facility presents a range of ... parts in a storage - ring synchrotron system that ... metres. Nevertheless, if these various challenges can be addressed ... source brightness and transverse coherence will be possible. ...
(Date:10/31/2014)... air out of a nagging mystery about the development of ... to why animal species didn,t flourish sooner, once sufficient oxygen ... end of the Proterozoic period, about 800 million years ago ... most researchers think there also was plenty of oxygen? , ... all. , In a study published Oct. 30 in ...
Breaking Biology News(10 mins):Strange, fanged deer persists in Afghanistan 2A new generation of storage -- ring 2Lack of oxygen delayed the rise of animals on Earth 2
(Date:10/31/2014)... 2014 Having access to safe drinking ... battle in many corners of the globe. It’s a ... in northwestern Bolivia where many have been sickened by ... Fairfield University’s School of Engineering has been working to ... (UAC), “the united college for the peasants.” A branch ...
(Date:10/31/2014)... 2014 Caustic soda is utilized in the ... At present, China takes lead in the global caustic soda ... a number of facilities in the USA, Germany, Brazil and ... soda market in terms of output and production capacities. , ... average by 3% per year in the years ahead. The ...
(Date:10/31/2014)... IL (PRWEB) October 30, 2014 ... Insight Product Development’s decades-long heritage in successful medical ... world context for what it takes to successfully ... space. As part of a two-hour on-site class, ... Kellogg school of business, McCormick School of Engineering, ...
(Date:10/31/2014)... MA (PRWEB) October 30, 2014 ... Latin America were hosted by Charm Sciences at ... During their week in the US, the participants ... residue control, hygiene management, and process verification, and ... facility. , This was the first visit to ...
Breaking Biology Technology:Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3China to Dominate Caustic Soda Market Through 2018, Says Merchant Research & Consulting in Its New Study 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 3Charm Sciences Hosts Executives from Latin America for Dairy Safety Executive Seminar 2
Cached News: